ZNF704 zinc finger protein 704 [Homo sapiens (human)] - Gene

Summary

Official Symbol: ZNF704provided by HGNC
Official Full Name: zinc finger protein 704provided by HGNC
Primary source: HGNC:HGNC:32291
See related: Ensembl:ENSG00000164684 AllianceGenome:HGNC:32291
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: Gig1
Summary: Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in endometrium (RPKM 8.6), ovary (RPKM 8.1) and 24 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 8q21.13

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	8	NC_000008.11 (80628451..80884419, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	8	NC_060932.1 (81060029..81315991, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	8	NC_000008.10 (81540686..81787016, complement)

Chromosome 8 - NC_000008.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Tissue-specific circular RNA induction during human fetal development
Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
BioProject: PRJNA270632
Publication: PMID 26076956
Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Circular RNA HSDL2 promotes breast cancer progression via miR-7978 ZNF704 axis and regulating hippo signaling pathway.
Title: Circular RNA HSDL2 promotes breast cancer progression via miR-7978 ZNF704 axis and regulating hippo signaling pathway.
Circadian Rhythm Is Disrupted by ZNF704 in Breast Carcinogenesis.
Title: Circadian Rhythm Is Disrupted by ZNF704 in Breast Carcinogenesis.
tumor marker zinc finger protein 704 as part of a four gene transcript score has prognostic value for metastatic-lethal progression in men treated for localized prostate cancer
Title: A four-gene transcript score to predict metastatic-lethal progression in men treated for localized prostate cancer: Development and validation studies.

Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

STS-N55108 (e-PCR)
- UniSTS:25113

D8S1395E (e-PCR)
- UniSTS:39216

STS-N33187 (e-PCR)
- UniSTS:68666

RH68638 (e-PCR)
- UniSTS:3931

D8S1095 (e-PCR)
- UniSTS:52328

D8S1408E (e-PCR)
- UniSTS:151201

SHGC-85851 (e-PCR)
- UniSTS:103848

RH122469 (e-PCR)
- UniSTS:135341

SHGC-154425 (e-PCR)
- UniSTS:178096

SHGC-53169 (e-PCR)
- UniSTS:51387

SHGC-142021 (e-PCR)
- UniSTS:171200

RH122498 (e-PCR)
- UniSTS:135371

RH12788 (e-PCR)
- UniSTS:63463

RH18330 (e-PCR)
- UniSTS:27124

RH45668 (e-PCR)
- UniSTS:54520

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific double-stranded DNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: zinc finger protein 704

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.