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    Camk2a calcium/calmodulin-dependent protein kinase II alpha [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25400, updated on 4-Jan-2025

    Summary

    Official Symbol
    Camk2aprovided by RGD
    Official Full Name
    calcium/calmodulin-dependent protein kinase II alphaprovided by RGD
    Primary source
    RGD:2261
    See related
    EnsemblRapid:ENSRNOG00000018712 AllianceGenome:RGD:2261
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    PKCCD; PK2CDD
    Summary
    Enables GTPase activating protein binding activity and calcium/calmodulin-dependent protein kinase activity. Involved in several processes, including neurotransmitter receptor transport to plasma membrane; protein phosphorylation; and regulation of protein localization to cell periphery. Located in axon; dendrite cytoplasm; and neuronal cell body. Is active in several cellular components, including postsynaptic cytosol; postsynaptic density; and presynaptic cytosol. Biomarker of middle cerebral artery infarction and transient cerebral ischemia. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 53 and autosomal recessive intellectual developmental disorder 63. Orthologous to human CAMK2A (calcium/calmodulin dependent protein kinase II alpha). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in Brain (RPKM 681.4) and Muscle (RPKM 138.5) See more
    Orthologs
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    Genomic context

    See Camk2a in Genome Data Viewer
    Location:
    18q12.1
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (56648779..56711505)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (54378642..54441120)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (56193978..56295869)

    Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102550733 Neighboring gene arylsulfatase family, member I Neighboring gene solute carrier family 6 member 7 Neighboring gene caudal type homeo box 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding  
    enables GTPase activating protein binding PubMed 
    enables calcium/calmodulin-dependent protein kinase activity  
    enables calcium/calmodulin-dependent protein kinase activity PubMed 
    enables calcium/calmodulin-dependent protein kinase activity  
    enables calcium/calmodulin-dependent protein kinase activity  
    enables calmodulin binding  
    enables calmodulin binding  
    enables calmodulin binding  
    enables glutamate receptor binding  
    enables glutamate receptor binding  
    enables identical protein binding  
    enables kinase activity  
    enables metal ion binding  
    enables protein binding PubMed 
    enables protein homodimerization activity  
    enables protein homodimerization activity  
    enables protein serine kinase activity  
    enables protein serine/threonine kinase activity  
    enables protein serine/threonine kinase activity  
    Items 1 - 25 of 54
    Process Evidence Code Pubs
    acts_upstream_of_or_within G1/S transition of mitotic cell cycle  
    involved_in G1/S transition of mitotic cell cycle  
    involved_in angiotensin-activated signaling pathway  
    involved_in angiotensin-activated signaling pathway  
    acts_upstream_of_or_within calcium ion transport  
    involved_in calcium ion transport  
    involved_in cellular response to interferon-beta  
    involved_in cellular response to interferon-beta  
    involved_in cellular response to interferon-beta  
    involved_in cellular response to type II interferon  
    involved_in cellular response to type II interferon  
    acts_upstream_of_or_within dendrite morphogenesis  
    involved_in dendritic spine development  
    involved_in dendritic spine development  
    involved_in dendritic spine development  
    involved_in ionotropic glutamate receptor signaling pathway PubMed 
    involved_in negative regulation of hydrolase activity  
    involved_in negative regulation of hydrolase activity  
    involved_in neurotransmitter receptor transport to plasma membrane PubMed 
    involved_in peptidyl-serine phosphorylation PubMed 
    acts_upstream_of_or_within peptidyl-serine phosphorylation  
    involved_in peptidyl-threonine autophosphorylation  
    involved_in peptidyl-threonine autophosphorylation  
    involved_in positive regulation of NF-kappaB transcription factor activity  
    acts_upstream_of_or_within positive regulation of calcium ion transport  
    involved_in positive regulation of calcium ion transport  
    acts_upstream_of_or_within positive regulation of cardiac muscle cell apoptotic process  
    involved_in positive regulation of cardiac muscle cell apoptotic process  
    involved_in positive regulation of receptor signaling pathway via JAK-STAT  
    involved_in positive regulation of receptor signaling pathway via JAK-STAT  
    involved_in positive regulation of receptor signaling pathway via JAK-STAT  
    involved_in protein autophosphorylation PubMed 
    acts_upstream_of_or_within protein autophosphorylation  
    involved_in protein phosphorylation PubMed 
    involved_in protein phosphorylation  
    involved_in regulation of endocannabinoid signaling pathway  
    involved_in regulation of endocannabinoid signaling pathway  
    acts_upstream_of_or_within regulation of mitochondrial membrane permeability involved in apoptotic process  
    involved_in regulation of mitochondrial membrane permeability involved in apoptotic process  
    involved_in regulation of neuron migration  
    involved_in regulation of neuron migration  
    involved_in regulation of neuron migration  
    involved_in regulation of neuronal synaptic plasticity  
    acts_upstream_of_or_within regulation of neuronal synaptic plasticity  
    involved_in regulation of neuronal synaptic plasticity  
    involved_in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane PubMed 
    involved_in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane PubMed 
    acts_upstream_of_or_within regulation of neurotransmitter secretion  
    involved_in regulation of neurotransmitter secretion  
    involved_in regulation of protein localization to plasma membrane  
    involved_in regulation of protein localization to plasma membrane PubMed 
    involved_in regulation of synaptic vesicle docking  
    acts_upstream_of_or_within response to ischemia  
    involved_in response to ischemia  
    Items 1 - 25 of 54
    Items 1 - 20 of 24
    Component Evidence Code Pubs
    is_active_in Schaffer collateral - CA1 synapse  
    located_in axon PubMed 
    part_of calcium- and calmodulin-dependent protein kinase complex  
    part_of calcium- and calmodulin-dependent protein kinase complex  
    part_of calcium- and calmodulin-dependent protein kinase complex  
    is_active_in cytoplasm  
    located_in cytosol  
    located_in dendrite PubMed 
    located_in dendrite cytoplasm PubMed 
    located_in dendritic spine  
    located_in dendritic spine  
    located_in dendritic spine  
    is_active_in glutamatergic synapse PubMed 
    is_active_in glutamatergic synapse PubMed 
    located_in mitochondrion  
    located_in mitochondrion  
    is_active_in neuron projection  
    located_in neuronal cell body PubMed 
    is_active_in postsynaptic cytosol PubMed 
    is_active_in postsynaptic density  
    is_active_in postsynaptic density PubMed 
    located_in postsynaptic density  
    is_active_in presynaptic cytosol PubMed 
    located_in synapse  
    Items 1 - 20 of 24

    General protein information

    Preferred Names
    calcium/calmodulin-dependent protein kinase type II subunit alpha
    Names
    Ca2+/calmodulin-dependent protein kinase II alpha
    alpha CaM kinase II
    caM kinase II subunit alpha
    caM-kinase II alpha chain
    caMK-II subunit alpha
    calcium/calmodulin-dependent protein kinase (CaM kinase) II alpha
    calcium/calmodulin-dependent protein kinase II alpha subunit
    calcium/calmodulin-dependent protein kinase type II alpha chain
    NP_037052.1
    XP_038952520.1
    XP_038952521.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012920.1NP_037052.1  calcium/calmodulin-dependent protein kinase type II subunit alpha

      See identical proteins and their annotated locations for NP_037052.1

      Status: PROVISIONAL

      Source sequence(s)
      J02942
      UniProtKB/Swiss-Prot
      P11275
      UniProtKB/TrEMBL
      A0A8I6AHE3, A6IXE8
      Conserved Domains (2) summary
      cd14086
      Location:11302
      STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
      pfam08332
      Location:346473
      CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086036.1 Reference GRCr8

      Range
      56648779..56711505
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039096592.2XP_038952520.1  calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1

      UniProtKB/TrEMBL
      A0A0G2JUV8, F1LZG4
      Related
      ENSRNOP00000093893.2, ENSRNOT00000101374.2
      Conserved Domains (2) summary
      cd14086
      Location:11302
      STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
      pfam08332
      Location:357484
      CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
    2. XM_039096593.2XP_038952521.1  calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X2

      UniProtKB/TrEMBL
      A0A8I6AHE3
      Related
      ENSRNOP00000069249.2, ENSRNOT00000080177.3
      Conserved Domains (2) summary
      cd14086
      Location:11302
      STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
      pfam08332
      Location:346473
      CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
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