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    Prdx4 peroxiredoxin 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 85274, updated on 9-Dec-2024

    Summary

    Official Symbol
    Prdx4provided by RGD
    Official Full Name
    peroxiredoxin 4provided by RGD
    Primary source
    RGD:620043
    See related
    EnsemblRapid:ENSRNOG00000003763 AllianceGenome:RGD:620043
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable several functions, including identical protein binding activity; molecular sequestering activity; and thioredoxin peroxidase activity. Predicted to be involved in cell redox homeostasis; hydrogen peroxide catabolic process; and response to oxidative stress. Predicted to act upstream of or within several processes, including negative regulation of male germ cell proliferation; peptidyl-proline hydroxylation to 4-hydroxy-L-proline; and protein maturation by protein folding. Located in extracellular space and smooth endoplasmic reticulum. Orthologous to human PRDX4 (peroxiredoxin 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Liver (RPKM 657.7), Testes (RPKM 250.7) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Prdx4 in Genome Data Viewer
    Location:
    Xq21
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (43876374..43893815)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (40026762..40044066)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (43495453..43512994)

    Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene patched domain containing 1 Neighboring gene MAGE family member A8 Neighboring gene E3 ubiquitin-protein ligase RNF168-like Neighboring gene acyl-CoA thioesterase 9

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    General gene information

    Clone Names

    • MGC72744

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables antioxidant activity  
    enables identical protein binding  
    enables identical protein binding  
    enables molecular adaptor activity  
    enables molecular sequestering activity  
    enables molecular sequestering activity  
    enables oxidoreductase activity  
    enables peroxiredoxin activity  
    enables thioredoxin peroxidase activity  
    Process Evidence Code Pubs
    involved_in cell redox homeostasis  
    involved_in cell redox homeostasis  
    acts_upstream_of_or_within cell redox homeostasis  
    involved_in cellular oxidant detoxification  
    involved_in extracellular matrix organization  
    acts_upstream_of_or_within extracellular matrix organization  
    involved_in hydrogen peroxide catabolic process  
    involved_in male gonad development  
    acts_upstream_of_or_within male gonad development  
    involved_in negative regulation of male germ cell proliferation  
    acts_upstream_of_or_within negative regulation of male germ cell proliferation  
    acts_upstream_of_or_within peptidyl-proline hydroxylation to 4-hydroxy-L-proline  
    involved_in protein maturation by protein folding  
    acts_upstream_of_or_within protein maturation by protein folding  
    involved_in reactive oxygen species metabolic process  
    acts_upstream_of_or_within reactive oxygen species metabolic process  
    involved_in response to oxidative stress  
    involved_in response to oxidative stress  
    acts_upstream_of_or_within response to oxidative stress  
    involved_in spermatogenesis  
    acts_upstream_of_or_within spermatogenesis  
    Component Evidence Code Pubs
    located_in cytoplasm  
    is_active_in cytosol  
    located_in cytosol  
    located_in cytosol  
    is_active_in endoplasmic reticulum  
    located_in endoplasmic reticulum  
    located_in endoplasmic reticulum  
    located_in extracellular space PubMed 
    located_in smooth endoplasmic reticulum PubMed 

    General protein information

    Preferred Names
    peroxiredoxin-4
    Names
    antioxidant enzyme AOE372
    peroxiredoxin IV
    prx-IV
    thioredoxin peroxidase AO372
    thioredoxin-dependent peroxide reductase A0372
    thioredoxin-dependent peroxiredoxin 4
    NP_445964.1
    XP_006257013.1
    XP_017457660.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053512.2NP_445964.1  peroxiredoxin-4 precursor

      See identical proteins and their annotated locations for NP_445964.1

      Status: PROVISIONAL

      Source sequence(s)
      AF106945
      UniProtKB/Swiss-Prot
      Q9Z0V5
      UniProtKB/TrEMBL
      A6IPQ9
      Related
      ENSRNOP00000005014.5, ENSRNOT00000005014.6
      Conserved Domains (2) summary
      COG0450
      Location:83271
      AhpC; Alkyl hydroperoxide reductase subunit AhpC (peroxiredoxin) [Defense mechanisms]
      cd03015
      Location:83254
      PRX_Typ2cys; Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides. ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086039.1 Reference GRCr8

      Range
      43876374..43893815
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006256951.5XP_006257013.1  peroxiredoxin-4 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AER1
      Related
      ENSRNOP00000086837.1, ENSRNOT00000105854.2
      Conserved Domains (2) summary
      COG0450
      Location:65255
      AhpC; Alkyl hydroperoxide reductase subunit AhpC (peroxiredoxin) [Defense mechanisms]
      cd03015
      Location:67238
      PRX_Typ2cys; Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides. ...
    2. XM_017602171.3XP_017457660.1  peroxiredoxin-4 isoform X2

      UniProtKB/TrEMBL
      A0A8L2Q1B0
      Related
      ENSRNOP00000080648.1, ENSRNOT00000114432.2
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