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    Shc3 SHC adaptor protein 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 114858, updated on 4-Jan-2025

    Summary

    Official Symbol
    Shc3provided by RGD
    Official Full Name
    SHC adaptor protein 3provided by RGD
    Primary source
    RGD:69348
    See related
    EnsemblRapid:ENSRNOG00000014366 AllianceGenome:RGD:69348
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    ShcC
    Summary
    Predicted to enable phosphotyrosine residue binding activity and receptor tyrosine kinase binding activity. Predicted to be involved in cell surface receptor protein tyrosine kinase signaling pathway. Predicted to act upstream of or within glutamatergic synaptic transmission and learning or memory. Predicted to be located in cytosol. Predicted to be active in plasma membrane. Orthologous to human SHC3 (SHC adaptor protein 3). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in Brain (RPKM 88.8), Adrenal (RPKM 22.8) and 2 other tissues See more
    Orthologs
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    Genomic context

    See Shc3 in Genome Data Viewer
    Location:
    17p14
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (13803980..13924433)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (13652247..13772710)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (13670520..13791043)

    Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene SECIS binding protein 2 Neighboring gene small nucleolar RNA SNORA2/SNORA34 family Neighboring gene CDC28 protein kinase regulatory subunit 2 Neighboring gene uncharacterized LOC102556322 Neighboring gene sphingosine-1-phosphate receptor 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    located_in cytosol  
    is_active_in plasma membrane  
    located_in plasma membrane  
    located_in synapse  

    General protein information

    Preferred Names
    SHC-transforming protein 3
    Names
    N-Shc
    SH2 domain protein C3
    SHC (Src homology 2 domain containing) transforming protein 3
    SHC-transforming protein C
    neuronal Shc
    src homology 2 domain-containing transforming protein C3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001105743.1NP_001099213.1  SHC-transforming protein 3

      Status: PROVISIONAL

      Source sequence(s)
      CH473977
      UniProtKB/Swiss-Prot
      O70143
      UniProtKB/TrEMBL
      A6J6U1, G3V7V0
      Related
      ENSRNOP00000019442.2, ENSRNOT00000019442.5
      Conserved Domains (2) summary
      cd09925
      Location:492594
      SH2_SHC; Src homology 2 (SH2) domain found in SH2 adaptor protein C (SHC)
      cd01209
      Location:139310
      PTB_Shc; Shc-like phosphotyrosine-binding (PTB) domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086035.1 Reference GRCr8

      Range
      13803980..13924433
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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