MESTIT1 MEST intronic transcript 1, antisense RNA [Homo sapiens (human)] - Gene

Summary

Official Symbol: MESTIT1provided by HGNC
Official Full Name: MEST intronic transcript 1, antisense RNAprovided by HGNC
Primary source: HGNC:HGNC:17991
See related: Ensembl:ENSG00000272701 MIM:607794; AllianceGenome:HGNC:17991
Gene type: ncRNA
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: MEST-IT; PEG1-AS; MEST-AS1; MEST-IT1; NCRNA00040
Summary: This gene encodes a non-protein coding antisense RNA that is imprinted, and preferentially expressed from the paternal allele. It is located in an intron of MEST gene in the opposite orientation, and shares the promoter region in common with one of the promoters (P2) of MEST gene. The antisense RNA is expressed predominantly in testis and mature motile spermatozoa, suggesting that it may be involved in the regulation of MEST expression during development.[provided by RefSeq, Oct 2010]
Expression: Biased expression in testis (RPKM 1.3), brain (RPKM 0.8) and 8 other tissues See more
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Genomic context

Location:: 7q32.2

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	7	NC_000007.14 (130486042..130490977, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	7	NC_060931.1 (131799763..131804698, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	7	NC_000007.13 (130125883..130130818, complement)

Chromosome 7 - NC_000007.14 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Tissue-specific circular RNA induction during human fetal development
Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
BioProject: PRJNA270632
Publication: PMID 26076956
Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MESTIT1, encoding a non-protein coding antisense RNA, is imprinted, with preferential expression from the paternal allele in all fetal tissues and fibroblasts examined.
Title: Identification and characterization of an imprinted antisense RNA (MESTIT1) in the human MEST locus on chromosome 7q32.
It can be excluded that genomic variants in MESTIT1 are involved in the aetiology of Silver-Russell syndrome
Title: Searching for genomic variants in the MESTIT1 transcript in Silver-Russell syndrome patients.

Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

General gene information

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Other Names

MEST intronic transcript 1 (non-protein coding)
paternally expressed gene, antisense transcript

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.