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    ROBO2 roundabout guidance receptor 2 [ Homo sapiens (human) ]

    Gene ID: 6092, updated on 4-Jan-2025

    Summary

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    Official Symbol
    ROBO2provided by HGNC
    Official Full Name
    roundabout guidance receptor 2provided by HGNC
    Primary source
    HGNC:HGNC:10250
    See related
    Ensembl:ENSG00000185008 MIM:602431; AllianceGenome:HGNC:10250
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SAX3
    Summary
    The protein encoded by this gene belongs to the ROBO family, part of the immunoglobulin superfamily of proteins that are highly conserved from fly to human. The encoded protein is a transmembrane receptor for the slit homolog 2 protein and functions in axon guidance and cell migration. Mutations in this gene are associated with vesicoureteral reflux, characterized by the backward flow of urine from the bladder into the ureters or the kidney. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]
    Expression
    Broad expression in brain (RPKM 5.1), lung (RPKM 2.8) and 14 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ROBO2 in Genome Data Viewer
    Location:
    3p12.3
    Exon count:
    34
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (75906675..77649964)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (75959914..77704808)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (75955826..77699115)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:75821208-75821708 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:75821709-75822209 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20105 Neighboring gene MPRA-validated peak4708 silencer Neighboring gene RNA, 7SL, cytoplasmic 92, pseudogene Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr3:75899387-75899888 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr3:75899889-75900388 Neighboring gene zinc finger protein 717 Neighboring gene microRNA 4273 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:75955554-75956084 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:75956085-75956613 Neighboring gene NANOG hESC enhancer GRCh37_chr3:75982289-75982809 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr3:76008545-76009744 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:76092499-76093032 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr3:76093033-76093565 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr3:76119119-76119976 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr3:76247194-76247810 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr3:76251853-76253052 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_71192 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr3:76291943-76292450 Neighboring gene uncharacterized LOC124900544 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr3:76518793-76519992 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr3:76546619-76547252 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_71246 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_71286 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20106 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:76600516-76601016 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:76601017-76601517 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_71345 Neighboring gene CAP1 pseudogene 1 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_71357 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_71361 Neighboring gene MPRA-validated peak4710 silencer Neighboring gene uncharacterized LOC102724949 Neighboring gene MPRA-validated peak4713 silencer Neighboring gene MPRA-validated peak4717 silencer Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr3:77039649-77040150 Neighboring gene MPRA-validated peak4720 silencer Neighboring gene MPRA-validated peak4719 silencer Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr3:77214086-77214814 Neighboring gene RNA, U6 small nuclear 386, pseudogene Neighboring gene MPRA-validated peak4724 silencer Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr3:77359951-77361150 Neighboring gene voltage dependent anion channel 1 pseudogene 7 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr3:77524547-77525070 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr3:77582237-77583436 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr3:77623115-77624314 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr3:77735685-77736226 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr3:77844088-77844666 Neighboring gene uncharacterized LOC105377171 Neighboring gene RNA, U6 small nuclear 217, pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. In search of genes associated with risk for psychopathic tendencies in children: a two-stage genome-wide association study of pooled DNA. Viding E, et al. J Child Psychol Psychiatry, 2010 Jul. PMID 20345837
    2. Heterozygous non-synonymous ROBO2 variants are unlikely to be sufficient to cause familial vesicoureteric reflux. Dobson MG, et al. Kidney Int, 2013 Aug. PMID 23536131
    3. ROBO2 gene variants are associated with familial vesicoureteral reflux. Bertoli-Avella AM, et al. J Am Soc Nephrol, 2008 Apr. PMID 18235093, Free PMC Article
    4. Replication of a ROBO2 polymorphism associated with conduct problems but not psychopathic tendencies in children. Dadds MR, et al. Psychiatr Genet, 2013 Dec. PMID 23982283
    5. Down-regulation of ROBO2 expression in prostate cancers. Choi YJ, et al. Pathol Oncol Res, 2014 Jul. PMID 24272677, Free PMC Article

    See all (67) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Overexpression of miR-25 Downregulates the Expression of ROBO2 in Idiopathic Intellectual Disability.
      Title: Overexpression of miR-25 Downregulates the Expression of ROBO2 in Idiopathic Intellectual Disability.
    2. SALL4 advances the proliferation and tumor cell stemness of colon cancer cells through the transcription and regulation of ROBO2.
      Title: SALL4 advances the proliferation and tumor cell stemness of colon cancer cells through the transcription and regulation of ROBO2.
    3. Conformational Change of the Hairpin-like-structured Robo2 Ectodomain Allows NELL1/2 Binding.
      Title: Conformational Change of the Hairpin-like-structured Robo2 Ectodomain Allows NELL1/2 Binding.
    4. An ancient founder mutation located between ROBO1 and ROBO2 is responsible for increased microtia risk in Amerindigenous populations.
      Title: An ancient founder mutation located between ROBO1 and ROBO2 is responsible for increased microtia risk in Amerindigenous populations.
    5. ROBO2 hampers malignant biological behavior and predicts a better prognosis in pancreatic adenocarcinoma.
      Title: ROBO2 hampers malignant biological behavior and predicts a better prognosis in pancreatic adenocarcinoma.
    6. Investigation of DNA variants specific to ROBO2 Isoform 'a' in Irish vesicoureteric reflux patients reveals marked CpG island variation.
      Title: Investigation of DNA variants specific to ROBO2 Isoform 'a' in Irish vesicoureteric reflux patients reveals marked CpG island variation.
    7. The gene ROBO2 was decreased in patients with COPD and this decrease was significantly negatively correlated with the disease stages of COPD
      Title: Roundabout signaling pathway involved in the pathogenesis of COPD by integrative bioinformatics analysis.
    8. results suggest that Robo2 functions as a receptor for NELL1/2, particularly under circumstances where Robo2 undergoes proteolytic digestion
      Title: Robo2 contains a cryptic binding site for neural EGFL-like (NELL) protein 1/2.
    9. determined the crystal structure of the tandem Ig4-5 domains (D4-5) of human Robo2 and found that a hydrophobic surface on D4 mediates close homotypic contacts with a reciprocal D4
      Title: Robo Ig4 Is a Dimerization Domain.
    10. human placental multipotent mesenchymal stromal cell express Slit2 and both Robo1 and Robo4 are present in human umbilical vein endothelial cells.
      Title: Human placental multipotent mesenchymal stromal cells modulate placenta angiogenesis through Slit2-Robo signaling.
    Submit: New GeneRIF Correction See all GeneRIFs (29)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Associated conditions

    Description Tests
    Vesicoureteral reflux 2
    MedGen: C1970483 OMIM: 610878 GeneReviews: Not available
    		Compare labs

    EBI GWAS Catalog

    Description
    A genome-wide association study of schizophrenia using brain activation as a quantitative phenotype.
    EBI GWAS Catalog
    Common variation near ROBO2 is associated with expressive vocabulary in infancy.
    EBI GWAS Catalog
    Genetic variants associated with disordered eating.
    EBI GWAS Catalog
    Genome-wide association study of chronic periodontitis in a general German population.
    EBI GWAS Catalog
    Genome-wide association study of circulating estradiol, testosterone, and sex hormone-binding globulin in postmenopausal women.
    EBI GWAS Catalog
    Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid.
    EBI GWAS Catalog
    Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA1568

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables axon guidance receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables axon guidance receptor activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables identical protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in aorta development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in aortic valve morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in apoptotic process involved in luteolysis IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in axon guidance ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in axon midline choice point recognition ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in brain development IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in cell-cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellular response to hormone stimulus IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in central nervous system development NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in chemotaxis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in endocardial cushion formation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in heart induction ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in homophilic cell adhesion via plasma membrane adhesion molecules IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in metanephros development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of negative chemotaxis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of synapse assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in olfactory bulb interneuron development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in outflow tract septum morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of Notch signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of axonogenesis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in pulmonary valve morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in retinal ganglion cell axon guidance ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in ureteric bud development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ventricular septum morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in axolemma ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular exosome HDA PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    roundabout homolog 2
    Names
    roundabout, axon guidance receptor, homolog 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_027734.2 RefSeqGene

      Range
      1138406..1748271
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001128929.3 → NP_001122401.1  roundabout homolog 2 isoform ROBO2a precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the use of an alternate promoter and has multiple differences compared to variant 4. These differences result in a distinct 5' UTR and the use of an alternate start codon compared to variant 4. The encoded protein (isoform ROBO2a; PMID 16829019) has a distinct N-terminus and is shorter than isoform 4.
      Source sequence(s)
      AC126467, AC133040, DQ533873
      Consensus CDS
      CCDS54609.1
      UniProtKB/Swiss-Prot
      Q9HCK4
      Related
      ENSP00000417335.2, ENST00000487694.7
      Conserved Domains (7) summary
      cd00096
      Location:451 → 518
      Ig; Immunoglobulin domain
      cd05726
      Location:344 → 433
      Ig4_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
      cd07693
      Location:46 → 145
      Ig1_Robo; First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins
      smart00410
      Location:440 → 521
      IG_like; Immunoglobulin like
      cd00063
      Location:538 → 631
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:241 → 326
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:153 → 237
      Ig; Immunoglobulin domain

    2. NM_001290039.2 → NP_001276968.1  roundabout homolog 2 isoform 3 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 3' coding region compared to variant 4. The encoded protein (isoform 3) is shorter than variant 4.
      Source sequence(s)
      AC117515, AC117516, AC133040, BC144306, DQ533874
      UniProtKB/Swiss-Prot
      Q9HCK4
      Conserved Domains (7) summary
      cd00096
      Location:439 → 506
      Ig; Immunoglobulin domain
      cd05726
      Location:332 → 421
      Ig4_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
      cd07693
      Location:30 → 129
      Ig1_Robo; First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins
      smart00410
      Location:428 → 509
      IG_like; Immunoglobulin like
      cd00063
      Location:526 → 619
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:225 → 310
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:137 → 221
      Ig; Immunoglobulin domain

    3. NM_001290040.2 → NP_001276969.1  roundabout homolog 2 isoform 4 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) represents the longest transcript and encodes the longest isoform (4).
      Source sequence(s)
      AC117515, AC133040, BC144303, DQ533874
      Consensus CDS
      CCDS93318.1
      UniProtKB/TrEMBL
      F8W703
      Related
      ENSP00000327536.9, ENST00000332191.13
      Conserved Domains (7) summary
      cd00096
      Location:439 → 506
      Ig; Immunoglobulin domain
      cd05726
      Location:332 → 421
      Ig4_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
      cd07693
      Location:30 → 129
      Ig1_Robo; First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins
      smart00410
      Location:428 → 509
      IG_like; Immunoglobulin like
      cd00063
      Location:526 → 619
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:225 → 310
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:137 → 221
      Ig; Immunoglobulin domain

    4. NM_001290065.2 → NP_001276994.1  roundabout homolog 2 isoform 5

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) has multiple differences compared to variant 4. These differences result in a distinct 5' UTR and cause translation initiation at a downstream start codon compared to variant 4; the 5'-most initiation codon, as used in variant 4, is associated with a truncated ORF that would render the transcript a candidate for nonsense-mediated decay (NMD). Leaky scanning may allow translation initiation at the downstream AUG resulting in an isoform (5) with a shorter N-terminus compared to isoform 4.
      Source sequence(s)
      AC117515, AC133040, BC144302, DQ533874
      UniProtKB/Swiss-Prot
      Q9HCK4
      Conserved Domains (1) summary
      cd00063
      Location:147 → 239
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

    5. NM_001378190.1 → NP_001365119.1  roundabout homolog 2 isoform 6 precursor

      Status: REVIEWED

      Source sequence(s)
      AC117515, AC117516, AC126467, AC133040
      Conserved Domains (6) summary
      cd00063
      Location:542 → 635
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00096
      Location:152 → 155
      Ig; Ig strand A [structural motif]
      cd05726
      Location:335 → 432
      IgI_4_Robo; Fourth immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of Ig superfamily (IgSF) domains
      cd07693
      Location:47 → 145
      IgC_1_Robo; First immunoglobulin (Ig)-like constant domain in Robo (roundabout) receptors, and similar domains
      cd20952
      Location:439 → 525
      IgI_5_Robo; Fifth Ig-like domain of Roundabout (Robo) homolog 1/2, and similar domains; a member of the I-set of IgSF domains
      cl11960
      Location:152 → 237
      Ig; Immunoglobulin domain

    6. NM_001378191.1 → NP_001365120.1  roundabout homolog 2 isoform 7 precursor

      Status: REVIEWED

      Source sequence(s)
      AC117515, AC117516, AC126467, AC133040
      Consensus CDS
      CCDS93314.1
      UniProtKB/TrEMBL
      A0A8Q3SIW8
      Related
      ENSP00000512767.1, ENST00000696630.1
      Conserved Domains (6) summary
      cd00063
      Location:542 → 635
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00096
      Location:152 → 155
      Ig; Ig strand A [structural motif]
      cd05726
      Location:335 → 432
      IgI_4_Robo; Fourth immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of Ig superfamily (IgSF) domains
      cd07693
      Location:47 → 145
      IgC_1_Robo; First immunoglobulin (Ig)-like constant domain in Robo (roundabout) receptors, and similar domains
      cd20952
      Location:439 → 525
      IgI_5_Robo; Fifth Ig-like domain of Roundabout (Robo) homolog 1/2, and similar domains; a member of the I-set of IgSF domains
      cl11960
      Location:152 → 237
      Ig; Immunoglobulin domain

    7. NM_001378192.1 → NP_001365121.1  roundabout homolog 2 isoform 8 precursor

      Status: REVIEWED

      Source sequence(s)
      AC067717, AC117515, AC117516, AC133040
      Conserved Domains (6) summary
      cd00063
      Location:549 → 642
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00096
      Location:159 → 162
      Ig; Ig strand A [structural motif]
      cd05726
      Location:342 → 439
      IgI_4_Robo; Fourth immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of Ig superfamily (IgSF) domains
      cd07693
      Location:54 → 152
      IgC_1_Robo; First immunoglobulin (Ig)-like constant domain in Robo (roundabout) receptors, and similar domains
      cd20952
      Location:446 → 532
      IgI_5_Robo; Fifth Ig-like domain of Roundabout (Robo) homolog 1/2, and similar domains; a member of the I-set of IgSF domains
      cl11960
      Location:159 → 244
      Ig; Immunoglobulin domain

    8. NM_001378193.1 → NP_001365122.1  roundabout homolog 2 isoform 9 precursor

      Status: REVIEWED

      Source sequence(s)
      AC117515, AC117516, AC133040
      Consensus CDS
      CCDS93321.1
      UniProtKB/TrEMBL
      H7C4J7
      Related
      ENSP00000417471.2, ENST00000490534.2
      Conserved Domains (6) summary
      cd00063
      Location:522 → 615
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00096
      Location:136 → 139
      Ig; Ig strand A [structural motif]
      cd05726
      Location:315 → 412
      IgI_4_Robo; Fourth immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of Ig superfamily (IgSF) domains
      cd07693
      Location:31 → 129
      IgC_1_Robo; First immunoglobulin (Ig)-like constant domain in Robo (roundabout) receptors, and similar domains
      cd20952
      Location:419 → 505
      IgI_5_Robo; Fifth Ig-like domain of Roundabout (Robo) homolog 1/2, and similar domains; a member of the I-set of IgSF domains
      cl11960
      Location:136 → 221
      Ig; Immunoglobulin domain

    9. NM_001378194.1 → NP_001365123.1  roundabout homolog 2 isoform 10 precursor

      Status: REVIEWED

      Source sequence(s)
      AC067717, AC117515, AC117516, AC133040
      Conserved Domains (6) summary
      cd00063
      Location:549 → 642
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00096
      Location:159 → 162
      Ig; Ig strand A [structural motif]
      cd05726
      Location:342 → 439
      IgI_4_Robo; Fourth immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of Ig superfamily (IgSF) domains
      cd07693
      Location:54 → 152
      IgC_1_Robo; First immunoglobulin (Ig)-like constant domain in Robo (roundabout) receptors, and similar domains
      cd20952
      Location:446 → 532
      IgI_5_Robo; Fifth Ig-like domain of Roundabout (Robo) homolog 1/2, and similar domains; a member of the I-set of IgSF domains
      cl11960
      Location:159 → 244
      Ig; Immunoglobulin domain

    10. NM_001378195.1 → NP_001365124.1  roundabout homolog 2 isoform 11 precursor

      Status: REVIEWED

      Source sequence(s)
      AC117515, AC117516, AC126467, AC133040
      Consensus CDS
      CCDS93316.1
      UniProtKB/TrEMBL
      A0A8Q3SIU0
      Related
      ENSP00000512766.1, ENST00000696629.1
      Conserved Domains (6) summary
      cd00063
      Location:542 → 635
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00096
      Location:152 → 155
      Ig; Ig strand A [structural motif]
      cd05726
      Location:335 → 432
      IgI_4_Robo; Fourth immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of Ig superfamily (IgSF) domains
      cd07693
      Location:47 → 145
      IgC_1_Robo; First immunoglobulin (Ig)-like constant domain in Robo (roundabout) receptors, and similar domains
      cd20952
      Location:439 → 525
      IgI_5_Robo; Fifth Ig-like domain of Roundabout (Robo) homolog 1/2, and similar domains; a member of the I-set of IgSF domains
      cl11960
      Location:152 → 237
      Ig; Immunoglobulin domain

    11. NM_001378196.1 → NP_001365125.1  roundabout homolog 2 isoform 12 precursor

      Status: REVIEWED

      Source sequence(s)
      AC117515, AC117516, AC126467, AC133040
      Consensus CDS
      CCDS93315.1
      UniProtKB/TrEMBL
      H7C4U9
      Related
      ENSP00000418190.2, ENST00000471893.2
      Conserved Domains (6) summary
      cd00063
      Location:542 → 635
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00096
      Location:152 → 155
      Ig; Ig strand A [structural motif]
      cd05726
      Location:335 → 432
      IgI_4_Robo; Fourth immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of Ig superfamily (IgSF) domains
      cd07693
      Location:47 → 145
      IgC_1_Robo; First immunoglobulin (Ig)-like constant domain in Robo (roundabout) receptors, and similar domains
      cd20952
      Location:439 → 525
      IgI_5_Robo; Fifth Ig-like domain of Roundabout (Robo) homolog 1/2, and similar domains; a member of the I-set of IgSF domains
      cl11960
      Location:152 → 237
      Ig; Immunoglobulin domain

    12. NM_001378197.1 → NP_001365126.1  roundabout homolog 2 isoform 13 precursor

      Status: REVIEWED

      Source sequence(s)
      AC117515, AC117516, AC133040
      Consensus CDS
      CCDS93320.1
      UniProtKB/TrEMBL
      A0A994J7I9
      Related
      ENSP00000516193.1, ENST00000705983.1
      Conserved Domains (6) summary
      cd00063
      Location:522 → 615
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00096
      Location:136 → 139
      Ig; Ig strand A [structural motif]
      cd05726
      Location:315 → 412
      IgI_4_Robo; Fourth immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of Ig superfamily (IgSF) domains
      cd07693
      Location:31 → 129
      IgC_1_Robo; First immunoglobulin (Ig)-like constant domain in Robo (roundabout) receptors, and similar domains
      cd20952
      Location:419 → 505
      IgI_5_Robo; Fifth Ig-like domain of Roundabout (Robo) homolog 1/2, and similar domains; a member of the I-set of IgSF domains
      cl11960
      Location:136 → 221
      Ig; Immunoglobulin domain

    13. NM_001378198.1 → NP_001365127.1  roundabout homolog 2 isoform 14 precursor

      Status: REVIEWED

      Source sequence(s)
      AC067717, AC117515, AC117516, AC133040
      Conserved Domains (6) summary
      cd00063
      Location:549 → 642
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00096
      Location:159 → 162
      Ig; Ig strand A [structural motif]
      cd05726
      Location:342 → 439
      IgI_4_Robo; Fourth immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of Ig superfamily (IgSF) domains
      cd07693
      Location:54 → 152
      IgC_1_Robo; First immunoglobulin (Ig)-like constant domain in Robo (roundabout) receptors, and similar domains
      cd20952
      Location:446 → 532
      IgI_5_Robo; Fifth Ig-like domain of Roundabout (Robo) homolog 1/2, and similar domains; a member of the I-set of IgSF domains
      cl11960
      Location:159 → 244
      Ig; Immunoglobulin domain

    14. NM_001378199.1 → NP_001365128.1  roundabout homolog 2 isoform 15 precursor

      Status: REVIEWED

      Source sequence(s)
      AC067717, AC117515, AC117516, AC133040
      Consensus CDS
      CCDS93317.1
      UniProtKB/TrEMBL
      H7C4W9
      Related
      ENSP00000418446.2, ENST00000475334.2
      Conserved Domains (6) summary
      cd00063
      Location:549 → 642
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00096
      Location:159 → 162
      Ig; Ig strand A [structural motif]
      cd05726
      Location:342 → 439
      IgI_4_Robo; Fourth immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of Ig superfamily (IgSF) domains
      cd07693
      Location:54 → 152
      IgC_1_Robo; First immunoglobulin (Ig)-like constant domain in Robo (roundabout) receptors, and similar domains
      cd20952
      Location:446 → 532
      IgI_5_Robo; Fifth Ig-like domain of Roundabout (Robo) homolog 1/2, and similar domains; a member of the I-set of IgSF domains
      cl11960
      Location:159 → 244
      Ig; Immunoglobulin domain

    15. NM_001378200.1 → NP_001365129.1  roundabout homolog 2 isoform 16 precursor

      Status: REVIEWED

      Source sequence(s)
      AC117515, AC117516, AC126467, AC133040
      Conserved Domains (6) summary
      cd00063
      Location:542 → 635
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00096
      Location:152 → 155
      Ig; Ig strand A [structural motif]
      cd05726
      Location:335 → 432
      IgI_4_Robo; Fourth immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of Ig superfamily (IgSF) domains
      cd07693
      Location:47 → 145
      IgC_1_Robo; First immunoglobulin (Ig)-like constant domain in Robo (roundabout) receptors, and similar domains
      cd20952
      Location:439 → 525
      IgI_5_Robo; Fifth Ig-like domain of Roundabout (Robo) homolog 1/2, and similar domains; a member of the I-set of IgSF domains
      cl11960
      Location:152 → 237
      Ig; Immunoglobulin domain

    16. NM_001378201.1 → NP_001365130.1  roundabout homolog 2 isoform 17 precursor

      Status: REVIEWED

      Source sequence(s)
      AC117515, AC117516, AC126467, AC133040
      Conserved Domains (6) summary
      cd00063
      Location:542 → 635
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00096
      Location:152 → 155
      Ig; Ig strand A [structural motif]
      cd05726
      Location:335 → 432
      IgI_4_Robo; Fourth immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of Ig superfamily (IgSF) domains
      cd07693
      Location:47 → 145
      IgC_1_Robo; First immunoglobulin (Ig)-like constant domain in Robo (roundabout) receptors, and similar domains
      cd20952
      Location:439 → 525
      IgI_5_Robo; Fifth Ig-like domain of Roundabout (Robo) homolog 1/2, and similar domains; a member of the I-set of IgSF domains
      cl11960
      Location:152 → 237
      Ig; Immunoglobulin domain

    17. NM_001378202.1 → NP_001365131.1  roundabout homolog 2 isoform 18 precursor

      Status: REVIEWED

      Source sequence(s)
      AC117515, AC117516, AC133040
      Conserved Domains (6) summary
      cd00063
      Location:526 → 619
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00096
      Location:136 → 139
      Ig; Ig strand A [structural motif]
      cd05726
      Location:319 → 416
      IgI_4_Robo; Fourth immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of Ig superfamily (IgSF) domains
      cd07693
      Location:31 → 129
      IgC_1_Robo; First immunoglobulin (Ig)-like constant domain in Robo (roundabout) receptors, and similar domains
      cd20952
      Location:423 → 509
      IgI_5_Robo; Fifth Ig-like domain of Roundabout (Robo) homolog 1/2, and similar domains; a member of the I-set of IgSF domains
      cl11960
      Location:136 → 221
      Ig; Immunoglobulin domain

    18. NM_001378203.1 → NP_001365132.1  roundabout homolog 2 isoform 19 precursor

      Status: REVIEWED

      Source sequence(s)
      AC117515, AC117516, AC126467, AC133040
      Conserved Domains (6) summary
      cd00063
      Location:542 → 635
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00096
      Location:152 → 155
      Ig; Ig strand A [structural motif]
      cd05726
      Location:335 → 432
      IgI_4_Robo; Fourth immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of Ig superfamily (IgSF) domains
      cd07693
      Location:47 → 145
      IgC_1_Robo; First immunoglobulin (Ig)-like constant domain in Robo (roundabout) receptors, and similar domains
      cd20952
      Location:439 → 525
      IgI_5_Robo; Fifth Ig-like domain of Roundabout (Robo) homolog 1/2, and similar domains; a member of the I-set of IgSF domains
      cl11960
      Location:152 → 237
      Ig; Immunoglobulin domain

    19. NM_001394212.1 → NP_001381141.1  roundabout homolog 2 isoform 20 precursor

      Status: REVIEWED

      Source sequence(s)
      AC067717, AC117515, AC117516, AC133040
      Conserved Domains (6) summary
      cd00063
      Location:545 → 638
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00096
      Location:159 → 162
      Ig; Ig strand A [structural motif]
      cd05726
      Location:338 → 435
      IgI_4_Robo; Fourth immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of Ig superfamily (IgSF) domains
      cd07693
      Location:54 → 152
      IgC_1_Robo; First immunoglobulin (Ig)-like constant domain in Robo (roundabout) receptors, and similar domains
      cd20952
      Location:442 → 528
      IgI_5_Robo; Fifth Ig-like domain of Roundabout (Robo) homolog 1/2, and similar domains; a member of the I-set of IgSF domains
      cl11960
      Location:159 → 244
      Ig; Immunoglobulin domain

    20. NM_001394213.1 → NP_001381142.1  roundabout homolog 2 isoform 21 precursor

      Status: REVIEWED

      Source sequence(s)
      AC067717, AC117515, AC117516, AC133040
      Conserved Domains (6) summary
      cd00063
      Location:549 → 642
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00096
      Location:159 → 162
      Ig; Ig strand A [structural motif]
      cd05726
      Location:342 → 439
      IgI_4_Robo; Fourth immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of Ig superfamily (IgSF) domains
      cd07693
      Location:54 → 152
      IgC_1_Robo; First immunoglobulin (Ig)-like constant domain in Robo (roundabout) receptors, and similar domains
      cd20952
      Location:446 → 532
      IgI_5_Robo; Fifth Ig-like domain of Roundabout (Robo) homolog 1/2, and similar domains; a member of the I-set of IgSF domains
      cl11960
      Location:159 → 244
      Ig; Immunoglobulin domain

    21. NM_001394214.1 → NP_001381143.1  roundabout homolog 2 isoform 22 precursor

      Status: REVIEWED

      Source sequence(s)
      AC067717, AC117515, AC117516, AC133040
      Conserved Domains (6) summary
      cd00063
      Location:545 → 638
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00096
      Location:159 → 162
      Ig; Ig strand A [structural motif]
      cd05726
      Location:338 → 435
      IgI_4_Robo; Fourth immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of Ig superfamily (IgSF) domains
      cd07693
      Location:54 → 152
      IgC_1_Robo; First immunoglobulin (Ig)-like constant domain in Robo (roundabout) receptors, and similar domains
      cd20952
      Location:442 → 528
      IgI_5_Robo; Fifth Ig-like domain of Roundabout (Robo) homolog 1/2, and similar domains; a member of the I-set of IgSF domains
      cl11960
      Location:159 → 244
      Ig; Immunoglobulin domain

    22. NM_001395656.1 → NP_001382585.1  roundabout homolog 2 isoform 23 precursor

      Status: REVIEWED

      Source sequence(s)
      AC117515, AC117516, AC133040
      Consensus CDS
      CCDS93319.1
      UniProtKB/TrEMBL
      A0A8Q3WLE3
      Related
      ENSP00000512738.1, ENST00000696593.1
      Conserved Domains (6) summary
      cd00063
      Location:526 → 619
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00096
      Location:136 → 139
      Ig; Ig strand A [structural motif]
      cd05726
      Location:319 → 416
      IgI_4_Robo; Fourth immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of Ig superfamily (IgSF) domains
      cd07693
      Location:31 → 129
      IgC_1_Robo; First immunoglobulin (Ig)-like constant domain in Robo (roundabout) receptors, and similar domains
      cd20952
      Location:423 → 509
      IgI_5_Robo; Fifth Ig-like domain of Roundabout (Robo) homolog 1/2, and similar domains; a member of the I-set of IgSF domains
      cl11960
      Location:136 → 221
      Ig; Immunoglobulin domain

    23. NM_001395657.1 → NP_001382586.1  roundabout homolog 2 isoofrm 24 precursor

      Status: REVIEWED

      Source sequence(s)
      AC067717, AC117515, AC117516, AC133040
      Conserved Domains (2) summary
      smart00409
      Location:447 → 528
      IG; Immunoglobulin
      cd00063
      Location:545 → 638
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

    24. NM_002942.5 → NP_002933.1  roundabout homolog 2 isoform ROBO2b precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks two alternate in-frame exons in the coding region compared to variant 4. The encoded protein (isoform ROBO2b; PMID 16829019) is shorter than variant 4.
      Source sequence(s)
      AC117515, AC133040, DQ533874
      Consensus CDS
      CCDS43109.1
      UniProtKB/Swiss-Prot
      O43608, Q19AB4, Q19AB5, Q9HCK4
      Related
      ENSP00000417164.1, ENST00000461745.5
      Conserved Domains (5) summary
      cd05726
      Location:328 → 417
      Ig4_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
      cd07693
      Location:30 → 129
      Ig1_Robo; First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins
      smart00409
      Location:424 → 505
      IG; Immunoglobulin
      cd00063
      Location:522 → 615
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cl11960
      Location:137 → 221
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      75906675..77649964
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047448673.1 → XP_047304629.1  roundabout homolog 2 isoform X11

    2. XM_011533981.3 → XP_011532283.1  roundabout homolog 2 isoform X1

      Conserved Domains (6) summary
      cd05726
      Location:355 → 444
      Ig4_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
      cd07693
      Location:53 → 152
      Ig1_Robo; First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins
      smart00409
      Location:451 → 532
      IG; Immunoglobulin
      cd00063
      Location:549 → 642
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam16599
      Location:1374 → 1431
      PTN13_u3; Unstructured linker region on PTN13 protein between PDZ
      cl11960
      Location:160 → 244
      Ig; Immunoglobulin domain

    3. XM_011533983.2 → XP_011532285.1  roundabout homolog 2 isoform X5

      Conserved Domains (6) summary
      cd00063
      Location:549 → 642
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00096
      Location:159 → 162
      Ig; Ig strand A [structural motif]
      cd05726
      Location:342 → 439
      IgI_4_Robo; Fourth immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of Ig superfamily (IgSF) domains
      cd07693
      Location:54 → 152
      IgC_1_Robo; First immunoglobulin (Ig)-like constant domain in Robo (roundabout) receptors, and similar domains
      cd20952
      Location:446 → 532
      IgI_5_Robo; Fifth Ig-like domain of Roundabout (Robo) homolog 1/2, and similar domains; a member of the I-set of IgSF domains
      cl11960
      Location:159 → 244
      Ig; Immunoglobulin domain

    4. XM_017006988.2 → XP_016862477.1  roundabout homolog 2 isoform X6

      Conserved Domains (6) summary
      cd00063
      Location:549 → 642
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00096
      Location:159 → 162
      Ig; Ig strand A [structural motif]
      cd05726
      Location:342 → 439
      IgI_4_Robo; Fourth immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of Ig superfamily (IgSF) domains
      cd07693
      Location:54 → 152
      IgC_1_Robo; First immunoglobulin (Ig)-like constant domain in Robo (roundabout) receptors, and similar domains
      cd20952
      Location:446 → 532
      IgI_5_Robo; Fifth Ig-like domain of Roundabout (Robo) homolog 1/2, and similar domains; a member of the I-set of IgSF domains
      cl11960
      Location:159 → 244
      Ig; Immunoglobulin domain

    5. XM_017006994.2 → XP_016862483.1  roundabout homolog 2 isoform X12

    6. XM_011533982.2 → XP_011532284.1  roundabout homolog 2 isoform X3

      Conserved Domains (7) summary
      cd00096
      Location:462 → 529
      Ig; Immunoglobulin domain
      cd05726
      Location:355 → 444
      Ig4_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
      cd07693
      Location:53 → 152
      Ig1_Robo; First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins
      smart00410
      Location:451 → 532
      IG_like; Immunoglobulin like
      cd00063
      Location:549 → 642
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:248 → 333
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:160 → 244
      Ig; Immunoglobulin domain

    7. XM_047448672.1 → XP_047304628.1  roundabout homolog 2 isoform X10

    8. XM_047448674.1 → XP_047304630.1  roundabout homolog 2 isoform X13

    9. XM_017006987.2 → XP_016862476.1  roundabout homolog 2 isoform X4

    10. XM_047448671.1 → XP_047304627.1  roundabout homolog 2 isoform X9

    11. XM_017007002.2 → XP_016862491.1  roundabout homolog 2 isoform X15

    12. XM_047448676.1 → XP_047304632.1  roundabout homolog 2 isoform X14

    13. XM_047448677.1 → XP_047304633.1  roundabout homolog 2 isoform X16

    14. XM_017006986.2 → XP_016862475.1  roundabout homolog 2 isoform X2

      Conserved Domains (7) summary
      cd00096
      Location:439 → 506
      Ig; Immunoglobulin domain
      cd05726
      Location:332 → 421
      Ig4_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
      cd07693
      Location:30 → 129
      Ig1_Robo; First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins
      smart00410
      Location:428 → 509
      IG_like; Immunoglobulin like
      cd00063
      Location:526 → 619
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:225 → 310
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:137 → 221
      Ig; Immunoglobulin domain

    15. XM_047448670.1 → XP_047304626.1  roundabout homolog 2 isoform X8

    16. XM_047448669.1 → XP_047304625.1  roundabout homolog 2 isoform X7

    17. XM_047448678.1 → XP_047304634.1  roundabout homolog 2 isoform X17

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      75959914..77704808
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054347467.1 → XP_054203442.1  roundabout homolog 2 isoform X11

    2. XM_054347457.1 → XP_054203432.1  roundabout homolog 2 isoform X1

    3. XM_054347461.1 → XP_054203436.1  roundabout homolog 2 isoform X5

    4. XM_054347462.1 → XP_054203437.1  roundabout homolog 2 isoform X6

    5. XM_054347468.1 → XP_054203443.1  roundabout homolog 2 isoform X12

    6. XM_054347459.1 → XP_054203434.1  roundabout homolog 2 isoform X3

    7. XM_054347466.1 → XP_054203441.1  roundabout homolog 2 isoform X10

    8. XM_054347469.1 → XP_054203444.1  roundabout homolog 2 isoform X13

    9. XM_054347460.1 → XP_054203435.1  roundabout homolog 2 isoform X4

    10. XM_054347465.1 → XP_054203440.1  roundabout homolog 2 isoform X9

    11. XM_054347471.1 → XP_054203446.1  roundabout homolog 2 isoform X15

    12. XM_054347470.1 → XP_054203445.1  roundabout homolog 2 isoform X14

    13. XM_054347472.1 → XP_054203447.1  roundabout homolog 2 isoform X16

    14. XM_054347458.1 → XP_054203433.1  roundabout homolog 2 isoform X2

    15. XM_054347464.1 → XP_054203439.1  roundabout homolog 2 isoform X8

    16. XM_054347463.1 → XP_054203438.1  roundabout homolog 2 isoform X7

    17. XM_054347473.1 → XP_054203448.1  roundabout homolog 2 isoform X17

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9HCK4.2 GenPept UniProtKB/Swiss-Prot:Q9HCK4

    Gene LinkOut

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