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    Parg poly (ADP-ribose) glycohydrolase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 83507, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pargprovided by RGD
    Official Full Name
    poly (ADP-ribose) glycohydrolaseprovided by RGD
    Primary source
    RGD:620387
    See related
    EnsemblRapid:ENSRNOG00000019978 AllianceGenome:RGD:620387
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables chromatin binding activity and poly(ADP-ribose) glycohydrolase activity. Involved in positive regulation of DNA repair. Located in chromatin. Used to study brain infarction. Biomarker of borna disease. Orthologous to human PARG (poly(ADP-ribose) glycohydrolase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 282.5), Adrenal (RPKM 216.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Parg in Genome Data Viewer
    Location:
    16p16
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (7442696..7550585)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (7436429..7544276)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (8350168..8457999)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene poly (ADP-ribose) glycohydrolase like 1 Neighboring gene nuclear receptor coactivator 4 Neighboring gene small nucleolar RNA SNORA74 Neighboring gene translocase of inner mitochondrial membrane 23 Neighboring gene uncharacterized LOC134482454 Neighboring gene uncharacterized LOC102550503 Neighboring gene oxoglutarate dehydrogenase L

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Structure of mammalian poly(ADP-ribose) glycohydrolase reveals a flexible tyrosine clasp as a substrate-binding element. Kim IK, et al. Nat Struct Mol Biol, 2012 May 20. PMID 22609859, Free PMC Article
    2. Active poly(ADPribose) metabolism in DNAase- and salt-resistant rat testis chromatin with high transcriptional activity/competence. Mennella MR, et al. J Cell Biochem, 2003 Jul 1. PMID 12858335
    3. Post-treatment with a novel PARG inhibitor reduces infarct in cerebral ischemia in the rat. Lu XC, et al. Brain Res, 2003 Jul 18. PMID 12834903
    4. Isolation and cloning of rat poly(ADP-ribose) glycohydrolase: presence of a potential nuclear export signal conserved in mammalian orthologs. Shimokawa T, et al. J Biochem, 1999 Oct. PMID 10502684
    5. Poly(ADPribosyl)ation system in rat germinal cells at different stages of differentiation. Quesada P, et al. Exp Cell Res, 1996 Jul 10. PMID 8660954

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The study reports the crystal structures of Parg and its complex with a substrate mimic that reveal an open substrate-binding site and a unique 'tyrosine clasp' enabling endoglycosidic cleavage of branched PAR chains.
      Title: Structure of mammalian poly(ADP-ribose) glycohydrolase reveals a flexible tyrosine clasp as a substrate-binding element.
    2. PARG is expressed in the nuclear fraction of primary spermatocytes and in the post-nuclear fraction of round spermatids
      Title: Poly(ADPR) polymerase-1 and poly(ADPR) glycohydrolase level and distribution in differentiating rat germinal cells.
    3. poly(ADP-ribose)polymerase-1 and -2 and poly(ADP-ribose)glycohydrolase have key roles in germinal cells as key proteins in processes that sense and repair DNA damage as well as in the commitment to apoptosis following prolonged oxidative stress
      Title: Dual role for poly(ADP-ribose)polymerase-1 and -2 and poly(ADP-ribose)glycohydrolase as DNA-repair and pro-apoptotic factors in rat germinal cells exposed to nitric oxide donors.
    4. results suggest that poly (ADP-ribose) glycohydrolase(PARG) activity modulates the inflammatory response in ischemia/reperfusion and participates in end (target) organ damage under these conditions
      Title: PARG activity mediates intestinal injury induced by splanchnic artery occlusion and reperfusion.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables poly(ADP-ribose) glycohydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables poly(ADP-ribose) glycohydrolase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables poly(ADP-ribose) glycohydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables poly(ADP-ribose) glycohydrolase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in ATP generation from poly-ADP-D-ribose IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ATP generation from poly-ADP-D-ribose IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ATP generation from poly-ADP-D-ribose ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ATP generation from poly-ADP-D-ribose ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within DNA damage response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within detection of bacterium ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in nucleotide-sugar metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of DNA repair IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in chromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear body IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    poly(ADP-ribose) glycohydrolase
    NP_112629.2
    XP_006252731.1
    XP_017455747.1
    XP_038950789.1
    XP_038950791.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031339.2 → NP_112629.2  poly(ADP-ribose) glycohydrolase

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000016
      UniProtKB/Swiss-Prot
      Q9QYM2
      UniProtKB/TrEMBL
      A6KFW3, G3V8M8
      Related
      ENSRNOP00000089571.2, ENSRNOT00000093772.2
      Conserved Domains (2) summary
      pfam05028
      Location:577 → 902
      PARG_cat; Poly (ADP-ribose) glycohydrolase (PARG)
      NF033609
      Location:181 → 398
      MSCRAMM_ClfA; MSCRAMM family adhesin clumping factor ClfA

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      7442696..7550585
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017600258.3 → XP_017455747.1  poly(ADP-ribose) glycohydrolase isoform X2

      UniProtKB/Swiss-Prot
      Q9QYM2
      UniProtKB/TrEMBL
      A6KFW4
      Conserved Domains (2) summary
      pfam01439
      Location:145 → 162
      Metallothio_2; Metallothionein
      pfam05028
      Location:494 → 822
      PARG_cat; Poly (ADP-ribose) glycohydrolase (PARG)

    2. XM_039094861.2 → XP_038950789.1  poly(ADP-ribose) glycohydrolase isoform X1

      UniProtKB/Swiss-Prot
      Q9QYM2
      Related
      ENSRNOP00000110536.1, ENSRNOT00000153712.1
      Conserved Domains (2) summary
      pfam05028
      Location:569 → 871
      PARG_cat; Poly (ADP-ribose) glycohydrolase (PARG)
      NF033609
      Location:181 → 398
      MSCRAMM_ClfA; MSCRAMM family adhesin clumping factor ClfA

    3. XM_039094863.2 → XP_038950791.1  poly(ADP-ribose) glycohydrolase isoform X4

      Conserved Domains (1) summary
      NF033609
      Location:181 → 398
      MSCRAMM_ClfA; MSCRAMM family adhesin clumping factor ClfA

    4. XM_006252669.3 → XP_006252731.1  poly(ADP-ribose) glycohydrolase isoform X3

      UniProtKB/Swiss-Prot
      Q9QYM2
      Related
      ENSRNOP00000027071.5, ENSRNOT00000027071.6
      Conserved Domains (2) summary
      pfam01439
      Location:122 → 139
      Metallothio_2; Metallothionein
      pfam05028
      Location:471 → 799
      PARG_cat; Poly (ADP-ribose) glycohydrolase (PARG)

    RNA

    1. XR_005494674.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9QYM2.1 GenPept UniProtKB/Swiss-Prot:Q9QYM2

    Gene LinkOut

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