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    Poldip3 DNA polymerase delta interacting protein 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 315170, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Poldip3provided by RGD
    Official Full Name
    DNA polymerase delta interacting protein 3provided by RGD
    Primary source
    RGD:1311073
    See related
    EnsemblRapid:ENSRNOG00000022877 AllianceGenome:RGD:1311073
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable mRNA binding activity. Predicted to be involved in poly(A)+ mRNA export from nucleus and positive regulation of translation. Predicted to be located in cytoplasmic ribonucleoprotein granule. Predicted to be active in nuclear speck. Orthologous to human POLDIP3 (DNA polymerase delta interacting protein 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 271.0), Spleen (RPKM 255.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Poldip3 in Genome Data Viewer
    Location:
    7q34
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (116154892..116183319, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (114274845..114303278, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (123992167..124020596, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103692952 Neighboring gene serine hydrolase-like 2 Neighboring gene ribosomal RNA processing 7 homolog A Neighboring gene transfer RNA proline (anticodon AGG) 38 Neighboring gene RNA, U12 small nuclear

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. SKAR is a specific target of S6 kinase 1 in cell growth control. Richardson CJ, et al. Curr Biol, 2004 Sep 7. PMID 15341740
    2. The proteins PDIP3 and ZC11A associate with the human TREX complex in an ATP-dependent manner and function in mRNA export. Folco EG, et al. PLoS One, 2012. PMID 22928037, Free PMC Article
    3. ATP is required for interactions between UAP56 and two conserved mRNA export proteins, Aly and CIP29, to assemble the TREX complex. Dufu K, et al. Genes Dev, 2010 Sep 15. PMID 20844015, Free PMC Article
    4. SKAR links pre-mRNA splicing to mTOR/S6K1-mediated enhanced translation efficiency of spliced mRNAs. Ma XM, et al. Cell, 2008 Apr 18. PMID 18423201
    5. Sequential Elution Interactome Analysis of the Mind Bomb 1 Ubiquitin Ligase Reveals a Novel Role in Dendritic Spine Outgrowth. Mertz J, et al. Mol Cell Proteomics, 2015 Jul. PMID 25931508, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in poly(A)+ mRNA export from nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in poly(A)+ mRNA export from nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of translation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasmic ribonucleoprotein granule IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic ribonucleoprotein granule ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nuclear speck IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    polymerase delta-interacting protein 3
    Names
    polymerase (DNA) delta interacting protein 3
    polymerase (DNA-directed), delta interacting protein 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001130506.1 → NP_001123978.1  polymerase delta-interacting protein 3

      See identical proteins and their annotated locations for NP_001123978.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473950
      UniProtKB/TrEMBL
      A0A0G2JXM5, A6HT84
      Related
      ENSRNOP00000070332.3, ENSRNOT00000082524.3
      Conserved Domains (2) summary
      COG0724
      Location:216 → 406
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12681
      Location:280 → 348
      RRM_SKAR; RNA recognition motif in S6K1 Aly/REF-like target (SKAR) and similar proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      116154892..116183319 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006242090.3 → XP_006242152.1  polymerase delta-interacting protein 3 isoform X1

      See identical proteins and their annotated locations for XP_006242152.1

      UniProtKB/TrEMBL
      A0A0G2JXM5, A6HT83, D4A2B0
      Related
      ENSRNOP00000052842.3, ENSRNOT00000055988.5
      Conserved Domains (2) summary
      COG0724
      Location:187 → 377
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12681
      Location:251 → 319
      RRM_SKAR; RNA recognition motif in S6K1 Aly/REF-like target (SKAR) and similar proteins

    2. XM_063263621.1 → XP_063119691.1  polymerase delta-interacting protein 3 isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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    Other Literature Sources
    Chemical Information
    Molecular Biology Databases
    Research Materials
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