OPRM1 opioid receptor mu 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: OPRM1provided by HGNC
Official Full Name: opioid receptor mu 1provided by HGNC
Primary source: HGNC:HGNC:8156
See related: Ensembl:ENSG00000112038 MIM:600018; AllianceGenome:HGNC:8156
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: MOP; MOR; LMOR; MOR1; OPRM; M-OR-1
Summary: This gene encodes one of at least three opioid receptors in humans; the mu opioid receptor (MOR). The MOR is the principal target of endogenous opioid peptides and opioid analgesic agents such as beta-endorphin and enkephalins. The MOR also has an important role in dependence to other drugs of abuse, such as nicotine, cocaine, and alcohol via its modulation of the dopamine system. The NM_001008503.2:c.118A>G allele has been associated with opioid and alcohol addiction and variations in pain sensitivity but evidence for it having a causal role is conflicting. Multiple transcript variants encoding different isoforms have been found for this gene. Though the canonical MOR belongs to the superfamily of 7-transmembrane-spanning G-protein-coupled receptors some isoforms of this gene have only 6 transmembrane domains. [provided by RefSeq, Oct 2013]
Expression: Low expression observed in reference dataset See more
Orthologs: mouse all
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Genomic context

Location:: 6q25.2

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	6	NC_000006.12 (154010496..154246867)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	6	NC_060930.1 (155212511..155448859)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	6	NC_000006.11 (154331631..154568001)

Chromosome 6 - NC_000006.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Delta opioid receptor expression correlates to skin ageing and melanin expression in Asian women.
Title: Delta opioid receptor expression correlates to skin ageing and melanin expression in Asian women.
Association of OPRM1 rs1799971, HTR1B rs6296 and COMT rs4680 polymorphisms with clinical phenotype among women with fibromyalgia.
Title: Association of OPRM1 rs1799971, HTR1B rs6296 and COMT rs4680 polymorphisms with clinical phenotype among women with fibromyalgia.
Epigenetic and sex differences in opioid use disorder in chronic pain: A real-world study linked with OPRM1 DNA methylation.
Title: Epigenetic and sex differences in opioid use disorder in chronic pain: A real-world study linked with OPRM1 DNA methylation.
OPRM1 rs2075572 has potential to affect plasma buprenorphine level in opioid users, but not OPRM1 rs562859.
Title: OPRM1 rs2075572 has potential to affect plasma buprenorphine level in opioid users, but not OPRM1 rs562859.
Effects of functional polymorphisms of opioid receptor mu 1 and catechol-O-methyltransferase on the neural processing of pain.
Title: Effects of functional polymorphisms of opioid receptor mu 1 and catechol-O-methyltransferase on the neural processing of pain.
Variation in the mu-opioid receptor gene (OPRM1) moderates the influence of maternal sensitivity on child attachment.
Title: Variation in the mu-opioid receptor gene (OPRM1) moderates the influence of maternal sensitivity on child attachment.
Accumbal mu-opioid receptors and salt taste-elicited hedonic responses in a rodent model of prenatal adversity, and their correlates using human functional genomics.
Title: Accumbal μ-opioid receptors and salt taste-elicited hedonic responses in a rodent model of prenatal adversity, and their correlates using human functional genomics.
OPRM1 Gene Polymorphism in Women with Alcohol Use Disorder.
Title: OPRM1 Gene Polymorphism in Women with Alcohol Use Disorder.
A novel tetra-primer ARMS-PCR for genotyping of the OPRM1 gene rs1799971 variant associated with opioid use disorders.
Title: A novel tetra-primer ARMS-PCR for genotyping of the OPRM1 gene rs1799971 variant associated with opioid use disorders.
Polymorphisms in the A118G SNP of the OPRM1 gene produce different experiences of opioids: A human laboratory phenotype-genotype assessment.
Title: Polymorphisms in the A118G SNP of the OPRM1 gene produce different experiences of opioids: A human laboratory phenotype-genotype assessment.

Submit: New GeneRIF Correction See all GeneRIFs (497)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome-wide association study identifies multiple susceptibility loci for chronic lymphocytic leukemia. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	Cyclic d-Phe-Cys-Tyr-d-Trp-Arg-Thr-Pen-Thr-NH2 (CTAP), mu-opioid receptor-selective antagonist, significantly delay the febrile response induced by HIV-1 gp120, suggesting that mu-opioid receptors can regulate gp120-induced fever	PubMed
	env	HIV-1 gp120 induces desensitization of a mu-opioid-receptor-mediated response in brain periaqueductal gray neurons	PubMed
	env	HIV-1 gp120 upregulates mu opioid receptor (MOR) expression in TPA-differentiated HL-60 cells; treatment with TNF-alpha neutralizing antibody as well as anti-TNF-alpha receptor type II (TNFR-II) antibody, inhibits gp120-induced upregulation of MOR	PubMed
	env	HIV-1 gp120 upregulates mu opiate receptor expression in human vascular endothelium; in contrast, morphine decreases mu opioid receptor expression	PubMed
Tat	tat	The synergistic upregulation of CXCL10 expression by HIV-1 Tat and IFN-gamma is inhibited by mu-opioid receptor (MOR) antagonist beta-funaltrexamine in human astrocytes	PubMed
	tat	Morphine treatment in the presence of Tat significantly increases intracellular expression of opioid receptors (mu, delta, and kappa) and prevents morphine-induced cell surface opioid receptor down-regulation in microglia	PubMed

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

G62475 (e-PCR)
- UniSTS:139533

D6S1836 (e-PCR)
- UniSTS:28223

NoName (e-PCR)
- UniSTS:486727

D6S2185 (e-PCR)
- UniSTS:8525

NoName (e-PCR)
- UniSTS:495199

NoName (e-PCR)
- UniSTS:482168

WI-17899 (e-PCR)
- UniSTS:7310

OPRM1 (e-PCR)
- UniSTS:479916

WI-20576 (e-PCR)
- UniSTS:75214

RH46629 (e-PCR)
- UniSTS:72151

SHGC-84785 (e-PCR)
- UniSTS:104160

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables G-protein alpha-subunit binding	IBA Inferred from Biological aspect of Ancestor more info
enables G-protein alpha-subunit binding	IDA Inferred from Direct Assay more info	PubMed
enables G-protein beta-subunit binding	IBA Inferred from Biological aspect of Ancestor more info
enables beta-endorphin receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables beta-endorphin receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables morphine receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables morphine receptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables neuropeptide binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables voltage-gated calcium channel activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in G protein-coupled opioid receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in G protein-coupled opioid receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	TAS Traceable Author Statement more info	PubMed
involved_in adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in behavioral response to ethanol	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in calcium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in cellular response to morphine	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of Wnt protein secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cAMP-mediated signaling	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of cell population proliferation	TAS Traceable Author Statement more info	PubMed
involved_in negative regulation of cytosolic calcium ion concentration	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of nitric oxide biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in neuropeptide signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of ERK1 and ERK2 cascade	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cAMP-mediated signaling	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cytosolic calcium ion concentration	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of neurogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of nitric oxide biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of NMDA receptor activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of cellular response to stress	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sensory perception	NAS Non-traceable Author Statement more info	PubMed
involved_in sensory perception of pain	IBA Inferred from Biological aspect of Ancestor more info
involved_in sensory perception of pain	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	TAS Traceable Author Statement more info	PubMed
located_in axon	ISS Inferred from Sequence or Structural Similarity more info
located_in dendrite	ISS Inferred from Sequence or Structural Similarity more info
located_in endoplasmic reticulum	TAS Traceable Author Statement more info	PubMed
located_in endosome	ISS Inferred from Sequence or Structural Similarity more info
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
located_in perikaryon	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	TAS Traceable Author Statement more info
located_in synapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: mu-type opioid receptor

Names: mu opiate receptor; mu opioid receptor hMOR-1a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_021208.2 RefSeqGene

Range

33740..241367

Download

GenBank, FASTA, Sequence Viewer (Graphics), LRG_1007

mRNA and Protein(s)

NM_000914.5 → NP_000905.3 mu-type opioid receptor isoform MOR-1

See identical proteins and their annotated locations for NP_000905.3

Status: REVIEWED

Source sequence(s)

AL132774, AL136444

Consensus CDS

CCDS55070.1

UniProtKB/Swiss-Prot

B0FXJ1, B2R9S7, B8Q1L7, B8Q1L8, B8Q1L9, E7EWZ3, G8XRH6, G8XRH8, P35372, Q12930, Q4VWM1, Q4VWM2, Q4VWM3, Q4VWM4, Q4VWM6, Q4VWX6, Q5TDA1, Q6UPP1, Q6UQ80, Q7Z2D8, Q86V80, Q8IWW3, Q8IWW4, Q9UCZ4, Q9UN57

UniProtKB/TrEMBL

G8XRH5

Related

ENSP00000328264.7, ENST00000330432.12

Conserved Domains (1) summary

cd15090
Location:71 → 349

7tmA_Mu_opioid_R; opioid receptor subtype mu, member of the class A family of seven-transmembrane G protein-coupled receptors
NM_001008503.3 → NP_001008503.2 mu-type opioid receptor isoform MOR-1O

See identical proteins and their annotated locations for NP_001008503.2

Status: REVIEWED

Source sequence(s)

AL136444, AL445220

Consensus CDS

CCDS43517.1

UniProtKB/TrEMBL

G8XRH5

Related

ENSP00000338381.4, ENST00000337049.8

Conserved Domains (2) summary

pfam00001
Location:87 → 338

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:79 → 283

7tm_4; Olfactory receptor
NM_001008504.4 → NP_001008504.2 mu-type opioid receptor isoform MOR-1A

See identical proteins and their annotated locations for NP_001008504.2

Status: REVIEWED

Source sequence(s)

AL136444

Consensus CDS

CCDS47508.1

UniProtKB/TrEMBL

G8XRH5

Related

ENSP00000411903.2, ENST00000428397.6

Conserved Domains (2) summary

pfam00001
Location:87 → 338

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:79 → 283

7tm_4; Olfactory receptor
NM_001008505.2 → NP_001008505.2 mu-type opioid receptor isoform MOR-1X

Status: REVIEWED

Description

Transcript Variant: This variant (MOR-1X), also known as MOR-1R, represents use of an alternate promoter and 5' UTR, uses a downstream start codon, and uses an alternate 3' exon, compared to variant MOR-1i. The resulting isoform (MOR-1X) has a shorter N-terminus and a longer and distinct C-terminus, compared to isoform MOR-1i.

Source sequence(s)

AL136444, AY036622, FJ041291

Consensus CDS

CCDS43518.1

UniProtKB/TrEMBL

G8XRH5

Related

ENSP00000229768.5, ENST00000229768.9

Conserved Domains (2) summary

pfam00001
Location:87 → 338

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:79 → 283

7tm_4; Olfactory receptor
NM_001145279.4 → NP_001138751.1 mu-type opioid receptor isoform MOR-1i

See identical proteins and their annotated locations for NP_001138751.1

Status: REVIEWED

Source sequence(s)

AL132774, AL136444

Consensus CDS

CCDS47503.1

UniProtKB/TrEMBL

G8XRH5

Related

ENSP00000394624.2, ENST00000434900.6

Conserved Domains (1) summary

cd15090
Location:164 → 442

7tmA_Mu_opioid_R; opioid receptor subtype mu, member of the class A family of seven-transmembrane G protein-coupled receptors
NM_001145280.4 → NP_001138752.1 mu-type opioid receptor isoform MOR-1G1

See identical proteins and their annotated locations for NP_001138752.1

Status: REVIEWED

Source sequence(s)

AL132774, AL136444

Consensus CDS

CCDS55071.1

UniProtKB/TrEMBL

C7E9I8

Related

ENSP00000430876.1, ENST00000520708.5

Conserved Domains (1) summary

cd15090
Location:1 → 249

7tmA_Mu_opioid_R; opioid receptor subtype mu, member of the class A family of seven-transmembrane G protein-coupled receptors
NM_001145281.3 → NP_001138753.1 mu-type opioid receptor isoform MOR-1G2

See identical proteins and their annotated locations for NP_001138753.1

Status: REVIEWED

Source sequence(s)

AL132774, AL136444

Consensus CDS

CCDS55068.1

UniProtKB/TrEMBL

C7E9I8

Related

ENSP00000430260.1, ENST00000518759.5

Conserved Domains (1) summary

cd15090
Location:16 → 268

7tmA_Mu_opioid_R; opioid receptor subtype mu, member of the class A family of seven-transmembrane G protein-coupled receptors
NM_001145282.2 → NP_001138754.1 mu-type opioid receptor isoform MOR-1B1

See identical proteins and their annotated locations for NP_001138754.1

Status: REVIEWED

Description

Transcript Variant: This variant (MOR-1B1) represents use of an alternate promoter and 5' UTR, uses a downstream start codon, and uses an alternate 3' exon, compared to variant MOR-1i. The resulting isoform (MOR-1B1) has a shorter N-terminus and a longer and distinct C-terminus, compared to isoform MOR-1i.

Source sequence(s)

AL136444, AY225404, FJ041291

Consensus CDS

CCDS47504.1

UniProtKB/TrEMBL

G8XRH5

Related

ENSP00000410497.2, ENST00000452687.6

Conserved Domains (1) summary

cd15090
Location:71 → 349

7tmA_Mu_opioid_R; opioid receptor subtype mu, member of the class A family of seven-transmembrane G protein-coupled receptors
NM_001145283.2 → NP_001138755.1 mu-type opioid receptor isoform MOR-1B2

See identical proteins and their annotated locations for NP_001138755.1

Status: REVIEWED

Description

Transcript Variant: This variant (MOR-1B2) represents use of an alternate promoter and 5' UTR, uses a downstream start codon, and uses an alternate 3' exon, compared to variant MOR-1i. The resulting isoform (MOR-1B2) has a shorter N-terminus and a shorter and distinct C-terminus, compared to isoform MOR-1i.

Source sequence(s)

AL132774, AY309005, FJ041291

Consensus CDS

CCDS47505.1

UniProtKB/TrEMBL

G8XRH5

Related

ENSP00000413752.2, ENST00000435918.6

Conserved Domains (2) summary

pfam00001
Location:87 → 338

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:79 → 283

7tm_4; Olfactory receptor
NM_001145284.3 → NP_001138756.1 mu-type opioid receptor isoform MOR-1B3

See identical proteins and their annotated locations for NP_001138756.1

Status: REVIEWED

Description

Transcript Variant: This variant (MOR-1B3) represents use of an alternate promoter and 5' UTR, uses a downstream start codon, and uses an alternate 3' exon, compared to variant MOR-1i. The resulting isoform (MOR-1B3) has a shorter N-terminus and a longer and distinct C-terminus, compared to isoform MOR-1i.

Source sequence(s)

AL132774, AY309006, FJ041291

Consensus CDS

CCDS47506.1

UniProtKB/TrEMBL

G8XRH5

Related

ENSP00000399359.2, ENST00000414028.6

Conserved Domains (2) summary

pfam00001
Location:87 → 338

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:79 → 283

7tm_4; Olfactory receptor
NM_001145285.3 → NP_001138757.1 mu-type opioid receptor isoform MOR-1B4

Status: REVIEWED

Source sequence(s)

AL132774, AL136444

Consensus CDS

CCDS55069.1

UniProtKB/TrEMBL

G8XRH5

Related

ENSP00000430097.1, ENST00000524163.5

Conserved Domains (1) summary

cd15090
Location:71 → 349

7tmA_Mu_opioid_R; opioid receptor subtype mu, member of the class A family of seven-transmembrane G protein-coupled receptors
NM_001145286.3 → NP_001138758.1 mu-type opioid receptor isoform MOR-1B5

Status: REVIEWED

Source sequence(s)

AL132774, AL136444

Consensus CDS

CCDS47507.1

UniProtKB/TrEMBL

G8XRH5

Related

ENSP00000403549.2, ENST00000419506.6

Conserved Domains (1) summary

cd15090
Location:71 → 349

7tmA_Mu_opioid_R; opioid receptor subtype mu, member of the class A family of seven-transmembrane G protein-coupled receptors
NM_001145287.3 → NP_001138759.1 mu-type opioid receptor isoform MOR-1G1

See identical proteins and their annotated locations for NP_001138759.1

Status: REVIEWED

Description

Transcript Variant: This variant (MOR-1K1) represents use of an alternate promoter and 5' UTR and uses a downstream start codon, compared to variant MOR-1i. The resulting isoform (MOR-1G1) has a shorter N-terminus, compared to isoform MOR-1i. Variants MOR-1G1, MOR-1K1, and MOR-1K2 encode the same isoform (MOR-1G1).

Source sequence(s)

AL132774, AL136444, EU362990

Consensus CDS

CCDS55071.1

UniProtKB/TrEMBL

C7E9I8

Related

ENSP00000429373.1, ENST00000522236.1

Conserved Domains (1) summary

cd15090
Location:1 → 249

7tmA_Mu_opioid_R; opioid receptor subtype mu, member of the class A family of seven-transmembrane G protein-coupled receptors
NM_001285522.1 → NP_001272451.1 mu-type opioid receptor isoform MOR-1S

Status: REVIEWED

Description

Transcript Variant: This variant (MOR-1S) represents use of an alternate promoter and 5' UTR, uses a downstream start codon, and lacks two alternate internal exons, compared to variant MOR-1i. The resulting isoform (MOR-1S) has a shorter N-terminus and a shorter and distinct C-terminus, compared to isoform MOR-1i. An in-frame, upstream AUG is present that would extend the N-terminus by 62-aa, but the longer N-terminus is not annotated to conform to the annotation commonly used in the literature.

Source sequence(s)

AL132774, FJ041290, FJ041291

UniProtKB/TrEMBL

C9E9Z9

Conserved Domains (2) summary

cd14964
Location:73 → 96

7tm_GPCRs; TM helix 1 [structural motif]

cl28897
Location:71 → 96

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
NM_001285523.3 → NP_001272452.1 mu-type opioid receptor isoform MOR-1A2

See identical proteins and their annotated locations for NP_001272452.1

Status: REVIEWED

Source sequence(s)

AL136444

UniProtKB/TrEMBL

L0E130

Related

ENSP00000353598.5, ENST00000360422.8

Conserved Domains (2) summary

pfam00001
Location:87 → 338

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:79 → 283

7tm_4; Olfactory receptor
NM_001285524.1 → NP_001272453.1 mu-type opioid receptor isoform MOR-1i

See identical proteins and their annotated locations for NP_001272453.1

Status: REVIEWED

Description

Transcript Variant: This variant (MOR-1CA) represents use of an alternate promoter and 5' UTR, compared to variant MOR-1i. Variants MOR-1i and MOR-1CA encode the same isoform (MOR-1i).

Source sequence(s)

AL132774, FJ041292

Consensus CDS

CCDS47503.1

UniProtKB/TrEMBL

G8XRH5

Conserved Domains (1) summary

cd15090
Location:164 → 442

7tmA_Mu_opioid_R; opioid receptor subtype mu, member of the class A family of seven-transmembrane G protein-coupled receptors
NM_001285526.2 → NP_001272455.1 mu-type opioid receptor isoform MOR-1G1

See identical proteins and their annotated locations for NP_001272455.1

Status: REVIEWED

Description

Transcript Variant: This variant (MOR-1K2) represents use of an alternate promoter and 5' UTR and uses a downstream start codon, compared to variant MOR-1i. The resulting isoform (MOR-1G1) has a shorter N-terminus, compared to isoform MOR-1i. Variants MOR-1G1, MOR-1K1, and MOR-1K2 encode the same isoform (MOR-1G1).

Source sequence(s)

AL132774, AL136444, EU360599

Consensus CDS

CCDS55071.1

UniProtKB/TrEMBL

C7E9I8

Related

ENSP00000429719.1, ENST00000522555.5

Conserved Domains (1) summary

cd15090
Location:1 → 249

7tmA_Mu_opioid_R; opioid receptor subtype mu, member of the class A family of seven-transmembrane G protein-coupled receptors
NM_001285527.1 → NP_001272456.1 mu-type opioid receptor isoform MOR-1W

See identical proteins and their annotated locations for NP_001272456.1

Status: REVIEWED

Description

Transcript Variant: This variant (MOR-1W; also known as mu3-like and MOR-1A delta) represents use of an alternate promoter and 5' UTR, uses a downstream start codon, and uses an alternate 3' exon, compared to variant MOR-1i. The resulting isoform (MOR-1W) has a shorter N-terminus and a shorter and distinct C-terminus, compared to isoform MOR-1i.

Source sequence(s)

AY364890

UniProtKB/TrEMBL

C7E9I8

Related

ENST00000522382.1

Conserved Domains (2) summary

pfam00001
Location:1 → 238

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:56 → 183

7tm_4; Olfactory receptor
NM_001285528.2 → NP_001272457.1 mu-type opioid receptor isoform MOR-3

See identical proteins and their annotated locations for NP_001272457.1

Status: REVIEWED

Description

Transcript Variant: This variant (MOR-3; also known as mu3) represents use of an alternate promoter and 5' UTR, uses a downstream start codon, and uses an alternate 3' exon, compared to variant MOR-1i. The resulting isoform (MOR-3) has a shorter N-terminus and a shorter and distinct C-terminus, compared to isoform MOR-1i.

Source sequence(s)

AY195733, AY364890

UniProtKB/TrEMBL

C7E9I8

Related

ENST00000521106.1

Conserved Domains (2) summary

pfam00001
Location:1 → 238

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:56 → 183

7tm_4; Olfactory receptor

RNA

NR_104348.1 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (MOR-1Y3; also known as MOR-1V) represents use of an alternate promoter and contains an alternate internal exon, compared to variant MOR-1i. This variant is represented as non-coding because the use of the 5'-most translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AL132774, FJ041291, FJ041293, FJ041294
NR_104349.1 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (MOR-1Y2) represents use of an alternate promoter and contains an alternate internal exon, compared to variant MOR-1i. This variant is represented as non-coding because the use of the 5'-most translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AY225404, FJ041291, FJ041294
NR_104350.1 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (MOR-1Z) represents use of an alternate promoter and lacks an alternate internal exon, compared to variant MOR-1i. This variant is represented as non-coding because the use of the 5'-most translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AL132774, FJ041291, HQ699462
NR_104351.1 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (MOR-1Y) represents use of an alternate promoter and contains an alternate internal exon, compared to variant MOR-1i. This variant is represented as non-coding because the use of the 5'-most translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AL132774, AY309009, FJ041291

Related

ENST00000519083.5

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000006.12 Reference GRCh38.p14 Primary Assembly

Range

154010496..154246867

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047418837.1 → XP_047274793.1 mu-type opioid receptor isoform X2

UniProtKB/TrEMBL

A0A6H0WF09

Conserved Domains (2) summary

cd14964
Location:135 → 159

7tm_GPCRs; TM helix 1 [structural motif]

cl28897
Location:133 → 159

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
XM_017010907.3 → XP_016866396.1 mu-type opioid receptor isoform X3

UniProtKB/TrEMBL

G8XRH4

Conserved Domains (2) summary

cd14964
Location:135 → 159

7tm_GPCRs; TM helix 1 [structural motif]

cl28897
Location:133 → 180

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
XM_011535862.3 → XP_011534164.1 mu-type opioid receptor isoform X1

See identical proteins and their annotated locations for XP_011534164.1

UniProtKB/TrEMBL

C7E9I8

Conserved Domains (2) summary

pfam00001
Location:1 → 238

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:56 → 183

7tm_4; Olfactory receptor
XM_011535856.3 → XP_011534158.1 mu-type opioid receptor isoform X1

See identical proteins and their annotated locations for XP_011534158.1

UniProtKB/TrEMBL

C7E9I8

Conserved Domains (2) summary

pfam00001
Location:1 → 238

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:56 → 183

7tm_4; Olfactory receptor
XM_011535853.3 → XP_011534155.1 mu-type opioid receptor isoform X1

See identical proteins and their annotated locations for XP_011534155.1

UniProtKB/TrEMBL

C7E9I8

Conserved Domains (2) summary

pfam00001
Location:1 → 238

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:56 → 183

7tm_4; Olfactory receptor
XM_017010903.3 → XP_016866392.1 mu-type opioid receptor isoform X1

UniProtKB/TrEMBL

C7E9I8

Conserved Domains (2) summary

pfam00001
Location:1 → 238

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:56 → 183

7tm_4; Olfactory receptor
XM_011535851.4 → XP_011534153.1 mu-type opioid receptor isoform X1

See identical proteins and their annotated locations for XP_011534153.1

UniProtKB/TrEMBL

C7E9I8

Conserved Domains (2) summary

pfam00001
Location:1 → 238

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:56 → 183

7tm_4; Olfactory receptor
XM_017010904.2 → XP_016866393.1 mu-type opioid receptor isoform X1

UniProtKB/TrEMBL

C7E9I8

Conserved Domains (2) summary

pfam00001
Location:1 → 238

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:56 → 183

7tm_4; Olfactory receptor