Pros1 protein S [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Pros1provided by RGD
Official Full Name: protein Sprovided by RGD
Primary source: RGD:620971
See related: EnsemblRapid:ENSRNOG00000048723 AllianceGenome:RGD:620971
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Pros
Summary: Predicted to enable calcium ion binding activity. Involved in several processes, including liver development; positive regulation of phagocytosis; and response to lipopolysaccharide. Located in extracellular space. Part of protein-containing complex. Human ortholog(s) of this gene implicated in autosomal dominant thrombophilia due to protein S deficiency; autosomal recessive thrombophilia due to protein S deficiency; cerebral infarction; and protein S deficiency. Orthologous to human PROS1 (protein S). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Liver (RPKM 702.8), Lung (RPKM 198.1) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 11p12

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	11	NC_086029.1 (13676310..13757858)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	11	NC_051346.1 (230597..311288)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (1206648..1288140)

Chromosome 11 - NC_086029.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

vitamin K-dependent factor, protein S, regulates brain neural stem cell migration and phagocytic activities towards glioma cells
Title: The vitamin K-dependent factor, protein S, regulates brain neural stem cell migration and phagocytic activities towards glioma cells.
Our results support a protective role of PS against glomerular injury in DN progression.
Title: Protein S Protects against Podocyte Injury in Diabetic Nephropathy.
LPS-induced decreased PS expression in hepatocytes and SECs is mediated by MEK/ERK signaling and NFkappaB activation and membrane-bound CD14 and TLR-4 are involved in this mechanism
Title: Lipopolysaccharide-induced decreased protein S expression in liver cells is mediated by MEK/ERK signaling and NFkappaB activation: involvement of membrane-bound CD14 and toll-like receptor-4.

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General gene information

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Markers

RH140134 (e-PCR)
- UniSTS:222213

RH141031 (e-PCR)
- UniSTS:223031

AU048234 (e-PCR)
- UniSTS:109738

RH128863 (e-PCR)
- UniSTS:212171

AU026057 (e-PCR)
- UniSTS:114655

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables protein-containing complex binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in blood coagulation	IEA Inferred from Electronic Annotation more info
involved_in fibrinolysis	IEA Inferred from Electronic Annotation more info
involved_in liver development	IEP Inferred from Expression Pattern more info	PubMed
involved_in negative regulation of coagulation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of phagocytosis	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in response to axon injury	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to lipopolysaccharide	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	IEA Inferred from Electronic Annotation more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: vitamin K-dependent protein S

Names: protein S (alpha)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031086.2 → NP_112348.2 vitamin K-dependent protein S precursor

See identical proteins and their annotated locations for NP_112348.2

Status: VALIDATED

Source sequence(s)

BC091117, CB580854, CB790907, CK366505, CV105055, DV727991, DY571157

UniProtKB/Swiss-Prot

P53813

UniProtKB/TrEMBL

A6KT01, M0R5R0

Related

ENSRNOP00000112145.1, ENSRNOT00000151051.1

Conserved Domains (6) summary

smart00069
Location:23 → 85

GLA; Domain containing Gla (gamma-carboxyglutamate) residues

cd00054
Location:119 → 155

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

pfam00054
Location:329 → 459

Laminin_G_1; Laminin G domain

pfam07645
Location:201 → 241

EGF_CA; Calcium-binding EGF domain

pfam14670
Location:168 → 199

FXa_inhibition; Coagulation Factor Xa inhibitory site

cl22861
Location:514 → 646

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086029.1 Reference GRCr8

Range

13676310..13757858

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039088635.2 → XP_038944563.1 vitamin K-dependent protein S isoform X1

UniProtKB/TrEMBL

A0A8I6APZ0

Related

ENSRNOP00000091181.1, ENSRNOT00000096661.2

Conserved Domains (6) summary

smart00179
Location:121 → 153

EGF_CA; Calcium-binding EGF-like domain

cd00054
Location:39 → 75

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

pfam00054
Location:249 → 379

Laminin_G_1; Laminin G domain

pfam12662
Location:144 → 166

cEGF; Complement Clr-like EGF-like

pfam14670
Location:88 → 119

FXa_inhibition; Coagulation Factor Xa inhibitory site

cl22861
Location:429 → 566

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
XM_039088636.2 → XP_038944564.1 vitamin K-dependent protein S isoform X2

Conserved Domains (3) summary

pfam00054
Location:95 → 225

Laminin_G_1; Laminin G domain

pfam14670
Location:13 → 48

FXa_inhibition; Coagulation Factor Xa inhibitory site

cl22861
Location:248 → 410

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...