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    Boc BOC cell adhesion associated, oncogene regulated [ Mus musculus (house mouse) ]

    Gene ID: 117606, updated on 4-Jan-2025

    Summary

    Official Symbol
    Bocprovided by MGI
    Official Full Name
    BOC cell adhesion associated, oncogene regulatedprovided by MGI
    Primary source
    MGI:MGI:2151153
    See related
    Ensembl:ENSMUSG00000022687 AllianceGenome:MGI:2151153
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mFLJ00376; 4732455C11
    Summary
    Involved in positive regulation of myoblast differentiation. Acts upstream of or within axon guidance and smoothened signaling pathway. Located in growth cone and neuronal cell body. Is expressed in several structures, including alimentary system; brain; embryo mesenchyme; genitourinary system; and sensory organ. Orthologous to human BOC (BOC cell adhesion associated, oncogene regulated). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Broad expression in adrenal adult (RPKM 42.5), limb E14.5 (RPKM 40.8) and 18 other tissues See more
    Orthologs
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    Genomic context

    See Boc in Genome Data Viewer
    Location:
    16 B4; 16 28.81 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (44305408..44379233, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (44485045..44558870, complement)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_40899 Neighboring gene spindle and centriole associated protein 1 Neighboring gene STARR-seq mESC enhancer starr_40902 Neighboring gene cilia and flagella associated protein 44 Neighboring gene STARR-seq mESC enhancer starr_40903 Neighboring gene STARR-seq mESC enhancer starr_40904 Neighboring gene Boc Hedgehog-responsive enhancer Neighboring gene STARR-seq mESC enhancer starr_40905 Neighboring gene VISTA enhancer mm1504 Neighboring gene predicted gene, 30064 Neighboring gene STARR-seq mESC enhancer starr_40907 Neighboring gene microRNA 3081 Neighboring gene ribosomal protein L27A, pseudogene 3 Neighboring gene predicted gene, 30252

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (6)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Clone Names

    • DKFZp434L072

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    is_active_in axon  
    located_in axon PubMed 
    located_in axonal growth cone  
    located_in cell surface PubMed 
    located_in growth cone PubMed 
    located_in neuronal cell body PubMed 
    located_in plasma membrane PubMed 
    located_in plasma membrane  

    General protein information

    Preferred Names
    brother of CDO
    Names
    biregional Cdon binding protein
    biregional cell adhesion molecule-related/down-regulated by oncogenes (Cdon) binding protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_172506.2NP_766094.1  brother of CDO precursor

      See identical proteins and their annotated locations for NP_766094.1

      Status: PROVISIONAL

      Source sequence(s)
      AK028889
      Consensus CDS
      CCDS28186.1
      UniProtKB/Swiss-Prot
      Q6AZB0, Q6KAM5, Q6P5H3, Q7TMJ3, Q8CE73, Q8CE91, Q8R377, Q923W7
      UniProtKB/TrEMBL
      D3Z763
      Related
      ENSMUSP00000110281.3, ENSMUST00000114634.3
      Conserved Domains (7) summary
      smart00408
      Location:332393
      IGc2; Immunoglobulin C-2 Type
      smart00060
      Location:481553
      FN3; Fibronectin type 3 domain
      smart00410
      Location:132207
      IG_like; Immunoglobulin like
      cd00063
      Location:601692
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:318401
      I-set; Immunoglobulin I-set domain
      pfam16625
      Location:404468
      ISET-FN3_linker; Unstructured linking region I-set and fnIII on Brother of CDO
      cl11960
      Location:243301
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      44305408..44379233 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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