Amigo1 adhesion molecule with Ig like domain 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Amigo1provided by RGD
Official Full Name: adhesion molecule with Ig like domain 1provided by RGD
Primary source: RGD:1303079
See related: EnsemblRapid:ENSRNOG00000045665 AllianceGenome:RGD:1303079
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Amigo
Summary: Predicted to enable potassium channel regulator activity. Involved in several processes, including axon development; cellular response to L-glutamate; and positive regulation of cell projection organization. Located in neuronal cell body and pericellular basket. Orthologous to human AMIGO1 (adhesion molecule with Ig like domain 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 131.1), Heart (RPKM 80.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q34

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (198511285..198516744)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (195823138..195828593)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (210977125..210982582)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data show that AMIGO is a glycosylated protein widely expressed in the central nervous system (CNS), and can be found in neurons, astrocytes as well as oligodendrocytes.
Title: AMIGO is expressed in multiple brain cell types and may regulate dendritic growth and neuronal survival.
AMIGO is a function-modulating auxiliary subunit for Kv2.1.
Title: AMIGO is an auxiliary subunit of the Kv2.1 potassium channel.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables potassium channel regulator activity	ISO Inferred from Sequence Orthology more info
enables potassium channel regulator activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in axonal fasciculation	IDA Inferred from Direct Assay more info	PubMed
involved_in axonogenesis	IDA Inferred from Direct Assay more info	PubMed
involved_in brain development	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell adhesion	TAS Traceable Author Statement more info	PubMed
involved_in cellular response to L-glutamate	IDA Inferred from Direct Assay more info	PubMed
involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	IBA Inferred from Biological aspect of Ancestor more info
involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	IPI Inferred from Physical Interaction more info	PubMed
involved_in homophilic cell adhesion via plasma membrane adhesion molecules	IPI Inferred from Physical Interaction more info	PubMed
involved_in myelination	IEP Inferred from Expression Pattern more info	PubMed
involved_in neuron projection fasciculation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of axonogenesis	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of neuron projection development	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of potassium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of potassium ion transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of synapse assembly	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of synapse assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of voltage-gated potassium channel activity	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in dendrite	ISS Inferred from Sequence or Structural Similarity more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body membrane	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in pericellular basket	IDA Inferred from Direct Assay more info	PubMed
located_in perikaryon	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	NAS Non-traceable Author Statement more info	PubMed
part_of voltage-gated potassium channel complex	ISO Inferred from Sequence Orthology more info
part_of voltage-gated potassium channel complex	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: amphoterin-induced protein 1

Names: AMIGO-1; alivin-2; amphoretin-induced gene and ORF; transmembrane protein AMIGO

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001412551.1 → NP_001399480.1 amphoterin-induced protein 1 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000002

UniProtKB/Swiss-Prot

Q80ZD7

UniProtKB/TrEMBL

A6HUY4

Related

ENSRNOP00000066608.1, ENSRNOT00000074725.3
NM_206881.1 → NP_996764.1 amphoterin-induced protein 1 precursor

See identical proteins and their annotated locations for NP_996764.1

Status: PROVISIONAL

Source sequence(s)

AY237729

UniProtKB/Swiss-Prot

Q80ZD7

UniProtKB/TrEMBL

A6HUY4

Conserved Domains (4) summary

smart00410
Location:279 → 358

IG_like; Immunoglobulin like

COG4886
Location:53 → 242

LRR; Leucine-rich repeat (LRR) protein [Transcription]

sd00033
Location:44 → 64

LRR_RI; leucine-rich repeat [structural motif]

cd00096
Location:285 → 296

Ig; Ig strand B [structural motif]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086020.1 Reference GRCr8

Range

198511285..198516744

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063281658.1 → XP_063137728.1 amphoterin-induced protein 1 isoform X1

UniProtKB/Swiss-Prot

Q80ZD7

UniProtKB/TrEMBL

A6HUY4

Related

ENSRNOP00000109871.1, ENSRNOT00000156175.1
XM_006233140.4 → XP_006233202.1 amphoterin-induced protein 1 isoform X1

See identical proteins and their annotated locations for XP_006233202.1

UniProtKB/Swiss-Prot

Q80ZD7

UniProtKB/TrEMBL

A6HUY4

Conserved Domains (4) summary

smart00410
Location:279 → 358

IG_like; Immunoglobulin like

COG4886
Location:53 → 242

LRR; Leucine-rich repeat (LRR) protein [Transcription]

sd00033
Location:44 → 64

LRR_RI; leucine-rich repeat [structural motif]

cd00096
Location:285 → 296

Ig; Ig strand B [structural motif]