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    Asah1 N-acylsphingosine amidohydrolase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 84431, updated on 9-Dec-2024

    Summary

    Official Symbol
    Asah1provided by RGD
    Official Full Name
    N-acylsphingosine amidohydrolase 1provided by RGD
    Primary source
    RGD:621568
    See related
    EnsemblRapid:ENSRNOG00000010034 AllianceGenome:RGD:621568
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Asah
    Summary
    Predicted to enable N-acylsphingosine amidohydrolase activity; nuclear receptor binding activity; and transcription corepressor activity. Involved in lung development. Predicted to be located in extracellular space; lysosome; and nucleus. Human ortholog(s) of this gene implicated in Farber lipogranulomatosis; sphingolipidosis; and spinal muscular atrophy with progressive myoclonic epilepsy. Orthologous to human ASAH1 (N-acylsphingosine amidohydrolase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 539.6), Adrenal (RPKM 529.3) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Asah1 in Genome Data Viewer
    Location:
    16q12.1
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (57669927..57701349)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (50966404..50997827)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (53998604..54030006)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120097486 Neighboring gene uncharacterized LOC102547443 Neighboring gene FSHD region gene 1 Neighboring gene pericentriolar material 1 Neighboring gene fibrinogen-like 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in cellular response to tumor necrosis factor  
    involved_in cellular response to tumor necrosis factor  
    involved_in cellular response to tumor necrosis factor  
    involved_in ceramide biosynthetic process  
    involved_in ceramide biosynthetic process  
    involved_in ceramide catabolic process  
    involved_in ceramide catabolic process  
    involved_in ceramide catabolic process  
    involved_in fatty acid metabolic process  
    involved_in keratinocyte differentiation  
    involved_in keratinocyte differentiation  
    involved_in lung development PubMed 
    involved_in regulation of programmed necrotic cell death  
    involved_in regulation of programmed necrotic cell death  
    involved_in regulation of programmed necrotic cell death  
    involved_in regulation of steroid biosynthetic process  
    involved_in regulation of steroid biosynthetic process  
    involved_in sphingolipid metabolic process  
    involved_in sphingosine biosynthetic process  
    involved_in sphingosine biosynthetic process  
    involved_in sphingosine biosynthetic process  
    Component Evidence Code Pubs
    NOT located_in early endosome  
    NOT located_in endoplasmic reticulum  
    located_in extracellular region  
    located_in extracellular space  
    located_in extracellular space  
    located_in lysosome  
    located_in lysosome  
    located_in lysosome  
    located_in membrane  
    located_in nucleus  
    located_in nucleus  

    General protein information

    Preferred Names
    acid ceramidase
    Names
    AC
    ACDase
    N-acylethanolamine hydrolase ASAH1
    N-acylsphingosine amidohydrolase (acid ceramidase) 1
    acid CDase
    acylsphingosine deacylase
    NP_445859.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053407.3NP_445859.2  acid ceramidase precursor

      See identical proteins and their annotated locations for NP_445859.2

      Status: PROVISIONAL

      Source sequence(s)
      BC061540
      UniProtKB/Swiss-Prot
      Q6P7S1, Q9EQJ6
      UniProtKB/TrEMBL
      A0A8L2Q768
      Related
      ENSRNOP00000109066.1, ENSRNOT00000154244.1
      Conserved Domains (2) summary
      cd01903
      Location:133377
      Ntn_AC_NAAA; AC_NAAA This conserved domain includes two closely related proteins, acid ceramidase (AC, also known as N-acylsphingosine amidohydrolase), and N-acylethanolamine-hydrolyzing acid amidase (NAAA). AC catalyzes the hydrolysis of ceramide to sphingosine and ...
      pfam15508
      Location:44105
      NAAA-beta; beta subunit of N-acylethanolamine-hydrolyzing acid amidase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      57669927..57701349
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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