Clcn7 chloride voltage-gated channel 7 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Clcn7provided by RGD
Official Full Name: chloride voltage-gated channel 7provided by RGD
Primary source: RGD:61836
See related: EnsemblRapid:ENSRNOG00000016976 AllianceGenome:RGD:61836
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: ClC-7
Summary: Predicted to enable chloride transmembrane transporter activity. Involved in response to pH. Predicted to be located in membrane. Predicted to be part of chloride channel complex. Predicted to be active in lysosomal membrane. Human ortholog(s) of this gene implicated in autosomal dominant osteopetrosis 2 and autosomal recessive osteopetrosis 4. Orthologous to human CLCN7 (chloride voltage-gated channel 7). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Adrenal (RPKM 98.5), Kidney (RPKM 98.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q12

Exon count:: 26

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (14656261..14681632)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (14151758..14177130)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (14492844..14518167)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Chloride channel 7 protects from redox status impairment-induced renal tubular epithelial cell apoptosis by activating autophagy.
Title: Chloride channel 7 protects from redox status impairment-induced renal tubular epithelial cell apoptosis by activating autophagy.
G213R mutation prevents ClC-7 from being correctly targeted to the lysosomal membrane.
Title: The G215R mutation in the Cl-/H+-antiporter ClC-7 found in ADO II osteopetrosis does not abolish function but causes a severe trafficking defect.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables antiporter activity	IEA Inferred from Electronic Annotation more info
enables chloride transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables voltage-gated chloride channel activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in chloride transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in response to pH	IDA Inferred from Direct Assay more info	PubMed
involved_in transepithelial chloride transport	IEA Inferred from Electronic Annotation more info
involved_in transepithelial chloride transport	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of chloride channel complex	IEA Inferred from Electronic Annotation more info
part_of chloride channel complex	ISO Inferred from Sequence Orthology more info
is_active_in intracellular membrane-bounded organelle	IBA Inferred from Biological aspect of Ancestor more info
is_active_in lysosomal membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in lysosomal membrane	IEA Inferred from Electronic Annotation more info
located_in lysosomal membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: H(+)/Cl(-) exchange transporter 7

Names: chloride channel 7 alpha subunit; chloride channel protein 7; chloride channel, voltage-sensitive 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031568.2 → NP_113756.1 H(+)/Cl(-) exchange transporter 7

See identical proteins and their annotated locations for NP_113756.1

Status: PROVISIONAL

Source sequence(s)

Z67744

UniProtKB/Swiss-Prot

P51799

UniProtKB/TrEMBL

A0A8L2UJZ0, A6HCZ9

Related

ENSRNOP00000093984.2, ENSRNOT00000120159.2

Conserved Domains (4) summary

COG0517
Location:736 → 793

CBS; CBS domain [Signal transduction mechanisms]

cd03685
Location:93 → 618

ClC_6_like; ClC-6-like chloride channel proteins. This CD includes ClC-6, ClC-7 and ClC-B, C, D in plants. Proteins in this family are ubiquitous in eukarotes and their functions are unclear. They are expressed in intracellular organelles membranes. This family ...

cd04591
Location:634 → 788

CBS_pair_EriC_assoc_euk_bac; This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the EriC CIC-type chloride channels in eukaryotes and bacteria. These ion channels are proteins with a seemingly simple task of allowing the passive flow of ...

pfam00654
Location:183 → 593

Voltage_CLC; Voltage gated chloride channel

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

14656261..14681632

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017597168.2 → XP_017452657.1 H(+)/Cl(-) exchange transporter 7 isoform X2

UniProtKB/TrEMBL

A0A8I5ZMW4, A0A8L2UJZ0

Related

ENSRNOP00000079343.1, ENSRNOT00000113001.2
XM_039085709.2 → XP_038941637.1 H(+)/Cl(-) exchange transporter 7 isoform X1

Conserved Domains (2) summary

cl02915
Location:1 → 371

Voltage_gated_ClC; CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This ...

cd04591
Location:377 → 541

CBS_pair_voltage-gated_CLC_euk_bac; Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the voltage gated CLC (chloride channel) in eukaryotes and bacteria