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    Adap2 ArfGAP with dual PH domains 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 56826, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Adap2provided by RGD
    Official Full Name
    ArfGAP with dual PH domains 2provided by RGD
    Primary source
    RGD:708487
    See related
    AllianceGenome:RGD:708487
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Centa2
    Summary
    Enables phosphatidylinositol binding activity and phosphatidylinositol-3,4-bisphosphate binding activity. Predicted to be involved in heart development. Located in mitochondrial envelope. Orthologous to human ADAP2 (ArfGAP with dual PH domains 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 106.7), Spleen (RPKM 80.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Adap2 in Genome Data Viewer
    Location:
    10q25
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (65635891..65665019)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (65138006..65166147)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (67494851..67527582)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA43 Neighboring gene NME/NM23 nucleoside diphosphate kinase 1, pseudogene 3 Neighboring gene transfer RNA alanine (anticodon CGC) Neighboring gene uncharacterized LOC134480832 Neighboring gene ring finger protein 135

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of gene structure and subcellular localization of human centaurin alpha 2, and p42IP4, a family of two highly homologous, Ins 1,3,4,5-P4-/PtdIns 3,4,5-P3-binding, adapter proteins. Hanck T, et al. J Neurochem, 2004 Jan. PMID 14690521
    2. Identification of centaurin-alpha2: a phosphatidylinositide-binding protein present in fat, heart and skeletal muscle. Whitley P, et al. Eur J Cell Biol, 2002 Apr. PMID 12018390
    3. Evidence by expression analysis of candidate genes for congenital heart defects in the NF1 microdeletion interval. Venturin M, et al. Ann Hum Genet, 2005 Sep. PMID 16138909
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Results describe the cloning, expression and characterisation of centaurin-alpha2 from a rat adipocyte cDNA library.
      Title: Identification of centaurin-alpha2: a phosphatidylinositide-binding protein present in fat, heart and skeletal muscle.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 1-phosphatidylinositol binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables inositol 1,3,4,5 tetrakisphosphate binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables inositol 1,3,4,5 tetrakisphosphate binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylinositol bisphosphate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylinositol-3,4,5-trisphosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol-3,4,5-trisphosphate binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphatidylinositol-3,4,5-trisphosphate binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylinositol-3,4-bisphosphate binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphatidylinositol-4,5-bisphosphate binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in heart development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in heart development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in heart development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial envelope IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    arf-GAP with dual PH domain-containing protein 2
    Names
    Centaurin-alpha2 protein
    centaurin-alpha-2
    cnt-a2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_020101.2 → NP_064486.1  arf-GAP with dual PH domain-containing protein 2

      See identical proteins and their annotated locations for NP_064486.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/Swiss-Prot
      Q9JK15
      UniProtKB/TrEMBL
      A6HHA5
      Conserved Domains (4) summary
      cd01251
      Location:254 → 361
      PH2_ADAP; ArfGAP with dual PH domains Pleckstrin homology (PH) domain, repeat 2
      cd13252
      Location:132 → 240
      PH1_ADAP; ArfGAP with dual PH domains Pleckstrin homology (PH) domain, repeat 1
      pfam00169
      Location:257 → 360
      PH; PH domain
      pfam01412
      Location:9 → 122
      ArfGap; Putative GTPase activating protein for Arf

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      65635891..65665019
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063269737.1 → XP_063125807.1  arf-GAP with dual PH domain-containing protein 2 isoform X1

    2. XM_039086713.2 → XP_038942641.1  arf-GAP with dual PH domain-containing protein 2 isoform X2

      UniProtKB/TrEMBL
      D3ZQG5
      Conserved Domains (3) summary
      cd01251
      Location:278 → 385
      PH2_ADAP; ArfGAP with dual PH domains Pleckstrin homology (PH) domain, repeat 2
      cd13252
      Location:156 → 264
      PH1_ADAP; ArfGAP with dual PH domains Pleckstrin homology (PH) domain, repeat 1
      cl28907
      Location:4 → 141
      ArfGap; GTPase-activating protein (GAP) for the ADP ribosylation factors (ARFs)

    3. XM_063269738.1 → XP_063125808.1  arf-GAP with dual PH domain-containing protein 2 isoform X3

    4. XM_063269739.1 → XP_063125809.1  arf-GAP with dual PH domain-containing protein 2 isoform X4

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9JK15.1 GenPept UniProtKB/Swiss-Prot:Q9JK15

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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