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    Stat1 signal transducer and activator of transcription 1 [ Mus musculus (house mouse) ]

    Gene ID: 20846, updated on 4-Jan-2025

    Summary

    Official Symbol
    Stat1provided by MGI
    Official Full Name
    signal transducer and activator of transcription 1provided by MGI
    Primary source
    MGI:MGI:103063
    See related
    Ensembl:ENSMUSG00000026104 AllianceGenome:MGI:103063
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2010005J02Rik
    Summary
    Enables DNA-binding transcription factor activity, RNA polymerase II-specific. Involved in cell population proliferation; cell surface receptor signaling pathway via JAK-STAT; and defense response to symbiont. Acts upstream of or within with a positive effect on positive regulation of apoptotic process. Acts upstream of or within several processes, including cell surface receptor signaling pathway; negative regulation of macrophage fusion; and response to exogenous dsRNA. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; hemolymphoid system gland; and skeletal musculature. Used to study breast cancer and severe acute respiratory syndrome. Human ortholog(s) of this gene implicated in adenocarcinoma (multiple); breast carcinoma; immunodeficiency 31A; immunodeficiency 31B; and immunodeficiency 31C. Orthologous to human STAT1 (signal transducer and activator of transcription 1). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Ubiquitous expression in thymus adult (RPKM 23.3), spleen adult (RPKM 19.5) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Stat1 in Genome Data Viewer
    Location:
    1 C1.1; 1 26.81 cM
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (52158588..52201024)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (52119438..52161865)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene signal transducer and activator of transcription 4 Neighboring gene STARR-seq mESC enhancer starr_00894 Neighboring gene ribosomal protein L23A pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E10010 Neighboring gene predicted gene, 31812 Neighboring gene STARR-positive B cell enhancer ABC_E3272 Neighboring gene STARR-positive B cell enhancer ABC_E3273 Neighboring gene transmembrane protein 209 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E7722 Neighboring gene glutaminase Neighboring gene STARR-positive B cell enhancer ABC_E1992 Neighboring gene predicted gene, 31867

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by MGI

    Items 1 - 25 of 31
    Function Evidence Code Pubs
    enables CCR5 chemokine receptor binding  
    enables DNA binding  
    enables DNA binding  
    enables DNA-binding transcription factor activity PubMed 
    enables DNA-binding transcription factor activity  
    enables DNA-binding transcription factor activity PubMed 
    enables DNA-binding transcription factor activity  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding  
    enables RNA polymerase II core promoter sequence-specific DNA binding  
    enables RNA polymerase II core promoter sequence-specific DNA binding  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding  
    enables double-stranded DNA binding  
    enables enzyme binding  
    enables histone acetyltransferase binding  
    enables histone binding  
    enables identical protein binding  
    enables nuclear receptor binding  
    enables promoter-specific chromatin binding  
    enables protein binding PubMed 
    enables protein homodimerization activity  
    enables protein homodimerization activity  
    enables protein phosphatase 2A binding  
    enables sequence-specific DNA binding  
    enables transcription coactivator binding  
    enables transcription corepressor binding  
    enables tumor necrosis factor receptor binding  
    enables ubiquitin-like protein ligase binding  
    Items 1 - 25 of 31
    Items 1 - 25 of 64
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA-templated transcription PubMed 
    involved_in blood circulation  
    involved_in cell population proliferation PubMed 
    involved_in cell surface receptor signaling pathway via JAK-STAT  
    involved_in cell surface receptor signaling pathway via JAK-STAT PubMed 
    involved_in cell surface receptor signaling pathway via JAK-STAT  
    acts_upstream_of_or_within cellular response to cytokine stimulus PubMed 
    involved_in cellular response to interferon-beta  
    acts_upstream_of_or_within cellular response to lipopolysaccharide PubMed 
    acts_upstream_of_or_within cellular response to organic cyclic compound PubMed 
    involved_in cellular response to type II interferon  
    acts_upstream_of_or_within cytokine-mediated signaling pathway PubMed 
    involved_in cytokine-mediated signaling pathway  
    involved_in defense response  
    involved_in defense response to virus PubMed 
    involved_in defense response to virus  
    involved_in defense response to virus  
    involved_in interleukin-27-mediated signaling pathway  
    involved_in interleukin-9-mediated signaling pathway  
    acts_upstream_of_or_within lipopolysaccharide-mediated signaling pathway PubMed 
    involved_in macrophage derived foam cell differentiation  
    involved_in metanephric mesenchymal cell differentiation  
    involved_in metanephric mesenchymal cell proliferation involved in metanephros development  
    involved_in negative regulation by virus of viral protein levels in host cell  
    involved_in negative regulation of angiogenesis  
    involved_in negative regulation of canonical NF-kappaB signal transduction  
    involved_in negative regulation of endothelial cell proliferation  
    acts_upstream_of_or_within negative regulation of macrophage fusion PubMed 
    involved_in negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis  
    involved_in negative regulation of metanephric nephron tubule epithelial cell differentiation  
    involved_in negative regulation of transcription by RNA polymerase II  
    involved_in positive regulation of DNA-templated transcription  
    acts_upstream_of_or_within_positive_effect positive regulation of apoptotic process PubMed 
    involved_in positive regulation of defense response to virus by host  
    involved_in positive regulation of erythrocyte differentiation  
    involved_in positive regulation of erythrocyte differentiation  
    involved_in positive regulation of interferon-alpha production  
    involved_in positive regulation of interferon-alpha production  
    involved_in positive regulation of mesenchymal cell proliferation  
    involved_in positive regulation of smooth muscle cell proliferation  
    involved_in positive regulation of transcription by RNA polymerase II  
    involved_in positive regulation of transcription by RNA polymerase II  
    involved_in regulation of DNA-templated transcription  
    involved_in regulation of cell population proliferation  
    involved_in regulation of transcription by RNA polymerase II  
    involved_in regulation of transcription by RNA polymerase II  
    involved_in renal tubule development  
    acts_upstream_of_or_within response to bacterium PubMed 
    involved_in response to cAMP  
    involved_in response to cytokine  
    acts_upstream_of_or_within response to exogenous dsRNA PubMed 
    involved_in response to interferon-beta  
    acts_upstream_of_or_within response to lipopolysaccharide PubMed 
    involved_in response to peptide hormone  
    involved_in response to peptide hormone  
    involved_in response to type I interferon PubMed 
    involved_in response to type II interferon PubMed 
    involved_in response to type II interferon  
    involved_in tumor necrosis factor-mediated signaling pathway  
    involved_in type I interferon-mediated signaling pathway  
    involved_in type I interferon-mediated signaling pathway PubMed 
    involved_in type I interferon-mediated signaling pathway  
    involved_in type II interferon-mediated signaling pathway PubMed 
    involved_in type II interferon-mediated signaling pathway  
    Items 1 - 25 of 64
    Items 1 - 20 of 24
    Component Evidence Code Pubs
    part_of ISGF3 complex  
    part_of ISGF3 complex  
    part_of RNA polymerase II transcription regulator complex  
    located_in axon  
    located_in axon  
    located_in chromatin  
    is_active_in cytoplasm  
    located_in cytoplasm PubMed 
    located_in cytoplasm  
    located_in cytoplasm  
    located_in cytosol  
    located_in cytosol  
    located_in dendrite  
    located_in dendrite  
    located_in nucleolus  
    located_in nucleoplasm  
    located_in nucleoplasm  
    located_in nucleus PubMed 
    located_in nucleus  
    colocalizes_with nucleus  
    is_active_in nucleus  
    located_in nucleus  
    located_in perinuclear region of cytoplasm  
    part_of protein-containing complex  
    Items 1 - 20 of 24

    General protein information

    Preferred Names
    signal transducer and activator of transcription 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001205313.1NP_001192242.1  signal transducer and activator of transcription 1 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC123752, AK046517, BC042551, BX513160
      Consensus CDS
      CCDS78581.1
      UniProtKB/TrEMBL
      A0A087WSP5, Q8C8M3
      Related
      ENSMUSP00000141132.2, ENSMUST00000186057.7
      Conserved Domains (5) summary
      cd10372
      Location:563713
      SH2_STAT1; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 1 proteins
      smart00964
      Location:2121
      STAT_int; STAT protein, protein interaction domain
      pfam01017
      Location:139315
      STAT_alpha; STAT protein, all-alpha domain
      pfam02864
      Location:317572
      STAT_bind; STAT protein, DNA binding domain
      pfam12162
      Location:721745
      STAT1_TAZ2bind; STAT1 TAZ2 binding domain
    2. NM_001205314.1NP_001192243.1  signal transducer and activator of transcription 1 isoform 2

      See identical proteins and their annotated locations for NP_001192243.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1. Variants 2, 3, and 4 encode the same isoform.
      Source sequence(s)
      AK039458, AK084855, BC042551, BX513160
      Consensus CDS
      CCDS56628.1
      UniProtKB/TrEMBL
      E9QK78, Q3TW11, Q8C3V4, Q9D323
      Related
      ENSMUSP00000140875.2, ENSMUST00000186857.7
      Conserved Domains (5) summary
      cd10372
      Location:557707
      SH2_STAT1; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 1 proteins
      smart00964
      Location:2121
      STAT_int; STAT protein, protein interaction domain
      cd16851
      Location:138313
      STAT1_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 1 (STAT1)
      cd16845
      Location:317477
      STAT1_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 1 (STAT1)
      pfam12162
      Location:715739
      STAT1_TAZ2bind; STAT1 TAZ2 binding domain
    3. NM_001357627.1NP_001344556.1  signal transducer and activator of transcription 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC123752
      Consensus CDS
      CCDS56628.1
      UniProtKB/TrEMBL
      E9QK78, Q3TW11, Q8C3V4, Q9D323
      Conserved Domains (5) summary
      cd10372
      Location:557707
      SH2_STAT1; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 1 proteins
      smart00964
      Location:2121
      STAT_int; STAT protein, protein interaction domain
      cd16851
      Location:138313
      STAT1_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 1 (STAT1)
      cd16845
      Location:317477
      STAT1_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 1 (STAT1)
      pfam12162
      Location:715739
      STAT1_TAZ2bind; STAT1 TAZ2 binding domain
    4. NM_009283.4NP_033309.3  signal transducer and activator of transcription 1 isoform 2

      See identical proteins and their annotated locations for NP_033309.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1. Variants 2, 3, and 4 encode the same isoform.
      Source sequence(s)
      AC123752, AK039458, AK082706, BC042551, BX513160
      Consensus CDS
      CCDS56628.1
      UniProtKB/TrEMBL
      E9QK78, Q3TW11, Q8C3V4, Q9D323
      Related
      ENSMUSP00000066743.8, ENSMUST00000070968.14
      Conserved Domains (5) summary
      cd10372
      Location:557707
      SH2_STAT1; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 1 proteins
      smart00964
      Location:2121
      STAT_int; STAT protein, protein interaction domain
      cd16851
      Location:138313
      STAT1_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 1 (STAT1)
      cd16845
      Location:317477
      STAT1_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 1 (STAT1)
      pfam12162
      Location:715739
      STAT1_TAZ2bind; STAT1 TAZ2 binding domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      52158588..52201024
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036163078.1XP_036018971.1  signal transducer and activator of transcription 1 isoform X2

      UniProtKB/TrEMBL
      Q3TW11, Q8C497, Q99K94, Q9D323
      Related
      ENSMUSP00000140518.2, ENSMUST00000186574.7
      Conserved Domains (4) summary
      cd10372
      Location:557707
      SH2_STAT1; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 1 proteins
      smart00964
      Location:2121
      STAT_int; STAT protein, protein interaction domain
      cd16851
      Location:138313
      STAT1_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 1 (STAT1)
      cd16845
      Location:317477
      STAT1_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 1 (STAT1)
    2. XM_017319463.3XP_017174952.1  signal transducer and activator of transcription 1 isoform X1

      UniProtKB/TrEMBL
      E9QK78, Q3TW11, Q8C3V4, Q9D323
      Conserved Domains (5) summary
      cd10372
      Location:557707
      SH2_STAT1; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 1 proteins
      smart00964
      Location:2121
      STAT_int; STAT protein, protein interaction domain
      cd16851
      Location:138313
      STAT1_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 1 (STAT1)
      cd16845
      Location:317477
      STAT1_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 1 (STAT1)
      pfam12162
      Location:715739
      STAT1_TAZ2bind; STAT1 TAZ2 binding domain
    3. XM_030252467.2XP_030108327.1  signal transducer and activator of transcription 1 isoform X1

      UniProtKB/TrEMBL
      E9QK78, Q3TW11, Q8C3V4, Q9D323
      Conserved Domains (5) summary
      cd10372
      Location:557707
      SH2_STAT1; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 1 proteins
      smart00964
      Location:2121
      STAT_int; STAT protein, protein interaction domain
      cd16851
      Location:138313
      STAT1_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 1 (STAT1)
      cd16845
      Location:317477
      STAT1_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 1 (STAT1)
      pfam12162
      Location:715739
      STAT1_TAZ2bind; STAT1 TAZ2 binding domain
    4. XM_017319464.3XP_017174953.1  signal transducer and activator of transcription 1 isoform X1

      UniProtKB/TrEMBL
      E9QK78, Q3TW11, Q8C3V4, Q9D323
      Conserved Domains (5) summary
      cd10372
      Location:557707
      SH2_STAT1; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 1 proteins
      smart00964
      Location:2121
      STAT_int; STAT protein, protein interaction domain
      cd16851
      Location:138313
      STAT1_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 1 (STAT1)
      cd16845
      Location:317477
      STAT1_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 1 (STAT1)
      pfam12162
      Location:715739
      STAT1_TAZ2bind; STAT1 TAZ2 binding domain

    RNA

    1. XR_003954297.2 RNA Sequence

    2. XR_003954298.2 RNA Sequence

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