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    Ruvbl2 RuvB-like AAA ATPase 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 292907, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ruvbl2provided by RGD
    Official Full Name
    RuvB-like AAA ATPase 2provided by RGD
    Primary source
    RGD:1306509
    See related
    EnsemblRapid:ENSRNOG00000020793 AllianceGenome:RGD:1306509
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable several functions, including adenyl ribonucleotide binding activity; double-stranded DNA binding activity; and general transcription initiation factor binding activity. Predicted to be involved in several processes, including box C/D snoRNP assembly; cellular response to estradiol stimulus; and regulation of nucleobase-containing compound metabolic process. Predicted to act upstream of or within telomerase RNA localization to Cajal body. Predicted to be located in several cellular components, including centrosome; euchromatin; and nucleoplasm. Predicted to be part of several cellular components, including MLL1 complex; R2TP complex; and chromatin. Orthologous to human RUVBL2 (RuvB like AAA ATPase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 166.7), Testes (RPKM 136.9) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Ruvbl2 in Genome Data Viewer
    Location:
    1q22
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (105038487..105051851, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (95902014..95915247, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (101413766..101426970, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene neurotrophin 4 Neighboring gene stabilizer of axonemal microtubules 3 Neighboring gene luteinizing hormone subunit beta Neighboring gene glycogen synthase 1 Neighboring gene ferritin light chain 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ADP binding  
    enables ATP binding  
    enables ATP hydrolysis activity  
    enables ATPase binding  
    enables DNA helicase activity  
    enables DNA helicase activity  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding  
    enables RNA polymerase II core promoter sequence-specific DNA binding  
    enables TBP-class protein binding  
    enables TFIID-class transcription factor complex binding  
    enables beta-catenin binding  
    enables chromatin DNA binding  
    enables double-stranded DNA helicase activity  
    enables forked DNA-dependent helicase activity  
    enables four-way junction helicase activity  
    enables identical protein binding  
    enables promoter-enhancer loop anchoring activity  
    enables protein homodimerization activity  
    enables single-stranded 3'-5' DNA helicase activity  
    enables transcription corepressor activity  
    Items 1 - 25 of 26
    Process Evidence Code Pubs
    involved_in DNA duplex unwinding  
    involved_in DNA recombination  
    involved_in DNA repair  
    involved_in biological_process  
    involved_in box C/D snoRNP assembly  
    involved_in cellular response to UV  
    involved_in cellular response to estradiol stimulus  
    involved_in chromatin remodeling  
    involved_in chromatin remodeling  
    involved_in establishment of protein localization to chromatin  
    involved_in negative regulation of DNA-templated transcription  
    involved_in negative regulation of canonical Wnt signaling pathway  
    involved_in positive regulation of DNA repair  
    involved_in positive regulation of DNA-templated transcription  
    involved_in positive regulation of double-strand break repair via homologous recombination  
    involved_in positive regulation of telomere maintenance in response to DNA damage  
    involved_in positive regulation of transcription by RNA polymerase II  
    involved_in regulation of DNA repair  
    involved_in regulation of DNA replication  
    involved_in regulation of DNA strand elongation  
    involved_in regulation of cell cycle  
    involved_in regulation of chromosome organization  
    involved_in regulation of embryonic development  
    involved_in regulation of transcription by RNA polymerase II  
    acts_upstream_of_or_within telomerase RNA localization to Cajal body PubMed 
    involved_in telomere maintenance  
    Items 1 - 25 of 26
    Items 1 - 20 of 22
    Component Evidence Code Pubs
    part_of Ino80 complex  
    part_of Ino80 complex  
    part_of MLL1 complex  
    part_of NuA4 histone acetyltransferase complex  
    part_of NuA4 histone acetyltransferase complex  
    part_of R2TP complex  
    part_of R2TP complex  
    part_of RPAP3/R2TP/prefoldin-like complex  
    part_of Swr1 complex  
    part_of Swr1 complex  
    located_in centrosome  
    located_in centrosome  
    located_in cytoplasm  
    located_in cytosol  
    located_in cytosol  
    located_in dynein axonemal particle  
    located_in euchromatin  
    located_in nucleoplasm  
    part_of nucleosome  
    located_in nucleus  
    part_of protein folding chaperone complex  
    part_of ribonucleoprotein complex  
    Items 1 - 20 of 22

    General protein information

    Preferred Names
    ruvB-like 2
    Names
    RuvB-like protein 2
    NP_001020576.2
    XP_038960974.1
    XP_063140282.1
    XP_063140289.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001025405.3NP_001020576.2  ruvB-like 2

      See identical proteins and their annotated locations for NP_001020576.2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A6JB30, Q4QQS4
      Related
      ENSRNOP00000028217.6, ENSRNOT00000028217.8
      Conserved Domains (1) summary
      COG1224
      Location:15451
      TIP49; DNA helicase TIP49, TBP-interacting protein [Transcription]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      105038487..105051851 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063284219.1XP_063140289.1  ruvB-like 2 isoform X2

      UniProtKB/TrEMBL
      Q4QQS4
    2. XM_039105046.2XP_038960974.1  ruvB-like 2 isoform X3

      UniProtKB/TrEMBL
      G3V8T5, Q4QQS4
      Related
      ENSRNOP00000079618.2, ENSRNOT00000097056.2
      Conserved Domains (1) summary
      COG1224
      Location:18454
      TIP49; DNA helicase TIP49, TBP-interacting protein [Transcription]
    3. XM_063284212.1XP_063140282.1  ruvB-like 2 isoform X1

      UniProtKB/TrEMBL
      Q4QQS4
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