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    Serpinf1 serine (or cysteine) peptidase inhibitor, clade F, member 1 [ Mus musculus (house mouse) ]

    Gene ID: 20317, updated on 13-Jan-2025

    Summary

    Official Symbol
    Serpinf1provided by MGI
    Official Full Name
    serine (or cysteine) peptidase inhibitor, clade F, member 1provided by MGI
    Primary source
    MGI:MGI:108080
    See related
    Ensembl:ENSMUSG00000000753 AllianceGenome:MGI:108080
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pedf; Sdf3; EPC-1; Pedfl
    Summary
    Predicted to enable serine-type endopeptidase inhibitor activity. Involved in negative regulation of angiogenesis. Acts upstream of or within negative regulation of epithelial cell proliferation involved in prostate gland development. Located in extracellular space. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; heart; and sensory organ. Used to study osteogenesis imperfecta type 6. Human ortholog(s) of this gene implicated in several diseases, including bone disease (multiple); brain edema; eye disease (multiple); leukostasis; and metabolic dysfunction-associated steatohepatitis. Orthologous to human SERPINF1 (serpin family F member 1). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in liver adult (RPKM 193.9), mammary gland adult (RPKM 118.2) and 10 other tissues See more
    Orthologs
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    Genomic context

    See Serpinf1 in Genome Data Viewer
    Location:
    11 B5; 11 45.87 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (75300855..75313449, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (75410029..75422623, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene reticulon 4 receptor-like 1 Neighboring gene predicted gene, 35117 Neighboring gene replication protein A1 Neighboring gene STARR-positive B cell enhancer ABC_E9826 Neighboring gene STARR-positive B cell enhancer ABC_E3972 Neighboring gene STARR-seq mESC enhancer starr_29990 Neighboring gene STARR-seq mESC enhancer starr_29991 Neighboring gene SET and MYND domain containing 4 Neighboring gene predicted gene, 35337 Neighboring gene predicted gene 12337

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (8) 
    • Targeted (6)  1 citation

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Items 1 - 25 of 28
    Process Evidence Code Pubs
    involved_in cellular response to cobalt ion  
    involved_in cellular response to dexamethasone stimulus  
    involved_in cellular response to glucose stimulus  
    involved_in cellular response to retinoic acid  
    acts_upstream_of epithelial cell proliferation involved in prostate gland development PubMed 
    involved_in kidney development  
    involved_in negative regulation of angiogenesis  
    involved_in negative regulation of angiogenesis PubMed 
    involved_in negative regulation of angiogenesis  
    involved_in negative regulation of endopeptidase activity  
    involved_in negative regulation of endothelial cell migration  
    involved_in negative regulation of endothelial cell migration  
    acts_upstream_of_or_within negative regulation of epithelial cell proliferation involved in prostate gland development PubMed 
    involved_in negative regulation of gene expression  
    involved_in negative regulation of gene expression  
    involved_in ovulation cycle  
    involved_in positive regulation of neurogenesis  
    involved_in positive regulation of neurogenesis  
    involved_in positive regulation of neuron projection development  
    involved_in positive regulation of neuron projection development  
    involved_in response to acidic pH  
    involved_in response to arsenic-containing substance  
    involved_in response to organic cyclic compound  
    involved_in response to peptide  
    involved_in response to peptide  
    involved_in retina development in camera-type eye  
    involved_in short-term memory  
    involved_in short-term memory  
    Items 1 - 25 of 28
    Component Evidence Code Pubs
    located_in axon  
    located_in axon hillock  
    located_in axon hillock  
    located_in basement membrane  
    located_in basement membrane  
    located_in extracellular region PubMed 
    located_in extracellular region  
    located_in extracellular space PubMed 
    is_active_in extracellular space  
    located_in extracellular space PubMed 
    located_in extracellular space  
    located_in melanosome  
    located_in neuronal cell body  
    located_in perinuclear region of cytoplasm  
    located_in perinuclear region of cytoplasm  

    General protein information

    Preferred Names
    pigment epithelium-derived factor
    Names
    SDF-3
    alpha-2 antiplasmin
    caspin
    serine (or cysteine) proteinase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
    serine (or cysteine) proteinase inhibitor, clade F), member 1
    serine (or cysteine) proteinase inhibitor, clade F, member 1
    serpin F1
    stromal cell-derived factor 3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011340.3NP_035470.3  pigment epithelium-derived factor precursor

      See identical proteins and their annotated locations for NP_035470.3

      Status: VALIDATED

      Source sequence(s)
      AA111321, AF017057, AL591496, D50460
      Consensus CDS
      CCDS25045.1
      UniProtKB/Swiss-Prot
      O70629, O88691, P97298
      Related
      ENSMUSP00000000769.8, ENSMUST00000000769.14
      Conserved Domains (1) summary
      cd02052
      Location:39414
      PEDF; Pigment epithelium-derived factor (PEDF)_like. PEDF is non-inhibitory member of the Serpin superfamily. It exhibits neurotrophic, neuroprotective and antiangiogenic properties and is widely expressed in the developing and adult nervous systems. This ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      75300855..75313449 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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