Lrrc7 leucine rich repeat containing 7 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Lrrc7provided by RGD
Official Full Name: leucine rich repeat containing 7provided by RGD
Primary source: RGD:708527
See related: EnsemblRapid:ENSRNOG00000011980 AllianceGenome:RGD:708527
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables protein kinase binding activity. Involved in positive regulation of neuron projection development and response to organic cyclic compound. Located in several cellular components, including axon initial segment; dendritic spine; and filopodium. Is active in glutamatergic synapse and postsynaptic density membrane. Human ortholog(s) of this gene implicated in cocaine dependence. Orthologous to human LRRC7 (leucine rich repeat containing 7). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward (RPKM 189.0) See more
Orthologs: human mouse all
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Genomic context

Location:: 2q45

Exon count:: 29

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (249792441..250294267, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (247146616..247634945, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (264910594..265300860, complement)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Analysis of densin at the ultrastructural level reveals potential sites that can support specific interactions of densin. Densin molecules firmly embedded within the postsynaptic densities (PSD) may target a minor pool of CaMKII to substrates at the PSD core
Title: Distribution of densin in neurons.
topology of densin involves the membrane association configuration
Title: Densin-180 is not a transmembrane protein.
Characterization of a central Ca2+/calmodulin-dependent protein kinase IIalpha/beta binding domain in densin that selectively modulates glutamate receptor subunit phosphorylation.
Title: Characterization of a central Ca2+/calmodulin-dependent protein kinase IIalpha/beta binding domain in densin that selectively modulates glutamate receptor subunit phosphorylation.
Densin splice variants play multiple functional roles during neuronal development of the brain.
Title: Developmentally regulated alternative splicing of densin modulates protein-protein interaction and subcellular localization.
CAMKII isoforms interact with the postsynaptic density proteins NR2B, densin-180, and alpha-actinin-2
Title: Multivalent interactions of calcium/calmodulin-dependent protein kinase II with the postsynaptic density proteins NR2B, densin-180, and alpha-actinin-2.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cell-cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in establishment or maintenance of epithelial cell apical/basal polarity	IBA Inferred from Biological aspect of Ancestor more info
involved_in neurotransmitter receptor transport postsynaptic membrane to endosome	IBA Inferred from Biological aspect of Ancestor more info
involved_in neurotransmitter receptor transport, endosome to postsynaptic membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of neuron projection development	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of neuron projection development	IDA Inferred from Direct Assay more info	PubMed
involved_in receptor clustering	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to organic cyclic compound	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in actin cytoskeleton	IDA Inferred from Direct Assay more info	PubMed
is_active_in adherens junction	IBA Inferred from Biological aspect of Ancestor more info
is_active_in axon initial segment	IBA Inferred from Biological aspect of Ancestor more info
located_in axon initial segment	IDA Inferred from Direct Assay more info	PubMed
is_active_in basolateral plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in centrosome	IEA Inferred from Electronic Annotation more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	TAS Traceable Author Statement more info
located_in dendritic spine	IDA Inferred from Direct Assay more info	PubMed
located_in filopodium	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic density	IBA Inferred from Biological aspect of Ancestor more info
is_active_in postsynaptic density membrane	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with postsynaptic membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: leucine-rich repeat-containing protein 7

Names: densin 13T-16; densin 13T-17; densin 13T-23; densin 13T-29; densin 13T-41; densin 13T-43; densin 13T-57; densin 13T-57C; densin 13T-72; densin 13T-89; densin-180

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001393674.1 → NP_001380603.1 leucine-rich repeat-containing protein 7 isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000002

UniProtKB/Swiss-Prot

P70587, Q9JI42

UniProtKB/TrEMBL

F1M4K6

Related

ENSRNOP00000059517.4, ENSRNOT00000066024.6

Conserved Domains (3) summary

COG4886
Location:97 → 407

LRR; Leucine-rich repeat (LRR) protein [Transcription]

cd00992
Location:1452 → 1537

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

sd00033
Location:31 → 52

LRR_RI; leucine-rich repeat [structural motif]
NM_057142.2 → NP_476483.1 leucine-rich repeat-containing protein 7 isoform 2

See identical proteins and their annotated locations for NP_476483.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000002

UniProtKB/Swiss-Prot

P70587, Q9JI42

UniProtKB/TrEMBL

A6HWU2

Related

ENSRNOP00000093706.2, ENSRNOT00000116114.2

Conserved Domains (4) summary

cd00116
Location:166 → 406

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

cd00992
Location:1405 → 1490

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

sd00033
Location:31 → 52

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:144 → 199

LRR_8; Leucine rich repeat

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086020.1 Reference GRCr8

Range

249792441..250294267 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063281188.1 → XP_063137258.1 leucine-rich repeat-containing protein 7 isoform X8

UniProtKB/Swiss-Prot

P70587, Q9JI42
XM_063281182.1 → XP_063137252.1 leucine-rich repeat-containing protein 7 isoform X2

UniProtKB/Swiss-Prot

P70587, Q9JI42
XM_063281185.1 → XP_063137255.1 leucine-rich repeat-containing protein 7 isoform X5

UniProtKB/Swiss-Prot

P70587, Q9JI42
XM_063281181.1 → XP_063137251.1 leucine-rich repeat-containing protein 7 isoform X1

UniProtKB/Swiss-Prot

P70587, Q9JI42
XM_063281186.1 → XP_063137256.1 leucine-rich repeat-containing protein 7 isoform X6

UniProtKB/Swiss-Prot

P70587, Q9JI42
XM_063281189.1 → XP_063137259.1 leucine-rich repeat-containing protein 7 isoform X9

UniProtKB/Swiss-Prot

P70587, Q9JI42
XM_063281190.1 → XP_063137260.1 leucine-rich repeat-containing protein 7 isoform X10

UniProtKB/Swiss-Prot

P70587, Q9JI42
XM_063281187.1 → XP_063137257.1 leucine-rich repeat-containing protein 7 isoform X7

UniProtKB/Swiss-Prot

P70587, Q9JI42

UniProtKB/TrEMBL

A0A8I5ZTY2
XM_063281183.1 → XP_063137253.1 leucine-rich repeat-containing protein 7 isoform X3

UniProtKB/Swiss-Prot

P70587, Q9JI42

UniProtKB/TrEMBL

A0A8I6G9P9

Related

ENSRNOP00000082626.1, ENSRNOT00000115389.2
XM_063281191.1 → XP_063137261.1 leucine-rich repeat-containing protein 7 isoform X11
XM_063281184.1 → XP_063137254.1 leucine-rich repeat-containing protein 7 isoform X4

UniProtKB/Swiss-Prot

P70587, Q9JI42
XM_063281192.1 → XP_063137262.1 leucine-rich repeat-containing protein 7 isoform X12