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    AKAP4 A-kinase anchoring protein 4 [ Homo sapiens (human) ]

    Gene ID: 8852, updated on 4-Jan-2025

    Summary

    Official Symbol
    AKAP4provided by HGNC
    Official Full Name
    A-kinase anchoring protein 4provided by HGNC
    Primary source
    HGNC:HGNC:374
    See related
    Ensembl:ENSG00000147081 MIM:300185; AllianceGenome:HGNC:374
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HI; p82; CT99; FSC1; PRKA4; AKAP-4; AKAP82; AKAP 82; hAKAP82
    Summary
    The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein is localized to the sperm flagellum and may be involved in the regulation of sperm motility. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
    Expression
    Restricted expression toward testis (RPKM 101.7) See more
    Orthologs
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    Genomic context

    See AKAP4 in Genome Data Viewer
    Location:
    Xp11.22
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (50190777..50201007, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (49508429..49518665, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (49955420..49965658, complement)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene chloride voltage-gated channel 5 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chrX:49809130-49809715 Neighboring gene microRNA 502 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chrX:49854497-49855696 Neighboring gene peptide YY 3 (pseudogene) Neighboring gene cyclin B3 Neighboring gene diacylglycerol kinase kappa Neighboring gene Sharpr-MPRA regulatory region 2913 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:50212987-50213784

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding PubMed 
    enables protein kinase A binding  
    enables protein kinase A binding  
    Process Evidence Code Pubs
    involved_in cell surface receptor protein serine/threonine kinase signaling pathway  
    involved_in establishment of localization in cell  
    involved_in establishment of protein localization  
    involved_in flagellated sperm motility PubMed 
    involved_in protein localization  
    involved_in signal transduction PubMed 
    involved_in single fertilization PubMed 
    involved_in sperm flagellum assembly  
    involved_in spermatogenesis  
    Component Evidence Code Pubs
    located_in Z disc  
    part_of cAMP-dependent protein kinase complex PubMed 
    is_active_in cytoplasm  
    located_in cytoskeleton PubMed 
    located_in motile cilium PubMed 
    located_in nucleus PubMed 
    located_in perinuclear region of cytoplasm  
    located_in sperm end piece PubMed 
    is_active_in sperm fibrous sheath  
    is_active_in sperm fibrous sheath PubMed 
    is_active_in sperm flagellum PubMed 
    located_in sperm head-tail coupling apparatus PubMed 
    located_in sperm midpiece PubMed 
    is_active_in sperm principal piece  
    located_in sperm principal piece PubMed 

    General protein information

    Preferred Names
    A-kinase anchor protein 4
    Names
    A kinase (PRKA) anchor protein 4
    A-kinase anchor protein 82 kDa
    cancer/testis antigen 99
    epididymis secretory sperm binding protein
    major sperm fibrous sheath protein
    protein kinase A anchoring protein 4
    testis-specific gene HI

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012552.2 RefSeqGene

      Range
      5007..15237
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_003886.3NP_003877.2  A-kinase anchor protein 4 isoform 1

      See identical proteins and their annotated locations for NP_003877.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) includes an alternate 5' exon and encodes a longer isoform, as compared to variant 2.
      Source sequence(s)
      AC235789
      Consensus CDS
      CCDS14329.1
      UniProtKB/Swiss-Prot
      A0AV85, O60904, O95246, Q5JQC9, Q5JQD1, Q5JQD2, Q5JQD3
      UniProtKB/TrEMBL
      A0A384MQY7, A8K8U8
      Related
      ENSP00000351327.2, ENST00000358526.7
      Conserved Domains (1) summary
      smart00807
      Location:14854
      AKAP_110; A-kinase anchor protein 110 kDa
    2. NM_139289.2NP_647450.1  A-kinase anchor protein 4 isoform 2

      See identical proteins and their annotated locations for NP_647450.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) includes an alternate 5' exon, which lacks an ATG start codon, as compared to variant 1. This variant uses a downstream in-frame start codon, and thus encodes a shorter isoform.
      Source sequence(s)
      AC235789
      Consensus CDS
      CCDS14330.1
      UniProtKB/TrEMBL
      A8K8U8
      Related
      ENSP00000365232.3, ENST00000376064.7
      Conserved Domains (1) summary
      smart00807
      Location:5845
      AKAP_110; A-kinase anchor protein 110 kDa

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      50190777..50201007 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      49508429..49518665 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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