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    Wdr18 WD repeat domain 18 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 314617, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Wdr18provided by RGD
    Official Full Name
    WD repeat domain 18provided by RGD
    Primary source
    RGD:1310646
    See related
    EnsemblRapid:ENSRNOG00000012379 AllianceGenome:RGD:1310646
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in DNA-templated DNA replication and rRNA processing. Predicted to be located in dynein axonemal particle and nucleoplasm. Predicted to be part of nuclear pre-replicative complex and rixosome complex. Orthologous to human WDR18 (WD repeat domain 18). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 142.3), Heart (RPKM 111.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Wdr18 in Genome Data Viewer
    Location:
    7q11
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (10390879..10398998, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (9740245..9748041, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (12561318..12569120, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene transmembrane protein 259 Neighboring gene glutamate ionotropic receptor NMDA type subunit 3B Neighboring gene AT-rich interaction domain 3A Neighboring gene KISS1 receptor

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Clone Names

    • MGC124826

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in DNA-templated DNA replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in rRNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in rRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in dynein axonemal particle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in dynein axonemal particle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of nuclear pre-replicative complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of rixosome complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    WD repeat-containing protein 18

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039027.1 → NP_001034116.1  WD repeat-containing protein 18

      See identical proteins and their annotated locations for NP_001034116.1

      Status: PROVISIONAL

      Source sequence(s)
      BC099828
      UniProtKB/Swiss-Prot
      Q499N3
      UniProtKB/TrEMBL
      A6K8U2, F1LR39
      Related
      ENSRNOP00000016733.5, ENSRNOT00000016733.10
      Conserved Domains (3) summary
      sd00039
      Location:84 → 119
      7WD40; WD40 repeat [structural motif]
      cl10011
      Location:212 → 430
      Periplasmic_Binding_Protein_type1; Type 1 periplasmic binding fold superfamily
      cl29593
      Location:22 → 297
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      10390879..10398998 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039078977.2 → XP_038934905.2  WD repeat-containing protein 18 isoform X1

    2. XM_006240906.3 → XP_006240968.1  WD repeat-containing protein 18 isoform X3

      UniProtKB/TrEMBL
      A6K8U2, F1LR39
      Conserved Domains (3) summary
      sd00039
      Location:7 → 42
      7WD40; WD40 repeat [structural motif]
      cl10011
      Location:135 → 353
      Periplasmic_Binding_Protein_type1; Type 1 periplasmic binding fold superfamily
      cl29593
      Location:4 → 244
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    3. XM_063263411.1 → XP_063119481.1  WD repeat-containing protein 18 isoform X2

    4. XM_063263412.1 → XP_063119482.1  WD repeat-containing protein 18 isoform X4

      UniProtKB/TrEMBL
      A0A8I6AMB6, A6K8U3
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q499N3.1 GenPept UniProtKB/Swiss-Prot:Q499N3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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