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    Naa50 N(alpha)-acetyltransferase 50, NatE catalytic subunit [ Rattus norvegicus (Norway rat) ]

    Gene ID: 288108, updated on 9-Dec-2024

    Summary

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    Symbol
    Naa50provided by RGD
    Full Name
    N(alpha)-acetyltransferase 50, NatE catalytic subunitprovided by RGD
    Primary source
    RGD:1310944
    See related
    EnsemblRapid:ENSRNOG00000039017 AllianceGenome:RGD:1310944
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Mak3; Nat13
    Summary
    Predicted to enable histone H4 acetyltransferase activity and peptide alpha-N-acetyltransferase activity. Predicted to be involved in N-terminal protein amino acid acetylation; establishment of mitotic sister chromatid cohesion; and mitotic sister chromatid cohesion, centromeric. Predicted to be located in cytosol and nucleolus. Predicted to be part of NatA complex. Orthologous to human NAA50 (N-alpha-acetyltransferase 50, NatE catalytic subunit). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 708.1), Heart (RPKM 227.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Naa50 in Genome Data Viewer
    Location:
    11q21
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (70044281..70066754, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (56538366..56560842, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (61508162..61530830, complement)

    Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene SID1 transmembrane family, member 1 Neighboring gene U2 spliceosomal RNA Neighboring gene upstream transcription factor family member 3 Neighboring gene uncharacterized LOC120095658 Neighboring gene ATPase H+ transporting V1 subunit A Neighboring gene uncharacterized LOC134481070 Neighboring gene GRAM domain containing 1C

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Human Naa50 Protein Displays Broad Substrate Specificity for Amino-terminal Acetylation: DETAILED STRUCTURAL AND BIOCHEMICAL ANALYSIS USING TETRAPEPTIDE LIBRARY. Reddi R, et al. J Biol Chem, 2016 Sep 23. PMID 27484799, Free PMC Article
    2. Human protein N-terminal acetyltransferase hNaa50p (hNAT5/hSAN) follows ordered sequential catalytic mechanism: combined kinetic and NMR study. Evjenth RH, et al. J Biol Chem, 2012 Mar 23. PMID 22311970, Free PMC Article
    3. Structure of a ternary Naa50p (NAT5/SAN) N-terminal acetyltransferase complex reveals the molecular basis for substrate-specific acetylation. Liszczak G, et al. J Biol Chem, 2011 Oct 21. PMID 21900231, Free PMC Article
    4. Human Naa50p (Nat5/San) displays both protein N alpha- and N epsilon-acetyltransferase activity. Evjenth R, et al. J Biol Chem, 2009 Nov 6. PMID 19744929, Free PMC Article
    5. The acetyltransferase activity of San stabilizes the mitotic cohesin at the centromeres in a shugoshin-independent manner. Hou F, et al. J Cell Biol, 2007 May 21. PMID 17502424, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC189357

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables histone H4 acetyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables peptide alpha-N-acetyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables peptide-lysine-N-acetyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in N-terminal protein amino acid acetylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in establishment of mitotic sister chromatid cohesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitotic sister chromatid cohesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic sister chromatid cohesion, centromeric ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of NatA complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of NatA complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    N-alpha-acetyltransferase 50
    Names
    N-acetyltransferase 13
    N-alpha-acetyltransferase 50-like
    NP_001099351.1
    NP_001296733.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001105881.4 → NP_001099351.1  N-alpha-acetyltransferase 50 isoform 2

      See identical proteins and their annotated locations for NP_001099351.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      JAXUCZ010000011
      UniProtKB/TrEMBL
      A0A8I6G5M7, A6IR14, D4A5Y6
      Related
      ENSRNOP00000061273.1, ENSRNOT00000068345.5
      Conserved Domains (1) summary
      COG0456
      Location:9 → 144
      RimI; Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis]

    2. NM_001309804.1 → NP_001296733.1  N-alpha-acetyltransferase 50 isoform 1

      See identical proteins and their annotated locations for NP_001296733.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      BC169000
      UniProtKB/TrEMBL
      A0A8I6G5M7, B5DFB7, F1M272
      Conserved Domains (1) summary
      COG0456
      Location:10 → 145
      RimI; Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086029.1 Reference GRCr8

      Range
      70044281..70066754 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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