U.S. flag

An official website of the United States government

Links from GEO Profiles

    • Showing Current items.

    Sik2 salt inducible kinase 2 [ Mus musculus (house mouse) ]

    Gene ID: 235344, updated on 4-Jan-2025

    Summary

    Official Symbol
    Sik2provided by MGI
    Official Full Name
    salt inducible kinase 2provided by MGI
    Primary source
    MGI:MGI:2445031
    See related
    Ensembl:ENSMUSG00000037112 AllianceGenome:MGI:2445031
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Snf1lk2; G630080D20Rik
    Summary
    Enables ATP binding activity; magnesium ion binding activity; and protein kinase activity. Involved in several processes, including protein phosphorylation; regulation of insulin receptor signaling pathway; and regulation of primary metabolic process. Acts upstream of or within insulin receptor signaling pathway. Located in cytoplasm and nucleus. Is expressed in cerebral cortex ventricular layer; cortical plate; and heart. Orthologous to human SIK2 (salt inducible kinase 2). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Broad expression in subcutaneous fat pad adult (RPKM 39.2), mammary gland adult (RPKM 30.6) and 24 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Sik2 in Genome Data Viewer
    Location:
    9 A5.3; 9 27.75 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (50800944..50920432, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (50889644..51009132, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene ALG9 alpha-1,2-mannosyltransferase Neighboring gene predicted gene, 57547 Neighboring gene STARR-seq mESC enhancer starr_24122 Neighboring gene STARR-positive B cell enhancer mm9_chr9:50664895-50665195 Neighboring gene protein phosphatase 2, regulatory subunit A, beta Neighboring gene predicted gene, 25558 Neighboring gene STARR-seq mESC enhancer starr_24123 Neighboring gene STARR-seq mESC enhancer starr_24124 Neighboring gene STARR-positive B cell enhancer ABC_E8290 Neighboring gene predicted gene, 32681 Neighboring gene layilin Neighboring gene HOATZ cilia and flagella associated protein Neighboring gene microRNA 34c Neighboring gene BTG anti-proliferation factor 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Items 1 - 25 of 31
    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity  
    enables AMP-activated protein kinase activity  
    enables ATP binding PubMed 
    enables ATP binding  
    enables DNA-dependent protein kinase activity  
    enables Rho-dependent protein serine/threonine kinase activity  
    enables eukaryotic translation initiation factor 2alpha kinase activity  
    enables histone H2AS1 kinase activity  
    enables histone H2AS121 kinase activity  
    enables histone H2AT120 kinase activity  
    enables histone H2AXS139 kinase activity  
    enables histone H2BS14 kinase activity  
    enables histone H2BS36 kinase activity  
    enables histone H3S10 kinase activity  
    enables histone H3S28 kinase activity  
    enables histone H3S57 kinase activity  
    enables histone H3T11 kinase activity  
    enables histone H3T3 kinase activity  
    enables histone H3T45 kinase activity  
    enables histone H3T6 kinase activity  
    enables histone H4S1 kinase activity  
    enables magnesium ion binding PubMed 
    enables magnesium ion binding  
    enables protein binding PubMed 
    enables protein serine kinase activity PubMed 
    enables protein serine kinase activity PubMed 
    enables protein serine kinase activity  
    enables protein serine/threonine kinase activity  
    enables protein serine/threonine kinase activity PubMed 
    enables protein serine/threonine kinase activity  
    enables ribosomal protein S6 kinase activity  
    Items 1 - 25 of 31
    Process Evidence Code Pubs
    involved_in chromatin remodeling  
    acts_upstream_of_or_within insulin receptor signaling pathway PubMed 
    involved_in intracellular signal transduction  
    involved_in intracellular signal transduction PubMed 
    involved_in intracellular signal transduction  
    involved_in negative regulation of glycolytic process PubMed 
    involved_in negative regulation of lipid biosynthetic process PubMed 
    involved_in negative regulation of transcription from RNA polymerase II promoter by glucose PubMed 
    involved_in negative regulation of transcription from RNA polymerase II promoter by glucose PubMed 
    involved_in protein autophosphorylation  
    involved_in protein autophosphorylation  
    acts_upstream_of_or_within protein phosphorylation PubMed 
    involved_in protein phosphorylation PubMed 
    involved_in protein phosphorylation  
    involved_in regulation of insulin receptor signaling pathway PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm  
    located_in cytoplasm PubMed 
    is_active_in endoplasmic reticulum membrane  
    is_active_in nucleus  
    located_in nucleus PubMed 

    General protein information

    Preferred Names
    serine/threonine-protein kinase SIK2
    Names
    SIK-2
    SNF1-like kinase 2
    salt induceable kinase 2
    salt-inducible protein kinase 2
    serine/threonine-protein kinase SNF1-like kinase 2
    NP_001391943.1
    NP_001391944.1
    NP_848825.2
    XP_006510330.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001405014.1NP_001391943.1  serine/threonine-protein kinase SIK2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC103406
      UniProtKB/Swiss-Prot
      Q8CFH6
      UniProtKB/TrEMBL
      H3BKG1
      Related
      ENSMUSP00000135376.2, ENSMUST00000176663.8
    2. NM_001405015.1NP_001391944.1  serine/threonine-protein kinase SIK2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC103406
      UniProtKB/Swiss-Prot
      Q8CFH6
    3. NM_178710.4NP_848825.2  serine/threonine-protein kinase SIK2 isoform 1

      See identical proteins and their annotated locations for NP_848825.2

      Status: VALIDATED

      Source sequence(s)
      AC103406
      Consensus CDS
      CCDS40627.1
      UniProtKB/Swiss-Prot
      Q8CFH6
      UniProtKB/TrEMBL
      F8VPT7
      Related
      ENSMUSP00000038761.11, ENSMUST00000041375.11
      Conserved Domains (3) summary
      smart00220
      Location:20271
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14409
      Location:297341
      UBA_SIK2; UBA domain found in salt-inducible kinase 2 (SIK2)
      cd14071
      Location:19271
      STKc_SIK; Catalytic domain of the Serine/Threonine Kinases, Salt-Inducible kinases

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      50800944..50920432 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006510267.3XP_006510330.1  serine/threonine-protein kinase SIK2 isoform X2

      UniProtKB/Swiss-Prot
      Q8CFH6
      Conserved Domains (2) summary
      cd14409
      Location:297341
      UBA_SIK2; UBA domain found in salt-inducible kinase 2 (SIK2)
      cd14071
      Location:19271
      STKc_SIK; Catalytic domain of the Serine/Threonine Kinases, Salt-Inducible kinases

    RNA

    1. XR_379116.2 RNA Sequence

    External link. Please review our privacy policy.