Ctbs chitobiase [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ctbsprovided by MGI
Official Full Name: chitobiaseprovided by MGI
Primary source: MGI:MGI:1921495
See related: Ensembl:ENSMUSG00000028189 AllianceGenome:MGI:1921495
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CTB; 2210401K11Rik
Summary: Predicted to enable chitinase activity. Predicted to be involved in chitin catabolic process and oligosaccharide catabolic process. Predicted to be located in lysosome. Is expressed in ventricular layer. Orthologous to human CTBS (chitobiase). [provided by Alliance of Genome Resources, Jan 2025]
Expression: Ubiquitous expression in testis adult (RPKM 4.4), kidney adult (RPKM 3.6) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 H2; 3 71.26 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (146156204..146171604)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (146450449..146465849)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

In di-N-acetylchitobiase-deficient mice Man2GlcNAc2 urine levels were up to 10-fold higher than in urine of wild-type animals.
Title: Lysosomal di-N-acetylchitobiase-deficient mouse tissues accumulate Man2GlcNAc2 and Man3GlcNAc2.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (1) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables chitin binding	IEA Inferred from Electronic Annotation more info
enables chitinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables chitinase activity	IEA Inferred from Electronic Annotation more info
enables chitinase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in chitin catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in chitin catabolic process	IEA Inferred from Electronic Annotation more info
involved_in chitin catabolic process	ISO Inferred from Sequence Orthology more info
involved_in oligosaccharide catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in oligosaccharide catabolic process	IEA Inferred from Electronic Annotation more info
involved_in oligosaccharide catabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in lysosome	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: di-N-acetylchitobiase

Names: chitobiase, di-N-acetyl-

NP_001280601.1

EC 3.2.1.-

NP_083112.1

EC 3.2.1.-

XP_030108705.1

EC 3.2.1.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001293672.2 → NP_001280601.1 di-N-acetylchitobiase isoform 1 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AC124987

Consensus CDS

CCDS80048.1

UniProtKB/Swiss-Prot

Q8R242, Q9D7V4

UniProtKB/TrEMBL

Q102J0

Related

ENSMUSP00000059167.7, ENSMUST00000061937.13

Conserved Domains (2) summary

cd02875
Location:24 → 362

GH18_chitobiase; Chitobiase (also known as di-N-acetylchitobiase) is a lysosomal glycosidase that hydrolyzes the reducing-end N-acetylglucosamine from the chitobiose core of oligosaccharides during the ordered degradation of asparagine-linked glycoproteins in eukaryotes. ...

smart00636
Location:99 → 342

Glyco_18; Glyco_18 domain
NM_028836.5 → NP_083112.1 di-N-acetylchitobiase isoform 2 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.

Source sequence(s)

AC124987

Consensus CDS

CCDS17902.1

UniProtKB/Swiss-Prot

Q8R242

Related

ENSMUSP00000029840.4, ENSMUST00000029840.4

Conserved Domains (2) summary

smart00636
Location:99 → 288

Glyco_18; Glyco_18 domain

cl10447
Location:24 → 308

GH18_chitinase-like; The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have ...

RNA

NR_190655.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC124987

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000069.7 Reference GRCm39 C57BL/6J

Range

146156204..146171604

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030252845.1 → XP_030108705.1 di-N-acetylchitobiase isoform X1

Conserved Domains (1) summary

cl10447
Location:1 → 244

GH18_chitinase-like; The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have ...