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    ZNF165 zinc finger protein 165 [ Homo sapiens (human) ]

    Gene ID: 7718, updated on 10-Dec-2024

    Summary

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    Official Symbol
    ZNF165provided by HGNC
    Official Full Name
    zinc finger protein 165provided by HGNC
    Primary source
    HGNC:HGNC:12953
    See related
    Ensembl:ENSG00000197279 MIM:600834; AllianceGenome:HGNC:12953
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CT53; LD65; ZSCAN7
    Summary
    This gene encodes a member of the Kruppel family of zinc finger proteins. Members of this DNA-binding protein family act as transcriptional regulators. This gene is located within a cluster of zinc finger family members. The encoded protein may play a role in spermatogenesis. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in testis (RPKM 10.2), placenta (RPKM 2.3) and 15 other tissues See more
    Orthologs
    all
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    Genomic context

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    See ZNF165 in Genome Data Viewer
    Location:
    6p22.1
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (28080282..28089563)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (27950300..27959582)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (28048060..28057341)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 2 subfamily B member 8 (gene/pseudogene) Neighboring gene olfactory receptor family 1 subfamily F member 12, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24341 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24342 Neighboring gene zinc finger and SCAN domain containing 12 pseudogene 1 Neighboring gene zinc finger protein 601, pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. Frequent expression of zinc-finger protein ZNF165 in human urinary bladder transitional cell carcinoma. Singh PK, et al. Immunobiology, 2015 Jan. PMID 25214475
    2. Characterization of a novel zinc finger gene (ZNF165) mapping to 6p21 that is expressed specifically in testis. Tirosvoutis KN, et al. Genomics, 1995 Aug 10. PMID 7490084
    3. Familial t(6;21)(p21.1;p13) translocation associated with male-only sterility. Paoloni-Giacobino A, et al. Clin Genet, 2000 Oct. PMID 11076058
    4. ZNF165 Is Involved in the Regulation of Immune Microenvironment and Promoting the Proliferation and Migration of Hepatocellular Carcinoma by AhR/CYP1A1. Liu P, et al. J Immunol Res, 2022. PMID 35692498, Free PMC Article
    5. The testis protein ZNF165 is a SMAD3 cofactor that coordinates oncogenic TGFβ signaling in triple-negative breast cancer. Gibbs ZA, et al. Elife, 2020 Jun 9. PMID 32515734, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ZNF165 Is Involved in the Regulation of Immune Microenvironment and Promoting the Proliferation and Migration of Hepatocellular Carcinoma by AhR/CYP1A1.
      Title: ZNF165 Is Involved in the Regulation of Immune Microenvironment and Promoting the Proliferation and Migration of Hepatocellular Carcinoma by AhR/CYP1A1.
    2. The testis protein ZNF165 is a SMAD3 cofactor that coordinates oncogenic TGFbeta signaling in triple-negative breast cancer.
      Title: The testis protein ZNF165 is a SMAD3 cofactor that coordinates oncogenic TGFβ signaling in triple-negative breast cancer.
    3. ZNF165 drives the unrestrained activation of transforming growth factor beta (TGFbeta) signalling by directly inactivating the expression of negative feedback pathway regulators, SMURF2, SMAD7 and PMEPA1.
      Title: Comprehensive functional characterization of cancer-testis antigens defines obligate participation in multiple hallmarks of cancer.
    4. ZNF165 mRNA/protein expression was observed in TCC of human urinary bladder and might be used as a novel diagnostic biomarker and as well a vaccine target in development of urinary bladder cancer specific immunotherapy.
      Title: Frequent expression of zinc-finger protein ZNF165 in human urinary bladder transitional cell carcinoma.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 165
    Names
    cancer/testis antigen 53
    zinc finger and SCAN domain-containing protein 7

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001376491.1 → NP_001363420.1  zinc finger protein 165 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-4 all encode the same isoform (a).
      Source sequence(s)
      AL121944
      Consensus CDS
      CCDS4643.1
      UniProtKB/Swiss-Prot
      P49910
      UniProtKB/TrEMBL
      Q53Z40
      Related
      ENSP00000507525.1, ENST00000683778.1
      Conserved Domains (4) summary
      smart00431
      Location:45 → 157
      SCAN; leucine rich region
      COG5048
      Location:426 → 479
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:402 → 422
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:344 → 366
      zf-C2H2; Zinc finger, C2H2 type

    2. NM_001376492.1 → NP_001363421.1  zinc finger protein 165 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1-4 all encode the same isoform (a).
      Source sequence(s)
      AL121944
      Consensus CDS
      CCDS4643.1
      UniProtKB/Swiss-Prot
      P49910
      UniProtKB/TrEMBL
      Q53Z40
      Conserved Domains (4) summary
      smart00431
      Location:45 → 157
      SCAN; leucine rich region
      COG5048
      Location:426 → 479
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:402 → 422
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:344 → 366
      zf-C2H2; Zinc finger, C2H2 type

    3. NM_001376493.1 → NP_001363422.1  zinc finger protein 165 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1-4 all encode the same isoform (a).
      Source sequence(s)
      AL121944
      Consensus CDS
      CCDS4643.1
      UniProtKB/Swiss-Prot
      P49910
      UniProtKB/TrEMBL
      Q53Z40
      Conserved Domains (4) summary
      smart00431
      Location:45 → 157
      SCAN; leucine rich region
      COG5048
      Location:426 → 479
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:402 → 422
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:344 → 366
      zf-C2H2; Zinc finger, C2H2 type

    4. NM_001376494.1 → NP_001363423.1  zinc finger protein 165 isoform b

      Status: REVIEWED

      Source sequence(s)
      AL121944
      Conserved Domains (3) summary
      COG5048
      Location:234 → 287
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:210 → 230
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:152 → 174
      zf-C2H2; Zinc finger, C2H2 type

    5. NM_003447.4 → NP_003438.1  zinc finger protein 165 isoform a

      See identical proteins and their annotated locations for NP_003438.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1-4 all encode the same isoform (a).
      Source sequence(s)
      AL121944, AY083664
      Consensus CDS
      CCDS4643.1
      UniProtKB/Swiss-Prot
      P49910
      UniProtKB/TrEMBL
      Q53Z40
      Related
      ENSP00000366542.1, ENST00000377325.2
      Conserved Domains (4) summary
      smart00431
      Location:45 → 157
      SCAN; leucine rich region
      COG5048
      Location:426 → 479
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:402 → 422
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:344 → 366
      zf-C2H2; Zinc finger, C2H2 type

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      28080282..28089563
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017011261.3 → XP_016866750.1  zinc finger protein 165 isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      27950300..27959582
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054356329.1 → XP_054212304.1  zinc finger protein 165 isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P49910.1 GenPept UniProtKB/Swiss-Prot:P49910

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