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    Otud7b OTU domain containing 7B [ Mus musculus (house mouse) ]

    Gene ID: 229603, updated on 4-Jan-2025

    Summary

    Official Symbol
    Otud7bprovided by MGI
    Official Full Name
    OTU domain containing 7Bprovided by MGI
    Primary source
    MGI:MGI:2654703
    See related
    Ensembl:ENSMUSG00000038495 AllianceGenome:MGI:2654703
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Za20d1; CEZANNE; Trabid2; 2900060B22Rik; 4930463P07Rik
    Summary
    Enables K63-linked polyubiquitin modification-dependent protein binding activity and cysteine-type deubiquitinase activity. Involved in several processes, including negative regulation of canonical NF-kappaB signal transduction; negative regulation of transcription by RNA polymerase II; and protein K48-linked deubiquitination. Acts upstream of or within in utero embryonic development and protein deubiquitination. Located in cytoplasm. Orthologous to human OTUD7B (OTU deubiquitinase 7B). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Ubiquitous expression in testis adult (RPKM 8.7), lung adult (RPKM 6.7) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Otud7b in Genome Data Viewer
    Location:
    3 F2.1; 3 41.65 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (96011759..96068446)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (96104504..96161129)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene vacuolar protein sorting 45 Neighboring gene STARR-positive B cell enhancer ABC_E2674 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:95861936-95862045 Neighboring gene predicted gene, 54210 Neighboring gene STARR-positive B cell enhancer ABC_E6079 Neighboring gene predicted gene, 30044 Neighboring gene STARR-positive B cell enhancer ABC_E4561 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:95976180-95976363 Neighboring gene STARR-seq mESC enhancer starr_08407 Neighboring gene myotubularin related protein 11 Neighboring gene predicted gene, 22027 Neighboring gene splicing factor 3b, subunit 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (5) 
    • Targeted (4)  1 citation

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in adaptive immune response  
    acts_upstream_of_or_within in utero embryonic development PubMed 
    involved_in mucosal immune response PubMed 
    involved_in negative regulation of TORC1 signaling  
    involved_in negative regulation of canonical NF-kappaB signal transduction  
    involved_in negative regulation of canonical NF-kappaB signal transduction PubMed 
    involved_in negative regulation of canonical NF-kappaB signal transduction  
    involved_in negative regulation of interleukin-8 production  
    involved_in negative regulation of interleukin-8 production  
    involved_in negative regulation of protein localization to nucleus  
    involved_in negative regulation of protein localization to nucleus  
    involved_in negative regulation of transcription by RNA polymerase II PubMed 
    involved_in negative regulation of transcription by RNA polymerase II  
    involved_in positive regulation of TORC2 signaling  
    involved_in protein K11-linked deubiquitination  
    involved_in protein K11-linked deubiquitination  
    involved_in protein K48-linked deubiquitination PubMed 
    involved_in protein K48-linked deubiquitination  
    involved_in protein K63-linked deubiquitination  
    involved_in protein K63-linked deubiquitination  
    acts_upstream_of_or_within protein deubiquitination PubMed 
    involved_in protein deubiquitination involved in ubiquitin-dependent protein catabolic process  
    involved_in proteolysis  
    Component Evidence Code Pubs
    is_active_in cytoplasm  
    located_in cytoplasm PubMed 
    located_in cytoplasm  
    is_active_in nucleus  
    located_in nucleus  
    located_in nucleus  

    General protein information

    Preferred Names
    OTU domain-containing protein 7B
    Names
    TRAF binding domain containing 2
    cellular zinc finger anti-NF-kappa-B protein
    zinc finger A20 domain-containing protein 1
    zinc finger protein Cezanne
    zinc finger, A20 domain containing 1
    NP_001020784.1
    NP_001020785.1
    XP_006501448.1
    XP_006501449.1
    XP_006501452.1
    XP_017175035.1
    XP_017175037.1
    XP_030108444.1
    XP_030108445.1
    XP_036018961.1
    XP_036018962.1
    XP_036018963.1
    XP_036018964.1
    XP_036018965.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001025613.1NP_001020784.1  OTU domain-containing protein 7B

      See identical proteins and their annotated locations for NP_001020784.1

      Status: VALIDATED

      Source sequence(s)
      AC092094, AK044701, BB596613
      Consensus CDS
      CCDS17629.1
      UniProtKB/Swiss-Prot
      B2RUR8, Q8CFS0
      Related
      ENSMUSP00000088291.3, ENSMUST00000090785.9
      Conserved Domains (3) summary
      cd14347
      Location:446
      UBA_Cezanne_like; UBA-like domain found in OTU domain-containing proteins OTU7A, OTU7B and similar proteins
      pfam01754
      Location:798820
      zf-A20; A20-like zinc finger
      cl19932
      Location:189359
      OTU; OTU-like cysteine protease
    2. NM_001025614.1NP_001020785.1  OTU domain-containing protein 7B

      See identical proteins and their annotated locations for NP_001020785.1

      Status: VALIDATED

      Source sequence(s)
      AC092094, AK044701, BB596613
      Consensus CDS
      CCDS17629.1
      UniProtKB/Swiss-Prot
      B2RUR8, Q8CFS0
      Related
      ENSMUSP00000046413.6, ENSMUST00000035519.12
      Conserved Domains (3) summary
      cd14347
      Location:446
      UBA_Cezanne_like; UBA-like domain found in OTU domain-containing proteins OTU7A, OTU7B and similar proteins
      pfam01754
      Location:798820
      zf-A20; A20-like zinc finger
      cl19932
      Location:189359
      OTU; OTU-like cysteine protease

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      96011759..96068446
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030252585.2XP_030108445.1  OTU domain-containing protein 7B isoform X2

      Conserved Domains (2) summary
      pfam01754
      Location:706728
      zf-A20; A20-like zinc finger
      cl19932
      Location:97267
      OTU; OTU-like cysteine protease
    2. XM_036163070.1XP_036018963.1  OTU domain-containing protein 7B isoform X1

      UniProtKB/Swiss-Prot
      B2RUR8, Q8CFS0
      Conserved Domains (3) summary
      cd14347
      Location:446
      UBA_Cezanne_like; UBA-like domain found in OTU domain-containing proteins OTU7A, OTU7B and similar proteins
      pfam01754
      Location:798820
      zf-A20; A20-like zinc finger
      cl19932
      Location:189359
      OTU; OTU-like cysteine protease
    3. XM_030252584.2XP_030108444.1  OTU domain-containing protein 7B isoform X2

      Conserved Domains (2) summary
      pfam01754
      Location:706728
      zf-A20; A20-like zinc finger
      cl19932
      Location:97267
      OTU; OTU-like cysteine protease
    4. XM_017319548.3XP_017175037.1  OTU domain-containing protein 7B isoform X2

      Conserved Domains (2) summary
      pfam01754
      Location:706728
      zf-A20; A20-like zinc finger
      cl19932
      Location:97267
      OTU; OTU-like cysteine protease
    5. XM_036163068.1XP_036018961.1  OTU domain-containing protein 7B isoform X1

      UniProtKB/Swiss-Prot
      B2RUR8, Q8CFS0
      Conserved Domains (3) summary
      cd14347
      Location:446
      UBA_Cezanne_like; UBA-like domain found in OTU domain-containing proteins OTU7A, OTU7B and similar proteins
      pfam01754
      Location:798820
      zf-A20; A20-like zinc finger
      cl19932
      Location:189359
      OTU; OTU-like cysteine protease
    6. XM_006501385.4XP_006501448.1  OTU domain-containing protein 7B isoform X1

      See identical proteins and their annotated locations for XP_006501448.1

      UniProtKB/Swiss-Prot
      B2RUR8, Q8CFS0
      Conserved Domains (3) summary
      cd14347
      Location:446
      UBA_Cezanne_like; UBA-like domain found in OTU domain-containing proteins OTU7A, OTU7B and similar proteins
      pfam01754
      Location:798820
      zf-A20; A20-like zinc finger
      cl19932
      Location:189359
      OTU; OTU-like cysteine protease
    7. XM_036163069.1XP_036018962.1  OTU domain-containing protein 7B isoform X2

      Conserved Domains (2) summary
      pfam01754
      Location:706728
      zf-A20; A20-like zinc finger
      cl19932
      Location:97267
      OTU; OTU-like cysteine protease
    8. XM_006501389.4XP_006501452.1  OTU domain-containing protein 7B isoform X1

      See identical proteins and their annotated locations for XP_006501452.1

      UniProtKB/Swiss-Prot
      B2RUR8, Q8CFS0
      Conserved Domains (3) summary
      cd14347
      Location:446
      UBA_Cezanne_like; UBA-like domain found in OTU domain-containing proteins OTU7A, OTU7B and similar proteins
      pfam01754
      Location:798820
      zf-A20; A20-like zinc finger
      cl19932
      Location:189359
      OTU; OTU-like cysteine protease
    9. XM_006501386.3XP_006501449.1  OTU domain-containing protein 7B isoform X1

      See identical proteins and their annotated locations for XP_006501449.1

      UniProtKB/Swiss-Prot
      B2RUR8, Q8CFS0
      Related
      ENSMUSP00000096449.3, ENSMUST00000098849.3
      Conserved Domains (3) summary
      cd14347
      Location:446
      UBA_Cezanne_like; UBA-like domain found in OTU domain-containing proteins OTU7A, OTU7B and similar proteins
      pfam01754
      Location:798820
      zf-A20; A20-like zinc finger
      cl19932
      Location:189359
      OTU; OTU-like cysteine protease
    10. XM_036163071.1XP_036018964.1  OTU domain-containing protein 7B isoform X2

      Conserved Domains (2) summary
      pfam01754
      Location:706728
      zf-A20; A20-like zinc finger
      cl19932
      Location:97267
      OTU; OTU-like cysteine protease
    11. XM_036163072.1XP_036018965.1  OTU domain-containing protein 7B isoform X2

      Conserved Domains (2) summary
      pfam01754
      Location:706728
      zf-A20; A20-like zinc finger
      cl19932
      Location:97267
      OTU; OTU-like cysteine protease
    12. XM_017319546.1XP_017175035.1  OTU domain-containing protein 7B isoform X1

      UniProtKB/Swiss-Prot
      B2RUR8, Q8CFS0
      Conserved Domains (3) summary
      cd14347
      Location:446
      UBA_Cezanne_like; UBA-like domain found in OTU domain-containing proteins OTU7A, OTU7B and similar proteins
      pfam01754
      Location:798820
      zf-A20; A20-like zinc finger
      cl19932
      Location:189359
      OTU; OTU-like cysteine protease
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