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    BEX4 brain expressed X-linked 4 [ Homo sapiens (human) ]

    Gene ID: 56271, updated on 10-Dec-2024

    Summary

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    Official Symbol
    BEX4provided by HGNC
    Official Full Name
    brain expressed X-linked 4provided by HGNC
    Primary source
    HGNC:HGNC:25475
    See related
    Ensembl:ENSG00000102409 MIM:300692; AllianceGenome:HGNC:25475
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    BEXL1
    Summary
    This gene is a member of the brain expressed X-linked gene family. The proteins encoded by some of the other members of this family act as transcription elongation factors which allow RNA polymerase II to escape pausing during elongation. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Aug 2011]
    Expression
    Ubiquitous expression in brain (RPKM 111.7), thyroid (RPKM 67.9) and 23 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See BEX4 in Genome Data Viewer
    Location:
    Xq22.1
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (103215092..103217246)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (101662085..101664239)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (102470020..102472174)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene zinc finger protein 770 pseudogene Neighboring gene nuclear RNA export factor 3 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:102358711-102359380 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chrX:102438681-102439434 Neighboring gene CRISPRi-validated cis-regulatory element chrX.1663 Neighboring gene ribosomal protein SA pseudogene 59 Neighboring gene CRISPRi-validated cis-regulatory element chrX.1665 Neighboring gene CRISPRi-validated cis-regulatory element chrX.1666 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29816 Neighboring gene guanosine monophosphate reductase pseudogene Neighboring gene transcription elongation factor A like 8

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Aberrant brain-expressed X-linked 4 (BEX4) expression is a novel prognostic biomarker in gastric cancer. Zhu C, et al. Medicine (Baltimore), 2020 Nov 20. PMID 33217815, Free PMC Article
    2. Decreased brain-expressed X-linked 4 (BEX4) expression promotes growth of oral squamous cell carcinoma. Gao W, et al. J Exp Clin Cancer Res, 2016 Jun 13. PMID 27297407, Free PMC Article
    3. Oncogenic potential of BEX4 is conferred by Polo-like kinase 1-mediated phosphorylation. Lee JK, et al. Exp Mol Med, 2018 Oct 22. PMID 30367032, Free PMC Article
    4. mTOR up-regulation of BEX4 promotes lung adenocarcinoma cell proliferation by potentiating OCT4. Zhao Z, et al. Biochem Biophys Res Commun, 2018 Jun 2. PMID 29660335
    5. Oncogenic microtubule hyperacetylation through BEX4-mediated sirtuin 2 inhibition. Lee JK, et al. Cell Death Dis, 2016 Aug 11. PMID 27512957, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Aberrant brain-expressed X-linked 4 (BEX4) expression is a novel prognostic biomarker in gastric cancer.
      Title: Aberrant brain-expressed X-linked 4 (BEX4) expression is a novel prognostic biomarker in gastric cancer.
    2. these results suggest that the oncogenicity of BEX4 is conferred by PLK1-mediated phosphorylation, and thus, the BEX4-PLK1 interaction is a novel oncogenic signal that enables the acquisition of chromosomal aneuploidy.
      Title: Oncogenic potential of BEX4 is conferred by Polo-like kinase 1-mediated phosphorylation.
    3. BEX4 positively regulated the expression of OCT4, silencing of which reduced the proliferation of A549 and H1975cells with over-expressed BEX4.
      Title: mTOR up-regulation of BEX4 promotes lung adenocarcinoma cell proliferation by potentiating OCT4.
    4. Study provides evidence that BEX4 functions as tumor suppressor by inhibiting proliferation and growth of oral squamous cell carcinoma (OSCC). Decreased BEX4 contributes to the increased proliferative propensity of OSCC.
      Title: Decreased brain-expressed X-linked 4 (BEX4) expression promotes growth of oral squamous cell carcinoma.
    5. BEX4 overexpression causes an imbalance between TUB acetylation and deacetylation by SIRT2 inhibition and induces oncogenic aneuploidy transformation.
      Title: Oncogenic microtubule hyperacetylation through BEX4-mediated sirtuin 2 inhibition.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ10097

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables alpha-tubulin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables histone deacetylase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular function inhibitor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chromosome segregation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of protein ubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of tubulin deacetylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in microtubule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in spindle pole IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    protein BEX4
    Names
    BEX family member 4
    BEX1-like protein 1
    brain expressed X-linked-like 1
    nerve growth factor receptor-associated protein 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_021339.1 RefSeqGene

      Range
      5017..7155
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001080425.4 → NP_001073894.1  protein BEX4

      See identical proteins and their annotated locations for NP_001073894.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) contains an alternate non-coding exon in the 5' UTR. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AI199874, AL035494, AV726729, BC015794, BC068069
      Consensus CDS
      CCDS35355.1
      UniProtKB/Swiss-Prot
      Q9NWD9
      Related
      ENSP00000361780.5, ENST00000372695.6
      Conserved Domains (1) summary
      pfam04538
      Location:15 → 116
      BEX; Brain expressed X-linked like family

    2. NM_001127688.2 → NP_001121160.1  protein BEX4

      See identical proteins and their annotated locations for NP_001121160.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the shorter transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AI199874, AL035494, AL544124, AV726729
      Consensus CDS
      CCDS35355.1
      UniProtKB/Swiss-Prot
      Q9NWD9
      Related
      ENSP00000361776.3, ENST00000372691.3
      Conserved Domains (1) summary
      pfam04538
      Location:15 → 116
      BEX; Brain expressed X-linked like family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      103215092..103217246
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      101662085..101664239
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9NWD9.1 GenPept UniProtKB/Swiss-Prot:Q9NWD9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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