Ap3b2 adaptor related protein complex 3 subunit beta 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ap3b2provided by RGD
Official Full Name: adaptor related protein complex 3 subunit beta 2provided by RGD
Primary source: RGD:1308950
See related: EnsemblRapid:ENSRNOG00000019249 AllianceGenome:RGD:1308950
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to be involved in anterograde synaptic vesicle transport and synaptic vesicle endocytosis. Predicted to be active in presynapse. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 48. Orthologous to human AP3B2 (adaptor related protein complex 3 subunit beta 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 197.1), Uterus (RPKM 19.9) and 1 other tissue See more
Orthologs: human mouse all
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Genomic context

Location:: 1q31

Exon count:: 27

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (144821819..144854533, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (135412580..135445191, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (143284041..143315846, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
involved_in anterograde axonal transport	ISO Inferred from Sequence Orthology more info
involved_in anterograde synaptic vesicle transport	ISO Inferred from Sequence Orthology more info
involved_in synaptic vesicle endocytosis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in presynapse	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: AP-3 complex subunit beta-2

Names: adaptor-related protein complex 3, beta 2 subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001107532.2 → NP_001101002.2 AP-3 complex subunit beta-2

Status: VALIDATED

Source sequence(s)

FQ085944, JAXUCZ010000001

UniProtKB/TrEMBL

A6JCF9

Related

ENSRNOP00000107834.1, ENSRNOT00000026030.9

Conserved Domains (3) summary

sd00044
Location:111 → 139

HEAT; HEAT repeat [structural motif]

pfam01602
Location:34 → 590

Adaptin_N; Adaptin N terminal region

pfam14796
Location:804 → 947

AP3B1_C; Clathrin-adaptor complex-3 beta-1 subunit C-terminal