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    Ctps2 CTP synthase 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 619580, updated on 4-Jan-2025

    Summary

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    Official Symbol
    Ctps2provided by RGD
    Official Full Name
    CTP synthase 2provided by RGD
    Primary source
    RGD:1563369
    See related
    EnsemblRapid:ENSRNOG00000004257 AllianceGenome:RGD:1563369
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable CTP synthase activity and identical protein binding activity. Predicted to be involved in CTP biosynthetic process and pyrimidine nucleobase biosynthetic process. Predicted to be located in mitochondrion. Predicted to be active in cytoophidium and cytoplasm. Orthologous to human CTPS2 (CTP synthase 2). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in Adrenal (RPKM 150.4), Kidney (RPKM 112.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ctps2 in Genome Data Viewer
    Location:
    Xq14
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (35277658..35418505, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (31645873..31786733, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (33383087..33522852, complement)

    Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene high mobility group AT-hook 1 like 1 Neighboring gene interferon-stimulated 20 kDa exonuclease-like 2 pseudogene Neighboring gene coiled-coil domain containing 43, pseudogene 1 Neighboring gene S100 calcium binding protein G Neighboring gene ornithine decarboxylase 1, pseudogene 2 Neighboring gene synapse associated protein 1 Neighboring gene U6 spliceosomal RNA

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Coupled structural transitions enable highly cooperative regulation of human CTPS2 filaments. Lynch EM, et al. Nat Struct Mol Biol, 2020 Jan. PMID 31873303, Free PMC Article
    2. Identification of a cDNA encoding an isoform of human CTP synthetase. van Kuilenburg AB, et al. Biochim Biophys Acta, 2000 Jul 24. PMID 10899599
    3. Regulation of human cytidine triphosphate synthetase 2 by phosphorylation. Kassel KM, et al. J Biol Chem, 2010 Oct 29. PMID 20739275, Free PMC Article
    4. Low cytosine triphosphate synthase 2 expression renders resistance to 5-fluorouracil in colorectal cancer. Tan WL, et al. Cancer Biol Ther, 2011 Mar 15. PMID 21378502
    5. Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context. Morgenstern M, et al. Cell Metab, 2021 Dec 7. PMID 34800366, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables CTP synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables CTP synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in 'de novo' CTP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in CTP biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in glutamine metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in pyrimidine nucleobase biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoophidium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    CTP synthase 2
    Names
    CTP synthase II
    CTP synthetase 2
    UTP--ammonia ligase 2
    cytidine 5'-triphosphate synthase 2
    cytidine triphosphate synthase II
    NP_001030170.1
    XP_006256958.1
    XP_006256959.1
    XP_006256960.1
    XP_006256961.1
    XP_006256962.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001034998.2 → NP_001030170.1  CTP synthase 2

      Status: VALIDATED

      Source sequence(s)
      BC085949, DV724473, JAXUCZ010000021
      UniProtKB/Swiss-Prot
      Q5U2N0, Q5U3X4
      UniProtKB/TrEMBL
      A0A8L2QRH2
      Related
      ENSRNOP00000055810.3, ENSRNOT00000059031.5
      Conserved Domains (3) summary
      cd01746
      Location:299 → 544
      GATase1_CTP_Synthase; Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase
      PLN02327
      Location:1 → 557
      PLN02327; CTP synthase
      pfam06418
      Location:2 → 272
      CTP_synth_N; CTP synthase N-terminus

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086039.1 Reference GRCr8

      Range
      35277658..35418505 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006256900.3 → XP_006256962.1  CTP synthase 2 isoform X1

      UniProtKB/Swiss-Prot
      Q5U2N0, Q5U3X4
      UniProtKB/TrEMBL
      A0A8L2QRH2
      Conserved Domains (3) summary
      cd01746
      Location:299 → 544
      GATase1_CTP_Synthase; Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase
      PLN02327
      Location:1 → 557
      PLN02327; CTP synthase
      pfam06418
      Location:2 → 272
      CTP_synth_N; CTP synthase N-terminus

    2. XM_006256898.4 → XP_006256960.1  CTP synthase 2 isoform X1

      UniProtKB/Swiss-Prot
      Q5U2N0, Q5U3X4
      UniProtKB/TrEMBL
      A0A8L2QRH2
      Conserved Domains (3) summary
      cd01746
      Location:299 → 544
      GATase1_CTP_Synthase; Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase
      PLN02327
      Location:1 → 557
      PLN02327; CTP synthase
      pfam06418
      Location:2 → 272
      CTP_synth_N; CTP synthase N-terminus

    3. XM_006256896.4 → XP_006256958.1  CTP synthase 2 isoform X1

      UniProtKB/Swiss-Prot
      Q5U2N0, Q5U3X4
      UniProtKB/TrEMBL
      A0A8L2QRH2
      Conserved Domains (3) summary
      cd01746
      Location:299 → 544
      GATase1_CTP_Synthase; Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase
      PLN02327
      Location:1 → 557
      PLN02327; CTP synthase
      pfam06418
      Location:2 → 272
      CTP_synth_N; CTP synthase N-terminus

    4. XM_006256897.5 → XP_006256959.1  CTP synthase 2 isoform X1

      UniProtKB/Swiss-Prot
      Q5U2N0, Q5U3X4
      UniProtKB/TrEMBL
      A0A8L2QRH2
      Conserved Domains (3) summary
      cd01746
      Location:299 → 544
      GATase1_CTP_Synthase; Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase
      PLN02327
      Location:1 → 557
      PLN02327; CTP synthase
      pfam06418
      Location:2 → 272
      CTP_synth_N; CTP synthase N-terminus

    5. XM_006256899.5 → XP_006256961.1  CTP synthase 2 isoform X1

      UniProtKB/Swiss-Prot
      Q5U2N0, Q5U3X4
      UniProtKB/TrEMBL
      A0A8L2QRH2
      Conserved Domains (3) summary
      cd01746
      Location:299 → 544
      GATase1_CTP_Synthase; Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase
      PLN02327
      Location:1 → 557
      PLN02327; CTP synthase
      pfam06418
      Location:2 → 272
      CTP_synth_N; CTP synthase N-terminus
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5U2N0.1 GenPept UniProtKB/Swiss-Prot:Q5U2N0

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