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    Ptpra protein tyrosine phosphatase, receptor type, A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25167, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ptpraprovided by RGD
    Official Full Name
    protein tyrosine phosphatase, receptor type, Aprovided by RGD
    Primary source
    RGD:3450
    See related
    EnsemblRapid:ENSRNOG00000021223 AllianceGenome:RGD:3450
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    LRP
    Summary
    Enables protein tyrosine phosphatase activity. Involved in oligodendrocyte differentiation and positive regulation of oligodendrocyte differentiation. Predicted to be located in focal adhesion and membrane. Predicted to be part of receptor complex. Predicted to be active in Schaffer collateral - CA1 synapse and synaptic membrane. Orthologous to human PTPRA (protein tyrosine phosphatase receptor type A). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 291.6), Heart (RPKM 200.6) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Ptpra in Genome Data Viewer
    Location:
    3q36
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (138103261..138212835)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (117650146..117759744)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (122976066..123084585)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene PC-esterase domain containing 1A Neighboring gene transmembrane 239 Neighboring gene VPS16 core subunit of CORVET and HOPS complexes Neighboring gene uncharacterized LOC134486445 Neighboring gene mitochondrial ribosomal protein S26 Neighboring gene oxytocin/neurophysin I prepropeptide

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Clone Names

    • MGC93561

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in chromatin remodeling  
    involved_in insulin receptor signaling pathway  
    acts_upstream_of_or_within insulin receptor signaling pathway  
    involved_in integrin-mediated signaling pathway  
    involved_in integrin-mediated signaling pathway  
    involved_in integrin-mediated signaling pathway  
    involved_in modulation of chemical synaptic transmission  
    involved_in modulation of chemical synaptic transmission  
    involved_in oligodendrocyte differentiation PubMed 
    involved_in positive regulation of oligodendrocyte differentiation PubMed 
    acts_upstream_of_or_within protein phosphorylation  
    involved_in regulation of focal adhesion assembly  
    involved_in regulation of focal adhesion assembly  
    involved_in regulation of focal adhesion assembly  
    involved_in signal transduction  
    Component Evidence Code Pubs
    located_in Schaffer collateral - CA1 synapse  
    is_active_in Schaffer collateral - CA1 synapse  
    located_in focal adhesion  
    located_in focal adhesion  
    located_in focal adhesion  
    located_in membrane  
    located_in plasma membrane  
    part_of receptor complex  
    part_of receptor complex  
    located_in synaptic membrane  
    is_active_in synaptic membrane  

    General protein information

    Preferred Names
    receptor-type tyrosine-protein phosphatase alpha
    Names
    R-PTP-alpha
    protein tyrosine phosphatase alpha
    NP_036895.2
    XP_006235068.1
    XP_038960268.1
    XP_063139209.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012763.2NP_036895.2  receptor-type tyrosine-protein phosphatase alpha precursor

      See identical proteins and their annotated locations for NP_036895.2

      Status: PROVISIONAL

      Source sequence(s)
      BC081828
      UniProtKB/Swiss-Prot
      Q03348
      UniProtKB/TrEMBL
      F1M833, Q66HJ7
      Related
      ENSRNOP00000109915.1, ENSRNOT00000162829.1
      Conserved Domains (3) summary
      PHA03255
      Location:18169
      PHA03255; BDLF3; Provisional
      smart00194
      Location:526784
      PTPc; Protein tyrosine phosphatase, catalytic domain
      cd00047
      Location:554784
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      138103261..138212835
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006235006.5XP_006235068.1  receptor-type tyrosine-protein phosphatase alpha isoform X1

      See identical proteins and their annotated locations for XP_006235068.1

      UniProtKB/Swiss-Prot
      Q03348
      UniProtKB/TrEMBL
      A0A8J8YBN3
      Related
      ENSRNOP00000103665.1, ENSRNOT00000147780.1
      Conserved Domains (3) summary
      PHA03255
      Location:18177
      PHA03255; BDLF3; Provisional
      cd14621
      Location:217512
      R-PTPc-A-1; catalytic domain of receptor-type tyrosine-protein phosphatase A, repeat 1
      cd14623
      Location:566793
      R-PTPc-A-2; catalytic domain of receptor-type tyrosine-protein phosphatase A, repeat 2
    2. XM_039104340.2XP_038960268.1  receptor-type tyrosine-protein phosphatase alpha isoform X1

      UniProtKB/Swiss-Prot
      Q03348
      UniProtKB/TrEMBL
      A0A8J8YBN3
      Conserved Domains (3) summary
      PHA03255
      Location:18177
      PHA03255; BDLF3; Provisional
      cd14621
      Location:217512
      R-PTPc-A-1; catalytic domain of receptor-type tyrosine-protein phosphatase A, repeat 1
      cd14623
      Location:566793
      R-PTPc-A-2; catalytic domain of receptor-type tyrosine-protein phosphatase A, repeat 2
    3. XM_063283139.1XP_063139209.1  receptor-type tyrosine-protein phosphatase alpha isoform X2

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