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    Aacs acetoacetyl-CoA synthetase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 65984, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Aacsprovided by RGD
    Official Full Name
    acetoacetyl-CoA synthetaseprovided by RGD
    Primary source
    RGD:708522
    See related
    EnsemblRapid:ENSRNOG00000000967 AllianceGenome:RGD:708522
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables acetoacetate-CoA ligase activity and short-chain fatty acid-CoA ligase activity. Involved in several processes, including cellular response to cholesterol; cellular response to testosterone stimulus; and positive regulation of insulin secretion. Predicted to be located in cytosol. Biomarker of obesity. Orthologous to human AACS (acetoacetyl-CoA synthetase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 195.5), Brain (RPKM 119.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Aacs in Genome Data Viewer
    Location:
    12q14
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (36774471..36817835, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (31113098..31156411, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (36512393..36555694, complement)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene transmembrane protein 132B Neighboring gene uncharacterized LOC134481289 Neighboring gene uncharacterized LOC120095961 Neighboring gene Bri3 binding protein Neighboring gene DEAH-box helicase 37

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. cDNA-derived amino acid sequence of acetoacetyl-CoA synthetase from rat liver. Iwahori A, et al. FEBS Lett, 2000 Jan 28. PMID 10682835
    2. Utlization of D-3-hydroxy[3-14C]butyrate for lipogenesis in vivo in lactating rat mammary gland. Robinson AM, et al. Biochem J, 1978 Nov 15. PMID 33671, Free PMC Article
    3. Stimulation of hepatic cholesterol biosynthesis by fatty acids. Effects of oleate on cytoplasmic acetoacetyl-CoA thiolase, acetoacetyl-CoA synthetase and hydroxymethylglutaryl-CoA synthase. Salam WH, et al. Biochem J, 1989 Mar 1. PMID 2565110, Free PMC Article
    4. Acetoacetyl-CoA synthetase specific activity and concentration in rat tissues. Ito M, et al. Biochim Biophys Acta, 1986 Apr 15. PMID 3082367
    5. Acetoacetyl-CoA ligase activity in the isolated rat hepatocyte: effects of 25-hydroxycholesterol and high density lipoprotein. Wong GA, et al. Biosci Rep, 1987 Mar. PMID 3663886

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Prenatal nicotine exposure can cause DNA hypermethylation of the AACS promoter in the rat fetal adrenal.
      Title: DNA hypermethylation of acetoacetyl-CoA synthetase contributes to inhibited cholesterol supply and steroidogenesis in fetal rat adrenals under prenatal nicotine exposure.
    2. As acetoacetyl-CoA synthetase was expressed in neural-like cells, ketone bodies are assumed to be utilized for the synthesis of lipidic substances and to cause metabolic disorders in the nervous system of genetically obese rats.
      Title: Genetic obesity affects neural ketone body utilization in the rat brain.
    3. AACS in adipose tissue plays an important role in utilizing ketone body for the fatty acid-synthesis during adipose tissue development
      Title: Acetoacetyl-CoA synthetase gene is abundant in rat adipose, and related with fatty acid synthesis in mature adipocytes.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables acetoacetate-CoA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables acetoacetate-CoA ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables acetoacetate-CoA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables acetoacetate-CoA ligase activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables short-chain fatty acid-CoA ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in adipose tissue development IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in cellular response to cholesterol IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in cellular response to glucose stimulus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellular response to testosterone stimulus IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in fatty acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in liver development IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of insulin secretion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of insulin secretion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to ethanol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to nutrient IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to oleic acid IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to organic cyclic compound IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to purine-containing compound IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to starvation IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to xenobiotic stimulus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in white fat cell differentiation IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    acetoacetyl-CoA synthetase
    Names
    AcAc-CoA ligase
    acetoacetate-CoA ligase
    acetoacetyl-CoA ligase
    NP_075592.1
    XP_038945669.1
    XP_063127716.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_023104.2 → NP_075592.1  acetoacetyl-CoA synthetase

      See identical proteins and their annotated locations for NP_075592.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000012
      UniProtKB/Swiss-Prot
      Q9JMI1
      UniProtKB/TrEMBL
      A0A8I5ZR35, A6J0W1
      Related
      ENSRNOP00000081188.2, ENSRNOT00000102410.2
      Conserved Domains (1) summary
      TIGR01217
      Location:16 → 671
      ac_ac_CoA_syn; acetoacetyl-CoA synthase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      36774471..36817835 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063271646.1 → XP_063127716.1  acetoacetyl-CoA synthetase isoform X2

    2. XM_039089741.2 → XP_038945669.1  acetoacetyl-CoA synthetase isoform X1

      Conserved Domains (1) summary
      TIGR01217
      Location:1 → 527
      ac_ac_CoA_syn; acetoacetyl-CoA synthase
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9JMI1.1 GenPept UniProtKB/Swiss-Prot:Q9JMI1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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