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    Ogn osteoglycin [ Rattus norvegicus (Norway rat) ]

    Gene ID: 291015, updated on 9-Dec-2024

    Summary

    Symbol
    Ognprovided by RGD
    Full Name
    osteoglycinprovided by RGD
    Primary source
    RGD:1308171
    See related
    EnsemblRapid:ENSRNOG00000029792 AllianceGenome:RGD:1308171
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable growth factor activity. Involved in negative regulation of smooth muscle cell proliferation. Predicted to be located in endoplasmic reticulum. Predicted to be active in extracellular matrix. Orthologous to human OGN (osteoglycin). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 851.8), Lung (RPKM 538.7) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Ogn in Genome Data Viewer
    Location:
    17p14
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (15238500..15259167, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (15032069..15052626, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (14607442..14628274, complement)

    Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene isoleucyl-tRNA synthetase 1 Neighboring gene small nucleolar RNA SNORA84 Neighboring gene nucleolar protein 8 Neighboring gene centromere protein P Neighboring gene 60S ribosomal protein L7a pseudogene Neighboring gene osteomodulin Neighboring gene asporin

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    General gene information

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in articular cartilage development  
    involved_in bone development  
    involved_in negative regulation of smooth muscle cell proliferation PubMed 
    involved_in signal transduction  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum  
    is_active_in extracellular matrix  
    located_in extracellular region  

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106103.1NP_001099573.1  mimecan precursor

      See identical proteins and their annotated locations for NP_001099573.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473977
      UniProtKB/TrEMBL
      A6J6V8, D3ZVB7
      Related
      ENSRNOP00000020532.5, ENSRNOT00000020532.9
      Conserved Domains (2) summary
      sd00033
      Location:123144
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:143225
      LRR_8; Leucine rich repeat

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086035.1 Reference GRCr8

      Range
      15238500..15259167 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008771490.4XP_008769712.1  mimecan isoform X1

      See identical proteins and their annotated locations for XP_008769712.1

      UniProtKB/TrEMBL
      A0A1W2Q6Q0
      Related
      ENSRNOP00000110107.1, ENSRNOT00000171835.1
      Conserved Domains (4) summary
      cd00116
      Location:249352
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:229250
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:249331
      LRR_8; Leucine rich repeat
      pfam15376
      Location:167264
      DUF4603; Domain of unknown function (DUF4603)
    2. XM_063276149.1XP_063132219.1  mimecan isoform X1

      UniProtKB/TrEMBL
      A0A1W2Q6Q0
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