Tagln3 transgelin 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Tagln3provided by RGD
Full Name: transgelin 3provided by RGD
Primary source: RGD:69301
See related: EnsemblRapid:ENSRNOG00000064186 AllianceGenome:RGD:69301
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Np22; Np25
Summary: Predicted to enable actin filament binding activity. Predicted to be involved in actin filament organization. Predicted to act upstream of or within negative regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be active in actin cytoskeleton and synapse. Orthologous to human TAGLN3 (transgelin 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward (RPKM 974.7) See more
Orthologs: human mouse all
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Genomic context

Location:: 11q21

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	11	NC_086029.1 (68562482..68576058)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	11	NC_051346.1 (55099887..55113457)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	11	NC_005110.4 (60072983..60086552)

Chromosome 11 - NC_086029.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

NP22 may play a role in mediating the molecular events governing development of the neuronal architecture. Furthermore, its sustained expression in postnatal brain implies a function in the maintenance of neuronal morphology.
Title: The novel cytoskeleton-associated protein Neuronal protein 22: elevated expression in the developing rat brain.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in actin filament organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in actin cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in synapse	IEA Inferred from Electronic Annotation more info
is_active_in synapse	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: transgelin-3

Names: neuronal protein 22; neuronal protein Np25

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001035236.1 → NP_001030313.1 transgelin-3

See identical proteins and their annotated locations for NP_001030313.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.

Source sequence(s)

AF459788, M84725

UniProtKB/Swiss-Prot

P37805, Q09025, Q8VHH3

UniProtKB/TrEMBL

A0A8L2UHL4, A6IQX9

Related

ENSRNOP00000072985.1, ENSRNOT00000090230.3

Conserved Domains (2) summary

pfam00402
Location:174 → 198

Calponin; Calponin family repeat

cd21281
Location:23 → 141

CH_TAGLN3; calponin homology (CH) domain found in transgelin-3
NM_031676.2 → NP_113864.2 transgelin-3

See identical proteins and their annotated locations for NP_113864.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.

Source sequence(s)

AF459788, CB795348, M84725

UniProtKB/Swiss-Prot

P37805, Q09025, Q8VHH3

UniProtKB/TrEMBL

A0A8L2UHL4, A6IQX9

Conserved Domains (2) summary

pfam00402
Location:174 → 198

Calponin; Calponin family repeat

cd21281
Location:23 → 141

CH_TAGLN3; calponin homology (CH) domain found in transgelin-3

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086029.1 Reference GRCr8

Range

68562482..68576058

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039088610.2 → XP_038944538.1 transgelin-3 isoform X1

Conserved Domains (2) summary

pfam00402
Location:90 → 114

Calponin; Calponin family repeat

cl00030
Location:1 → 70

CH_SF; calponin homology (CH) domain superfamily
XM_039088609.2 → XP_038944537.1 transgelin-3 isoform X1

Conserved Domains (2) summary

pfam00402
Location:90 → 114

Calponin; Calponin family repeat

cl00030
Location:1 → 70

CH_SF; calponin homology (CH) domain superfamily