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    Fancm Fanconi anemia, complementation group M [ Mus musculus (house mouse) ]

    Gene ID: 104806, updated on 4-Jan-2025

    Summary

    Official Symbol
    Fancmprovided by MGI
    Official Full Name
    Fanconi anemia, complementation group Mprovided by MGI
    Primary source
    MGI:MGI:2442306
    See related
    Ensembl:ENSMUSG00000055884 AllianceGenome:MGI:2442306
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    D12Ertd364e; C730036B14Rik
    Summary
    Predicted to enable DNA helicase activity; chromatin binding activity; and four-way junction DNA binding activity. Predicted to be involved in DNA metabolic process and positive regulation of protein monoubiquitination. Predicted to be located in chromatin and nucleoplasm. Predicted to be part of FANCM-MHF complex and Fanconi anaemia nuclear complex. Is expressed in lung; mandible; and temporal bone petrous part. Human ortholog(s) of this gene implicated in primary ovarian insufficiency 15 and spermatogenic failure 28. Orthologous to human FANCM (FA complementation group M). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 3.1), CNS E14 (RPKM 2.0) and 25 other tissues See more
    Orthologs
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    Genomic context

    See Fancm in Genome Data Viewer
    Location:
    12 C1; 12 27.21 cM
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (65120884..65178616)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (65074110..65131842)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene pre-mRNA processing factor 39 Neighboring gene predicted gene, 25970 Neighboring gene STARR-positive B cell enhancer ABC_E5331 Neighboring gene STARR-positive B cell enhancer ABC_E4026 Neighboring gene FK506 binding protein 3 Neighboring gene STARR-seq mESC enhancer starr_32318 Neighboring gene MIS18 binding protein 1 Neighboring gene STARR-seq mESC enhancer starr_32320 Neighboring gene predicted gene, 31063

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 3'-5' DNA helicase activity  
    enables 3'-5' DNA helicase activity  
    enables ATP binding  
    enables ATP hydrolysis activity  
    enables ATP-dependent H2AZ histone chaperone activity  
    enables ATP-dependent H3-H4 histone complex chaperone activity  
    enables DNA binding  
    enables DNA clamp loader activity  
    enables RNA helicase activity  
    enables chromatin binding  
    enables chromatin binding  
    enables chromatin extrusion motor activity  
    enables cohesin loader activity  
    enables four-way junction DNA binding  
    enables four-way junction helicase activity  
    enables nuclease activity  
    Process Evidence Code Pubs
    involved_in DNA duplex unwinding  
    involved_in chromatin looping  
    involved_in chromatin remodeling  
    involved_in double-strand break repair via synthesis-dependent strand annealing  
    involved_in interstrand cross-link repair  
    involved_in interstrand cross-link repair  
    involved_in interstrand cross-link repair  
    involved_in positive regulation of protein monoubiquitination  
    involved_in positive regulation of protein monoubiquitination  
    involved_in replication fork processing  
    involved_in replication fork processing  
    involved_in resolution of meiotic recombination intermediates  
    involved_in resolution of meiotic recombination intermediates  
    Component Evidence Code Pubs
    part_of FANCM-MHF complex  
    part_of FANCM-MHF complex  
    part_of Fanconi anaemia nuclear complex  
    part_of Fanconi anaemia nuclear complex  
    located_in chromatin  
    located_in chromatin  
    located_in nucleoplasm  
    located_in nucleoplasm  

    General protein information

    Preferred Names
    Fanconi anemia group M protein homolog
    Names
    ATP-dependent RNA helicase FANCM
    NP_001351376.1
    NP_849243.2
    XP_006515403.1
    XP_006515404.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001364447.1NP_001351376.1  Fanconi anemia group M protein homolog isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC159621, AK173211
      Conserved Domains (2) summary
      pfam16783
      Location:128
      FANCM-MHF_bd; FANCM to MHF binding domain
      cl27383
      Location:10231258
      ERCC4; ERCC4 domain
    2. NM_178912.4NP_849243.2  Fanconi anemia group M protein homolog isoform 1

      See identical proteins and their annotated locations for NP_849243.2

      Status: VALIDATED

      Source sequence(s)
      AC159621, AK050306, AK050832, AK085388, AK173211
      Consensus CDS
      CCDS25941.1
      UniProtKB/Swiss-Prot
      Q69ZF5, Q8BGE5, Q8BKB7, Q8BUA8
      UniProtKB/TrEMBL
      B2RX10
      Related
      ENSMUSP00000054797.5, ENSMUST00000058889.5
      Conserved Domains (7) summary
      COG1111
      Location:71610
      MPH1; ERCC4-related helicase [Replication, recombination and repair]
      COG1948
      Location:17641999
      MUS81; ERCC4-type nuclease [Replication, recombination and repair]
      cd00046
      Location:94236
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      cd12091
      Location:287401
      FANCM_ID; Insert domain of FANCM and related proteins
      pfam00271
      Location:457564
      Helicase_C; Helicase conserved C-terminal domain
      pfam02732
      Location:17831909
      ERCC4; ERCC4 domain
      pfam16783
      Location:657769
      FANCM-MHF_bd; FANCM to MHF binding domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      65120884..65178616
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006515341.4XP_006515404.1  Fanconi anemia group M protein homolog isoform X2

      UniProtKB/TrEMBL
      B2RX10
      Conserved Domains (4) summary
      COG1111
      Location:71529
      MPH1; ERCC4-related helicase [Replication, recombination and repair]
      COG1948
      Location:16951930
      MUS81; ERCC4-type nuclease [Replication, recombination and repair]
      cd18033
      Location:77258
      DEXDc_FANCM; DEAH-box helicase domain of FANCM
      pfam16783
      Location:588700
      FANCM-MHF_bd; FANCM to MHF binding domain
    2. XM_006515340.5XP_006515403.1  Fanconi anemia group M protein homolog isoform X1

      UniProtKB/TrEMBL
      B2RX10
      Conserved Domains (3) summary
      COG1111
      Location:71610
      MPH1; ERCC4-related helicase [Replication, recombination and repair]
      COG1948
      Location:17201955
      MUS81; ERCC4-type nuclease [Replication, recombination and repair]
      pfam16783
      Location:657769
      FANCM-MHF_bd; FANCM to MHF binding domain
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