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    Tyw3 tRNA-yW synthesizing protein 3 homolog [ Rattus norvegicus (Norway rat) ]

    Gene ID: 499731, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tyw3provided by RGD
    Official Full Name
    tRNA-yW synthesizing protein 3 homologprovided by RGD
    Primary source
    RGD:1559623
    See related
    EnsemblRapid:ENSRNOG00000028328 AllianceGenome:RGD:1559623
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1559623
    Summary
    Predicted to enable tRNA methyltransferase activity. Predicted to be involved in tRNA methylation and wybutosine biosynthetic process. Predicted to be active in cytoplasm. Orthologous to human TYW3 (tRNA-yW synthesizing protein 3 homolog). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 61.7), Heart (RPKM 39.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tyw3 in Genome Data Viewer
    Location:
    2q45
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (246189627..246211737, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (243529912..243552043, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (260861825..260884270, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein L13, pseudogene 20 Neighboring gene voltage-dependent anion channel 1, pseudogene 14 Neighboring gene 40S ribosomal protein S7 pseudogene Neighboring gene crystallin zeta Neighboring gene uncharacterized LOC120100979

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables tRNA methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in tRNA methylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in wybutosine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    tRNA wybutosine-synthesizing protein 3 homolog
    NP_001386344.1
    NP_001386345.1
    XP_038959818.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001399415.1 → NP_001386344.1  tRNA wybutosine-synthesizing protein 3 homolog isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/TrEMBL
      A6HWQ0, A6HWQ1
      Related
      ENSRNOP00000037831.5, ENSRNOT00000032874.8
      Conserved Domains (1) summary
      pfam02676
      Location:10 → 193
      TYW3; Methyltransferase TYW3

    2. NM_001399416.1 → NP_001386345.1  tRNA wybutosine-synthesizing protein 3 homolog isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/TrEMBL
      A0A8I5ZSZ8, A6HWQ2
      Related
      ENSRNOP00000082080.1, ENSRNOT00000105899.2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      246189627..246211737 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039103890.2 → XP_038959818.1  tRNA wybutosine-synthesizing protein 3 homolog isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZL47, D3ZHR8
      Related
      ENSRNOP00000078566.1, ENSRNOT00000096868.2
      Conserved Domains (1) summary
      pfam02676
      Location:45 → 204
      TYW3; Methyltransferase TYW3
    Nucleotide Protein Strain
    Heading Accession and Version

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