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    SNHG11 small nucleolar RNA host gene 11 [ Homo sapiens (human) ]

    Gene ID: 128439, updated on 10-Dec-2024

    Summary

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    Official Symbol
    SNHG11provided by HGNC
    Official Full Name
    small nucleolar RNA host gene 11provided by HGNC
    Primary source
    HGNC:HGNC:25046
    See related
    Ensembl:ENSG00000174365 MIM:619494; AllianceGenome:HGNC:25046
    Gene type
    ncRNA
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    C20orf198; LINC00101; NCRNA00101
    Summary
    This gene is a member of the non-protein-coding multiple snoRNA host gene family. Two snoRNAs are derived from the introns of this host gene. Although many alternative splice variants have been observed, the gene is thought to have no protein-coding potential. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in testis (RPKM 6.8), prostate (RPKM 5.3) and 25 other tissues See more
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    Genomic context

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    See SNHG11 in Genome Data Viewer
    Location:
    20q11.23
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (38446654..38450921)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (40174250..40178518)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (37075297..37079564)

    Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124904958 Neighboring gene small nucleolar RNA host gene 17 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17857 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17858 Neighboring gene small nucleolar RNA SNORA71 Neighboring gene small nucleolar RNA, H/ACA box 71D Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17859 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:37076132-37076686 Neighboring gene small nucleolar RNA, H/ACA box 71E Neighboring gene small nucleolar RNA, H/ACA box 60 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17860 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12899 Neighboring gene Ral GTPase activating protein non-catalytic subunit beta Neighboring gene microRNA 548o-2 Neighboring gene ribosomal protein S3 pseudogene 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. The function of long non-coding RNA SNHG11 and its working mechanism in triple-negative breast cancer. Al-Hazani TMI, et al. Pathol Res Pract, 2023 Aug. PMID 37320865
    2. SNHG11: A New Budding Star in Tumors and Inflammatory Diseases. Wu Y. Mini Rev Med Chem, 2023. PMID 37165588
    3. Prostate cancer risk SNP rs10993994 is a trans-eQTL for SNHG11 mediated through MSMB. Bicak M, et al. Hum Mol Genet, 2020 Jun 27. PMID 32065238, Free PMC Article
    4. LncRNA SNHG11 accelerates the progression of lung adenocarcinoma via activating Notch pathways. Deng Y, et al. Pathol Res Pract, 2022 Jun. PMID 35487027
    5. LncRNA SNHG11 enhances bevacizumab resistance in colorectal cancer by mediating miR-1207-5p/ABCC1 axis. Huang W, et al. Anticancer Drugs, 2022 Jul 1. PMID 35324517

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The lncRNA Snhg11, a new candidate contributing to neurogenesis, plasticity, and memory deficits in Down syndrome.
      Title: The lncRNA Snhg11, a new candidate contributing to neurogenesis, plasticity, and memory deficits in Down syndrome.
    2. [LncRNA SNHG11 promotes malignant progression of colorectal cancer cells through the PI3K/Akt/mTOR signaling pathway].
      Title: [LncRNA SNHG11 promotes malignant progression of colorectal cancer cells through the PI3K/Akt/mTOR signaling pathway].
    3. SNHG11: A New Budding Star in Tumors and Inflammatory Diseases.
      Title: SNHG11: A New Budding Star in Tumors and Inflammatory Diseases.
    4. The function of long non-coding RNA SNHG11 and its working mechanism in triple-negative breast cancer.
      Title: The function of long non-coding RNA SNHG11 and its working mechanism in triple-negative breast cancer.
    5. Long non-coding RNA SNHG11 regulates the Wnt/beta-catenin signaling pathway through rho/ROCK in trabecular meshwork cells.
      Title: Long non-coding RNA SNHG11 regulates the Wnt/β-catenin signaling pathway through rho/ROCK in trabecular meshwork cells.
    6. lncRNA SNHG11 promotes the development of colorectal cancer by mediating miR-339-3p/SHOX2.
      Title: lncRNA SNHG11 promotes the development of colorectal cancer by mediating miR-339-3p/SHOX2.
    7. LncRNA SNHG11 accelerates the progression of lung adenocarcinoma via activating Notch pathways.
      Title: LncRNA SNHG11 accelerates the progression of lung adenocarcinoma via activating Notch pathways.
    8. LncRNA SNHG11 enhances bevacizumab resistance in colorectal cancer by mediating miR-1207-5p/ABCC1 axis.
      Title: LncRNA SNHG11 enhances bevacizumab resistance in colorectal cancer by mediating miR-1207-5p/ABCC1 axis.
    9. Prognostic Value of Long Noncoding RNA SNHG11 in Patients with Prostate Cancer.
      Title: Prognostic Value of Long Noncoding RNA SNHG11 in Patients with Prostate Cancer.
    10. Exosome-mediated lncRNA SNHG11 regulates angiogenesis in pancreatic carcinoma through miR-324-3p/VEGFA axis.
      Title: Exosome-mediated lncRNA SNHG11 regulates angiogenesis in pancreatic carcinoma through miR-324-3p/VEGFA axis.
    Submit: New GeneRIF Correction See all GeneRIFs (20)

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Other Names

    • long intergenic non-protein coding RNA 101
    • small nucleolar RNA host gene (non-protein coding) 11
    • small nucleolar RNA host gene 11 (non-protein coding)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_003239.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AF454939, AF497716, AK055434
      Related
      ENST00000656815.2

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

      Range
      38446654..38450921
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060944.1 Alternate T2T-CHM13v2.0

      Range
      40174250..40178518
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_139016.2: Suppressed sequence

      Description
      NM_139016.2: This RefSeq was permanently suppressed because it is now thought that this gene does not encode a protein.
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

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