SPRY2 sprouty RTK signaling antagonist 2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: SPRY2provided by HGNC
Official Full Name: sprouty RTK signaling antagonist 2provided by HGNC
Primary source: HGNC:HGNC:11270
See related: Ensembl:ENSG00000136158 MIM:602466; AllianceGenome:HGNC:11270
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: IGAN3; hSPRY2
Summary: This gene encodes a protein belonging to the sprouty family. The encoded protein contains a carboxyl-terminal cysteine-rich domain essential for the inhibitory activity on receptor tyrosine kinase signaling proteins and is required for growth factor stimulated translocation of the protein to membrane ruffles. In primary dermal endothelial cells this gene is transiently upregulated in response to fibroblast growth factor two. This protein is indirectly involved in the non-cell autonomous inhibitory effect on fibroblast growth factor two signaling. The protein interacts with Cas-Br-M (murine) ectropic retroviral transforming sequence, and can function as a bimodal regulator of epidermal growth factor receptor/mitogen-activated protein kinase signaling. This protein may play a role in alveoli branching during lung development as shown by a similar mouse protein. [provided by RefSeq, Jul 2008]
Expression: Ubiquitous expression in fat (RPKM 17.3), gall bladder (RPKM 13.7) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 13q31.1

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	13	NC_000013.11 (80335976..80341126, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	13	NC_060937.1 (79564038..79569188, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	13	NC_000013.10 (80910111..80915261, complement)

Chromosome 13 - NC_000013.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Tissue-specific circular RNA induction during human fetal development
Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
BioProject: PRJNA270632
Publication: PMID 26076956
Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The Prognostic and Functional Impact of Sprouty 2 Expression in Non-small Cell Lung Cancer.
Title: The Prognostic and Functional Impact of Sprouty 2 Expression in Non-small Cell Lung Cancer.
The ceRNA Mechanism of lncRNA MEG3/miR-21-5p/SPRY2 in Cell Proliferation and Apoptosis in Bladder Cancer.
Title: The ceRNA Mechanism of lncRNA MEG3/miR-21-5p/SPRY2 in Cell Proliferation and Apoptosis in Bladder Cancer.
Loss of SPRY2 contributes to cancer-associated fibroblasts activation and promotes breast cancer development.
Title: Loss of SPRY2 contributes to cancer-associated fibroblasts activation and promotes breast cancer development.
SNHG12 regulates biological behaviors of ox-LDL-induced HA-VSMCs through upregulation of SPRY2 and NUB1.
Title: SNHG12 regulates biological behaviors of ox-LDL-induced HA-VSMCs through upregulation of SPRY2 and NUB1.
Epigenetic DNA Modifications Upregulate SPRY2 in Human Colorectal Cancers.
Title: Epigenetic DNA Modifications Upregulate SPRY2 in Human Colorectal Cancers.
Sprouty2 Inhibits Migration and Invasion of Fibroblast-Like Synoviocytes in Rheumatoid Arthritis by Down-regulating ATF2 Expression and Phosphorylation.
Title: Sprouty2 Inhibits Migration and Invasion of Fibroblast-Like Synoviocytes in Rheumatoid Arthritis by Down-regulating ATF2 Expression and Phosphorylation.
Sprouty2 positively regulates T cell function and airway inflammation through regulation of CSK and LCK kinases.
Title: Sprouty2 positively regulates T cell function and airway inflammation through regulation of CSK and LCK kinases.
Beta cell-specific deletion of the mouse ortholog of SPRY2 causes hyperglycemia and hypoinsulinemia.
Title: A Whole-Genome RNA Interference Screen Reveals a Role for Spry2 in Insulin Transcription and the Unfolded Protein Response.
MicroRNA-124 facilitates lens epithelial cell apoptosis by inhibiting SPRY2 and MMP-2.
Title: MicroRNA-124 facilitates lens epithelial cell apoptosis by inhibiting SPRY2 and MMP-2.
Sprouty2 limits intestinal tuft and goblet cell numbers through GSK3beta-mediated restriction of epithelial IL-33.
Title: Sprouty2 limits intestinal tuft and goblet cell numbers through GSK3β-mediated restriction of epithelial IL-33.

Submit: New GeneRIF Correction See all GeneRIFs (137)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
IgA nephropathy, susceptibility to, 3 MedGen: C4225194 OMIM: 616818 GeneReviews: Not available	not available

EBI GWAS Catalog

Description
A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study identifies ALLC polymorphisms correlated with FEV&#x02081; change by corticosteroid. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study identifies two susceptibility loci for nonsyndromic cleft lip with or without cleft palate. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide meta-analyses of nonsyndromic cleft lip with or without cleft palate identify six new risk loci. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility. EBI GWAS Catalog EBI GWAS CatalogPubMed
Identification of new genetic risk variants for type 2 diabetes. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Nef	nef	SPRY2 upregulation inhibits HIV-1 Gag-, Nef-, and Tat-specific T cell polyfunctionality independently of the PD-1 pathway	PubMed
Pr55(Gag)	gag	SPRY2 upregulation inhibits HIV-1 Gag-, Nef-, and Tat-specific T cell polyfunctionality independently of the PD-1 pathway	PubMed
	gag	SPRY2 interactions with PI(4,5)P2 and PLCgamma allow it to influence HIV-1 Gag release through interference with PI(4,5)P2 dynamics	PubMed
	gag	SPRY-mediated inhibition of HIV-1 Gag release is repressed by IP3R	PubMed
	gag	SPRY2 associates with ESCR-II component EAP20 to promote HIV-1 Gag release	PubMed
Tat	tat	SPRY2 upregulation inhibits HIV-1 Gag-, Nef-, and Tat-specific T cell polyfunctionality independently of the PD-1 pathway	PubMed
	tat	The expression of SPRY2 gene is upregulated in both Jurkat-Tat101 and Jurkat-Tat72 cells	PubMed

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SPRY2 (e-PCR)
- UniSTS:279139

G54033 (e-PCR)
- UniSTS:109415

RH44769 (e-PCR)
- UniSTS:40599

SHGC-85326 (e-PCR)
- UniSTS:104866

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein serine/threonine kinase activator activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein serine/threonine kinase inhibitor activity	IC Inferred by Curator more info	PubMed
enables ubiquitin-protein transferase inhibitor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in ERK1 and ERK2 cascade	IEA Inferred from Electronic Annotation more info
involved_in animal organ development	IBA Inferred from Biological aspect of Ancestor more info
involved_in bud elongation involved in lung branching	IEA Inferred from Electronic Annotation more info
involved_in cell fate commitment	IEA Inferred from Electronic Annotation more info
involved_in cellular response to leukemia inhibitory factor	IEA Inferred from Electronic Annotation more info
involved_in cellular response to vascular endothelial growth factor stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in establishment of mitotic spindle orientation	IEA Inferred from Electronic Annotation more info
involved_in fibroblast growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in inner ear morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in lung growth	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of ERK1 and ERK2 cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of ERK1 and ERK2 cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of ERK1 and ERK2 cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of ERK1 and ERK2 cascade	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of Ras protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cell projection organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of epithelial to mesenchymal transition	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of fibroblast growth factor receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of lens fiber cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of neurotrophin TRK receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of peptidyl-threonine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of protein ubiquitination	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of transforming growth factor beta receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of vascular endothelial growth factor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of ERK1 and ERK2 cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of epidermal growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of peptidyl-serine phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sensory perception of sound	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in actin cytoskeleton	IDA Inferred from Direct Assay more info
located_in cytoskeleton	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	TAS Traceable Author Statement more info
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in microtubule cytoskeleton	IDA Inferred from Direct Assay more info
located_in microtubule end	IDA Inferred from Direct Assay more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	TAS Traceable Author Statement more info
located_in ruffle membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: protein sprouty homolog 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_050650.1 RefSeqGene

Range

4990..10140

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001318536.1 → NP_001305465.1 protein sprouty homolog 2

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Transcript variants 1-4 encode the same protein.

Source sequence(s)

AK313810, BC015745

Consensus CDS

CCDS9463.1

UniProtKB/Swiss-Prot

B2R9J9, O43597, Q5T6Z7

UniProtKB/TrEMBL

Q7Z783

Conserved Domains (1) summary

pfam05210
Location:183 → 284

Sprouty; Sprouty protein (Spry)
NM_001318537.1 → NP_001305466.1 protein sprouty homolog 2

Status: REVIEWED

Description

Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Transcript variants 1-4 encode the same protein.

Source sequence(s)

AL713749, BC015745, DA230586

Consensus CDS

CCDS9463.1

UniProtKB/Swiss-Prot

B2R9J9, O43597, Q5T6Z7

UniProtKB/TrEMBL

Q7Z783

Related

ENSP00000366306.1, ENST00000377102.5

Conserved Domains (1) summary

pfam05210
Location:183 → 284

Sprouty; Sprouty protein (Spry)
NM_001318538.1 → NP_001305467.1 protein sprouty homolog 2

Status: REVIEWED

Description

Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1. Transcript variants 1-4 encode the same protein.

Source sequence(s)

AL713749, BC015745, DA160975, DA230586

Consensus CDS

CCDS9463.1

UniProtKB/Swiss-Prot

B2R9J9, O43597, Q5T6Z7

UniProtKB/TrEMBL

Q7Z783

Conserved Domains (1) summary

pfam05210
Location:183 → 284

Sprouty; Sprouty protein (Spry)
NM_005842.4 → NP_005833.1 protein sprouty homolog 2

See identical proteins and their annotated locations for NP_005833.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the predominant transcript. Transcript variants 1-4 encode the same protein.

Source sequence(s)

AL354668, BC015745, CX866409

Consensus CDS

CCDS9463.1

UniProtKB/Swiss-Prot

B2R9J9, O43597, Q5T6Z7

UniProtKB/TrEMBL

Q7Z783

Related

ENSP00000366308.3, ENST00000377104.4

Conserved Domains (1) summary

pfam05210
Location:183 → 284

Sprouty; Sprouty protein (Spry)