Pdk1 pyruvate dehydrogenase kinase 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Pdk1provided by RGD
Official Full Name: pyruvate dehydrogenase kinase 1provided by RGD
Primary source: RGD:69427
See related: EnsemblRapid:ENSRNOG00000001517 AllianceGenome:RGD:69427
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables ATP binding activity; identical protein binding activity; and pyruvate dehydrogenase (acetyl-transferring) kinase activity. Involved in cell surface receptor signaling pathway and peptidyl-serine phosphorylation. Part of pyruvate dehydrogenase complex. Orthologous to human PDK1 (pyruvate dehydrogenase kinase 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Heart (RPKM 619.9), Liver (RPKM 141.0) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q23

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (77113464..77144145)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (56705824..56733040)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (58530870..58561494)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Inhibition of the ubiquitin-proteasome system reduces the abundance of pyruvate dehydrogenase kinase 1 in cultured myotubes.
Title: Inhibition of the ubiquitin-proteasome system reduces the abundance of pyruvate dehydrogenase kinase 1 in cultured myotubes.
Epigenetic Metabolic Reprogramming of Right Ventricular Fibroblasts in Pulmonary Arterial Hypertension: A Pyruvate Dehydrogenase Kinase-Dependent Shift in Mitochondrial Metabolism Promotes Right Ventricular Fibrosis.
Title: Epigenetic Metabolic Reprogramming of Right Ventricular Fibroblasts in Pulmonary Arterial Hypertension: A Pyruvate Dehydrogenase Kinase-Dependent Shift in Mitochondrial Metabolism Promotes Right Ventricular Fibrosis.
The expression of three well-defined downstream targets of hypoxia inducible factor 1 alpha subunit (HIF-1alpha), pyruvate dehydrogenase kinase 1 (PDK1), lactate dehydrogenase A (LDHA) and vascular endothelial growth factor (VEGF), were up-regulated in hippocampus after 28 days of simulated microgravity exposure.
Title: Activation of HIF-1α and its downstream targets in rat hippocampus after long-term simulated microgravity exposure.
the present study identified 14 differentially expressed kinase genes in human bone marrow endothelial cells in liver fibrosis (LF) from the microarray data, including p38a, AKT1 and PDK1.the results from the present study indicate that the p38a kinase inhibitor, SB203580, may exhibit a protective effect on bone marrow tissues in rats with LF
Title: Screening of differentially expressed protein kinases in bone marrow endothelial cells and the protective effects of the p38a inhibitor SB203580 on bone marrow in liver fibrosis.
The interaction loci for the Pdk1/Pdk2 complex was characterized with mass spectrometry and nuclear magnetic resonance.
Title: Elucidation of the interaction loci of the human pyruvate dehydrogenase complex E2·E3BP core with pyruvate dehydrogenase kinase 1 and kinase 2 by H/D exchange mass spectrometry and nuclear magnetic resonance.
Over-activation of ROCK2 contributes to diabetic cardiomyopathy by multiple mechanisms, including direct phosphorylation and activation of protein kinase C beta II and interference with the PDK-1-mediated phosphorylation and activation of AKT.
Title: Complex regulation of PKCβ2 and PDK-1/AKT by ROCK2 in diabetic heart.
expression in hepatocytes increased under hypoxic culture conditions
Title: Liver epithelial cells proliferate under hypoxia and protect the liver from ischemic injury via expression of HIF-1 alpha target genes.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IDA Inferred from Direct Assay more info	PubMed
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	ISO Inferred from Sequence Orthology more info
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein-containing complex binding	IDA Inferred from Direct Assay more info	PubMed
enables pyruvate dehydrogenase (acetyl-transferring) kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables pyruvate dehydrogenase (acetyl-transferring) kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables pyruvate dehydrogenase (acetyl-transferring) kinase activity	IEA Inferred from Electronic Annotation more info
enables pyruvate dehydrogenase (acetyl-transferring) kinase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cell population proliferation	IEA Inferred from Electronic Annotation more info
involved_in cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in cell population proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in cell surface receptor signaling pathway	IMP Inferred from Mutant Phenotype more info
involved_in hypoxia-inducible factor-1alpha signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in hypoxia-inducible factor-1alpha signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in hypoxia-inducible factor-1alpha signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in intrinsic apoptotic signaling pathway in response to oxidative stress	IEA Inferred from Electronic Annotation more info
involved_in intrinsic apoptotic signaling pathway in response to oxidative stress	ISO Inferred from Sequence Orthology more info
involved_in intrinsic apoptotic signaling pathway in response to oxidative stress	ISS Inferred from Sequence or Structural Similarity more info
involved_in peptidyl-serine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of acetyl-CoA biosynthetic process from pyruvate	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of acetyl-CoA biosynthetic process from pyruvate	IEA Inferred from Electronic Annotation more info
involved_in regulation of acetyl-CoA biosynthetic process from pyruvate	ISO Inferred from Sequence Orthology more info
involved_in regulation of glucose metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of glucose metabolic process	IEA Inferred from Electronic Annotation more info
involved_in regulation of glucose metabolic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of glucose metabolic process	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in mitochondrial matrix	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info	PubMed
part_of pyruvate dehydrogenase complex	IDA Inferred from Direct Assay more info	PubMed
part_of pyruvate dehydrogenase complex	IEA Inferred from Electronic Annotation more info
part_of pyruvate dehydrogenase complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: pyruvate dehydrogenase kinase, isozyme 1

Names: PDH kinase 1; PDK p48; [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial; [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 1, mitochondrial; pyruvate dehydrogenase kinase, isoenzyme 1

NP_446278.2

EC 2.7.11.2

XP_006234414.1

EC 2.7.11.2

XP_038960041.1

EC 2.7.11.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053826.2 → NP_446278.2 pyruvate dehydrogenase kinase, isozyme 1 precursor

See identical proteins and their annotated locations for NP_446278.2

Status: PROVISIONAL

Source sequence(s)

BC089783

UniProtKB/TrEMBL

A0A8I6GMB0, F1MA54, Q5FVT5

Related

ENSRNOP00000002072.7, ENSRNOT00000002072.8

Conserved Domains (3) summary

smart00387
Location:268 → 388

HATPase_c; Histidine kinase-like ATPases

COG0642
Location:222 → 396

BaeS; Signal transduction histidine kinase [Signal transduction mechanisms]

pfam10436
Location:56 → 218

BCDHK_Adom3; Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086021.1 Reference GRCr8

Range

77113464..77144145

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006234352.5 → XP_006234414.1 pyruvate dehydrogenase kinase, isozyme 1 isoform X1

See identical proteins and their annotated locations for XP_006234414.1

UniProtKB/TrEMBL

A6HM58, A6HM61

Conserved Domains (3) summary

smart00387
Location:192 → 312

HATPase_c; Histidine kinase-like ATPases

COG0642
Location:146 → 320

BaeS; Signal transduction histidine kinase [Signal transduction mechanisms]

pfam10436
Location:2 → 142

BCDHK_Adom3; Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase
XM_039104113.2 → XP_038960041.1 pyruvate dehydrogenase kinase, isozyme 1 isoform X2

UniProtKB/TrEMBL

A6HM65

Conserved Domains (2) summary

cd16929
Location:67 → 233

HATPase_PDK-like; Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain alpha-ketoacid dehydrogenase kinase and related domains

pfam10436
Location:1 → 63

BCDHK_Adom3; Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase