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    ADORA1 adenosine A1 receptor [ Homo sapiens (human) ]

    Gene ID: 134, updated on 4-Jan-2025

    Summary

    Official Symbol
    ADORA1provided by HGNC
    Official Full Name
    adenosine A1 receptorprovided by HGNC
    Primary source
    HGNC:HGNC:262
    See related
    Ensembl:ENSG00000163485 MIM:102775; AllianceGenome:HGNC:262
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RDC7
    Summary
    The protein encoded by this gene is an adenosine receptor that belongs to the G-protein coupled receptor 1 family. There are 3 types of adenosine receptors, each with a specific pattern of ligand binding and tissue distribution, and together they regulate a diverse set of physiologic functions. The type A1 receptors inhibit adenylyl cyclase, and play a role in the fertilization process. Animal studies also suggest a role for A1 receptors in kidney function and ethanol intoxication. Transcript variants with alternative splicing in the 5' UTR have been found for this gene. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in brain (RPKM 15.5), testis (RPKM 10.4) and 8 other tissues See more
    Orthologs
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    Genomic context

    See ADORA1 in Genome Data Viewer
    Location:
    1q32.1
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (203127726..203167405)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (202390478..202430156)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (203096854..203136533)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene PTPRF interacting protein alpha 4 Neighboring gene uncharacterized LOC105371687 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2341 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:203044947-203045682 Neighboring gene NANOG hESC enhancer GRCh37_chr1:203056459-203056976 Neighboring gene myogenin promoter associated myogenic regulatory antisense long non coding RNA Neighboring gene myogenin Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:203096578-203097558 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:203103311-203104198 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:203112572-203113072 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:203114546-203115227 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:203134798-203134977 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:203135305-203135815 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:203135816-203136326 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:203138876-203139876 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:203143089-203143618 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr1:203146536-203147735 Neighboring gene myosin binding protein H Neighboring gene chitinase 3 like 1 Neighboring gene uncharacterized LOC124904485

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    BioGRID CRISPR Screen Phenotypes (17 hits/1266 screens)

    EBI GWAS Catalog

    Description
    Clozapine-induced agranulocytosis is associated with rare HLA-DQB1 and HLA-B alleles.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled adenosine receptor activity  
    enables G protein-coupled receptor binding  
    enables G-protein beta/gamma-subunit complex binding  
    enables heat shock protein binding  
    enables heterotrimeric G-protein binding  
    enables protein binding PubMed 
    enables protein heterodimerization activity  
    enables purine nucleoside binding  
    Items 1 - 25 of 49
    Process Evidence Code Pubs
    involved_in G protein-coupled adenosine receptor signaling pathway  
    involved_in G protein-coupled receptor signaling pathway  
    involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway  
    involved_in apoptotic signaling pathway PubMed 
    involved_in cell-cell signaling PubMed 
    involved_in cognition  
    involved_in detection of temperature stimulus involved in sensory perception of pain  
    involved_in excitatory postsynaptic potential  
    involved_in fatty acid homeostasis  
    involved_in inflammatory response PubMed 
    involved_in leukocyte migration  
    involved_in lipid catabolic process  
    involved_in long-term synaptic depression  
    involved_in mucus secretion  
    involved_in negative regulation of acute inflammatory response  
    involved_in negative regulation of apoptotic process  
    involved_in negative regulation of cell population proliferation  
    involved_in negative regulation of circadian sleep/wake cycle, non-REM sleep  
    involved_in negative regulation of glutamate secretion  
    involved_in negative regulation of hormone secretion  
    involved_in negative regulation of leukocyte migration  
    involved_in negative regulation of lipid catabolic process  
    involved_in negative regulation of long-term synaptic depression  
    involved_in negative regulation of long-term synaptic potentiation  
    involved_in negative regulation of mucus secretion  
    involved_in negative regulation of neurotrophin production  
    involved_in negative regulation of synaptic transmission, GABAergic  
    involved_in negative regulation of synaptic transmission, glutamatergic  
    involved_in negative regulation of systemic arterial blood pressure  
    involved_in nervous system development PubMed 
    involved_in phagocytosis PubMed 
    involved_in positive regulation of MAPK cascade  
    involved_in positive regulation of lipid catabolic process  
    involved_in positive regulation of nucleoside transport  
    involved_in positive regulation of peptide secretion  
    involved_in positive regulation of potassium ion transport  
    involved_in positive regulation of systemic arterial blood pressure  
    involved_in protein targeting to membrane  
    involved_in regulation of cardiac muscle cell contraction  
    involved_in regulation of glomerular filtration  
    involved_in regulation of presynaptic cytosolic calcium ion concentration  
    involved_in regulation of respiratory gaseous exchange by nervous system process  
    involved_in regulation of sensory perception of pain  
    involved_in response to hypoxia  
    involved_in response to purine-containing compound PubMed 
    involved_in signal transduction PubMed 
    involved_in temperature homeostasis  
    involved_in triglyceride homeostasis  
    involved_in vasodilation  
    Items 1 - 25 of 49
    Component Evidence Code Pubs
    located_in asymmetric synapse  
    located_in axolemma  
    located_in basolateral plasma membrane  
    located_in calyx of Held  
    is_active_in dendrite  
    located_in dendritic spine  
    located_in neuronal cell body  
    is_active_in plasma membrane  
    is_active_in plasma membrane PubMed 
    located_in plasma membrane PubMed 
    located_in plasma membrane  
    located_in postsynaptic membrane  
    located_in presynaptic active zone  
    located_in presynaptic membrane  
    is_active_in synapse  
    located_in terminal bouton  

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_052917.1 RefSeqGene

      Range
      5022..44701
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_000674.3 → NP_000665.1  adenosine receptor A1 isoform 1

      See identical proteins and their annotated locations for NP_000665.1

      Status: REVIEWED

      Source sequence(s)
      AC105940, BU740906, DB171678, L22214
      Consensus CDS
      CCDS1434.1
      UniProtKB/Swiss-Prot
      A6NFY5, A6NGP4, A8K1L3, B3KXQ4, D2CGD0, P30542, Q6FHK3, Q8TAM8
      Related
      ENSP00000338435.4, ENST00000337894.9
      Conserved Domains (2) summary
      pfam00001
      Location:26 → 288
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:18 → 137
      7tm_4; Olfactory receptor
    2. NM_001048230.2 → NP_001041695.1  adenosine receptor A1 isoform 1

      See identical proteins and their annotated locations for NP_001041695.1

      Status: REVIEWED

      Source sequence(s)
      AC105940, AK127752, BU740906, DA343445
      Consensus CDS
      CCDS1434.1
      UniProtKB/Swiss-Prot
      A6NFY5, A6NGP4, A8K1L3, B3KXQ4, D2CGD0, P30542, Q6FHK3, Q8TAM8
      Related
      ENSP00000356205.4, ENST00000367236.8
      Conserved Domains (2) summary
      pfam00001
      Location:26 → 288
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:18 → 137
      7tm_4; Olfactory receptor
    3. NM_001365065.1 → NP_001351994.1  adenosine receptor A1 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC105940
      UniProtKB/TrEMBL
      B7Z1L9, S5RC53
      Conserved Domains (2) summary
      cd14964
      Location:58 → 74
      7tm_GPCRs; TM helix 4 [structural motif]
      cl28897
      Location:46 → 231
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
    4. NM_001365066.1 → NP_001351995.1  adenosine receptor A1 isoform 3

      Status: REVIEWED

      Source sequence(s)
      AC105940
      Consensus CDS
      CCDS91146.1
      UniProtKB/TrEMBL
      S5RC53
      Conserved Domains (2) summary
      cd14964
      Location:10 → 26
      7tm_GPCRs; TM helix 4 [structural motif]
      cl28897
      Location:1 → 183
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      203127726..203167405
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047446499.1 → XP_047302455.1  adenosine receptor A1 isoform X1

      UniProtKB/TrEMBL
      B7Z379

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      202390478..202430156
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054334492.1 → XP_054190467.1  adenosine receptor A1 isoform X1

      UniProtKB/TrEMBL
      B7Z379
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