Eif3k eukaryotic translation initiation factor 3, subunit K [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Eif3kprovided by RGD
Official Full Name: eukaryotic translation initiation factor 3, subunit Kprovided by RGD
Primary source: RGD:1309221
See related: EnsemblRapid:ENSRNOG00000020495 AllianceGenome:RGD:1309221
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Eif3s12; PLAC-24
Summary: Predicted to enable RNA binding activity and ribosome binding activity. Predicted to contribute to translation initiation factor activity. Predicted to be involved in translational initiation. Predicted to be located in cytosol. Predicted to be part of eukaryotic translation initiation factor 3 complex. Orthologous to human EIF3K (eukaryotic translation initiation factor 3 subunit K). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Heart (RPKM 516.6), Thymus (RPKM 505.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q21

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (93387628..93397551, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (84260127..84270051, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (87927142..87937033, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These observations suggest that PLAC-24 may play a role in the transport and the stabilisation of newly synthesised 5-HT(7) receptor towards the plasma membrane.
Title: Novel interaction between the human 5-HT7 receptor isoforms and PLAC-24/eIF3k.
identification of a novel 24-kDa protein (Plac-24) that binds directly to dynein intermediate chain.
Title: PLAC-24 is a cytoplasmic dynein-binding protein that is recruited to sites of cell-cell contact.

Submit: New GeneRIF Correction

General gene information

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Markers

RH91438 (e-PCR)
- UniSTS:85530

RH131932 (e-PCR)
- UniSTS:215215

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables ribosome binding	IEA Inferred from Electronic Annotation more info
contributes_to translation initiation factor activity	IBA Inferred from Biological aspect of Ancestor more info
contributes_to translation initiation factor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in formation of cytoplasmic translation initiation complex	IEA Inferred from Electronic Annotation more info
involved_in regulation of translational initiation	IEA Inferred from Electronic Annotation more info
involved_in translational initiation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
part_of eukaryotic 43S preinitiation complex	IEA Inferred from Electronic Annotation more info
part_of eukaryotic 48S preinitiation complex	IEA Inferred from Electronic Annotation more info
part_of eukaryotic translation initiation factor 3 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of eukaryotic translation initiation factor 3 complex	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: eukaryotic translation initiation factor 3 subunit K

Names: eukaryotic translation initiation factor 3, subunit 12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001398703.1 → NP_001385632.1 eukaryotic translation initiation factor 3 subunit K

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/TrEMBL

A0A8I5ZX76, A0A8I6AFY5, A6J9M3

Related

ENSRNOP00000083732.1, ENSRNOT00000118913.2

Conserved Domains (1) summary

pfam10075
Location:61 → 189

CSN8_PSD8_EIF3K; CSN8/PSMD8/EIF3K family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

93387628..93397551 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063283417.1 → XP_063139487.1 eukaryotic translation initiation factor 3 subunit K isoform X1

UniProtKB/TrEMBL

A0A8I6AIB7

Related

ENSRNOP00000094716.1, ENSRNOT00000112033.2
XM_039104247.2 → XP_038960175.1 eukaryotic translation initiation factor 3 subunit K isoform X2

Conserved Domains (1) summary

cl24019
Location:61 → 118

CSN8_PSD8_EIF3K; CSN8/PSMD8/EIF3K family

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001106242.1: Suppressed sequence

Description

NM_001106242.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.