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    Cand2 cullin-associated and neddylation-dissociated 2 (putative) [ Rattus norvegicus (Norway rat) ]

    Gene ID: 192226, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cand2provided by RGD
    Official Full Name
    cullin-associated and neddylation-dissociated 2 (putative)provided by RGD
    Primary source
    RGD:620480
    See related
    EnsemblRapid:ENSRNOG00000010473 AllianceGenome:RGD:620480
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Tip120B
    Summary
    Enables TBP-class protein binding activity. Predicted to be involved in SCF complex assembly and protein ubiquitination. Predicted to be located in cytosol. Predicted to be active in nucleus. Orthologous to human CAND2 (cullin associated and neddylation dissociated 2 (putative)). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 221.6), Heart (RPKM 149.6) and 6 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cand2 in Genome Data Viewer
    Location:
    4q42
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (150507659..150535755)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (148835050..148864039)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (147686487..147714593)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA17 Neighboring gene transmembrane protein 40 Neighboring gene transfer RNA alanine (anticodon AGC) 42 Neighboring gene small nucleolar RNA SNORA7 Neighboring gene ribosomal protein L32 Neighboring gene EF-hand calcium binding domain 12

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Transcriptome clarifies mechanisms of lesion genesis versus progression in models of Ccm3 cerebral cavernous malformations. Koskimäki J, et al. Acta Neuropathol Commun, 2019 Aug 19. PMID 31426861, Free PMC Article
    2. NEURL rs6584555 and CAND2 rs4642101 contribute to postoperative atrial fibrillation: a prospective study among Chinese population. Wei T, et al. Oncotarget, 2016 Jul 5. PMID 27203392, Free PMC Article
    3. Genomic Variants in NEURL, GJA1 and CUX2 Significantly Increase Genetic Susceptibility to Atrial Fibrillation. Wang P, et al. Sci Rep, 2018 Feb 19. PMID 29459676, Free PMC Article
    4. Proteolytic targeting of transcriptional regulator TIP120B by a HECT domain E3 ligase. You J, et al. J Biol Chem, 2003 Jun 27. PMID 12692129
    5. TIP120B: a novel TIP120-family protein that is expressed specifically in muscle tissues. Aoki T, et al. Biochem Biophys Res Commun, 1999 Aug 11. PMID 10441524

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables TBP-class protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables TBP-class protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables TBP-class protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in SCF complex assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in SCF complex assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    cullin-associated NEDD8-dissociated protein 2
    Names
    TBP-interacting protein 120B
    TBP-interacting protein Tip120B
    TBP-interacting protein b
    TBP-interacting protein of 120 kDa B
    cullin-associated and neddylation-dissociated protein 2
    p120 CAND2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_181362.2 → NP_852027.2  cullin-associated NEDD8-dissociated protein 2

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/TrEMBL
      A6IKZ4, A6IKZ6, D4AAI5
      Related
      ENSRNOP00000102500.1, ENSRNOT00000134792.1
      Conserved Domains (3) summary
      sd00044
      Location:864 → 886
      HEAT; HEAT repeat [structural motif]
      pfam08623
      Location:1057 → 1187
      TIP120; TATA-binding protein interacting (TIP20)
      pfam13513
      Location:150 → 202
      HEAT_EZ; HEAT-like repeat

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      150507659..150535755
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006237004.4 → XP_006237066.1  cullin-associated NEDD8-dissociated protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006237066.1

      UniProtKB/Swiss-Prot
      Q9R0L3, Q9R0L4, Q9R0L5
      UniProtKB/TrEMBL
      A0A0G2K139, A6IKZ5, G3V7E8
      Related
      ENSRNOP00000014207.4, ENSRNOT00000014207.6
      Conserved Domains (3) summary
      pfam08623
      Location:1095 → 1244
      TIP120; TATA-binding protein interacting (TIP20)
      pfam13513
      Location:188 → 240
      HEAT_EZ; HEAT-like repeat
      sd00044
      Location:902 → 924
      HEAT; HEAT repeat [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9R0L4.1 GenPept UniProtKB/Swiss-Prot:Q9R0L4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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