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    Daglb diacylglycerol lipase, beta [ Rattus norvegicus (Norway rat) ]

    Gene ID: 304289, updated on 9-Dec-2024

    Summary

    Official Symbol
    Daglbprovided by RGD
    Official Full Name
    diacylglycerol lipase, betaprovided by RGD
    Primary source
    RGD:1310193
    See related
    EnsemblRapid:ENSRNOG00000001079 AllianceGenome:RGD:1310193
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1310193
    Summary
    Predicted to enable monoacylglycerol lipase activity and triacylglycerol lipase activity. Predicted to be involved in several processes, including diacylglycerol catabolic process; positive regulation of triglyceride catabolic process; and unsaturated fatty acid metabolic process. Predicted to act upstream of or within cannabinoid biosynthetic process; monoacylglycerol biosynthetic process; and neuroblast proliferation. Predicted to be located in nucleoplasm. Predicted to be active in plasma membrane. Orthologous to human DAGLB (diacylglycerol lipase beta). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 74.9), Kidney (RPKM 45.1) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Daglb in Genome Data Viewer
    Location:
    12p11
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (16173345..16215777, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (11059732..11102170, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (13113073..13157748, complement)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene small integral membrane protein 10 like 3 Neighboring gene family with sequence similarity 220, member A Neighboring gene Rac family small GTPase 1 Neighboring gene KDEL endoplasmic reticulum protein retention receptor 2 Neighboring gene Grid2 interacting protein

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables lipase activity  
    enables lipase activity  
    enables metal ion binding  
    enables monoacylglycerol lipase activity  
    enables monoacylglycerol lipase activity  
    enables triacylglycerol lipase activity  
    enables triacylglycerol lipase activity  
    enables triacylglycerol lipase activity  
    enables triacylglycerol lipase activity PubMed 
    Items 1 - 25 of 26
    Process Evidence Code Pubs
    involved_in arachidonate metabolic process  
    involved_in arachidonate metabolic process  
    acts_upstream_of arachidonate metabolic process  
    involved_in arachidonate metabolic process  
    involved_in arachidonate metabolic process PubMed 
    involved_in cannabinoid biosynthetic process  
    acts_upstream_of_or_within cannabinoid biosynthetic process  
    involved_in diacylglycerol catabolic process  
    involved_in icosanoid metabolic process  
    involved_in icosanoid metabolic process  
    involved_in lipid catabolic process  
    involved_in monoacylglycerol biosynthetic process  
    acts_upstream_of_or_within monoacylglycerol biosynthetic process  
    involved_in neuroblast proliferation  
    acts_upstream_of_or_within neuroblast proliferation  
    involved_in neurogenesis  
    acts_upstream_of_or_within neurogenesis  
    involved_in positive regulation of triglyceride catabolic process  
    involved_in positive regulation of triglyceride catabolic process  
    involved_in positive regulation of triglyceride catabolic process PubMed 
    involved_in prostaglandin biosynthetic process  
    involved_in prostaglandin biosynthetic process  
    involved_in prostaglandin biosynthetic process  
    involved_in regulation of inflammatory response  
    involved_in regulation of inflammatory response  
    involved_in regulation of inflammatory response  
    Items 1 - 25 of 26
    Component Evidence Code Pubs
    located_in nucleoplasm  
    located_in nucleoplasm  
    is_active_in plasma membrane  
    located_in plasma membrane  
    located_in plasma membrane  
    located_in plasma membrane  

    General protein information

    Preferred Names
    diacylglycerol lipase-beta
    Names
    DAGL-beta
    DGL-beta
    PUFA-specific triacylglycerol lipase
    sn1-specific diacylglycerol lipase beta
    NP_001100590.1
    XP_038945285.1
    XP_038945286.1
    XP_063127326.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107120.1NP_001100590.1  diacylglycerol lipase-beta

      See identical proteins and their annotated locations for NP_001100590.1

      Status: PROVISIONAL

      Source sequence(s)
      CH474012
      UniProtKB/Swiss-Prot
      P0C1S9
      UniProtKB/TrEMBL
      A0A0U1RRW6, A6K1K9
      Related
      ENSRNOP00000075840.2, ENSRNOT00000092292.3
      Conserved Domains (1) summary
      cd00519
      Location:274507
      Lipase_3; Lipase (class 3). Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the process of ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      16173345..16215777 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063271256.1XP_063127326.1  diacylglycerol lipase-beta isoform X3

      UniProtKB/Swiss-Prot
      P0C1S9
    2. XM_039089358.2XP_038945286.1  diacylglycerol lipase-beta isoform X2

      Conserved Domains (1) summary
      cd00519
      Location:1226
      Lipase_3; Lipase (class 3). Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the process of ...
    3. XM_039089357.2XP_038945285.1  diacylglycerol lipase-beta isoform X1

      Conserved Domains (1) summary
      cd00519
      Location:274478
      Lipase_3; Lipase (class 3). Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the process of ...
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