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    Cyp2d5 cytochrome P450, family 2, subfamily d, polypeptide 5 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 286963, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cyp2d5provided by RGD
    Official Full Name
    cytochrome P450, family 2, subfamily d, polypeptide 5provided by RGD
    Primary source
    RGD:628630
    See related
    EnsemblRapid:ENSRNOG00000077236 AllianceGenome:RGD:628630
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Cyp2d10
    Summary
    Predicted to enable heme binding activity and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen. Predicted to be involved in arachidonate metabolic process and xenobiotic metabolic process. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in cytoplasm and intracellular membrane-bounded organelle. Human ortholog(s) of this gene implicated in several diseases, including autoimmune hepatitis; extrapyramidal and movement disease; head and neck squamous cell carcinoma; leukemia (multiple); and major depressive disorder. Orthologous to human CYP2D6 (cytochrome P450 family 2 subfamily D member 6) and CYP2D7 (cytochrome P450 family 2 subfamily D member 7 (gene/pseudogene)). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward (RPKM 1419.8) See more
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    Genomic context

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    See Cyp2d5 in Genome Data Viewer
    Location:
    7q34
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (115779981..115784554, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (113899905..113904458, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (123616596..123621102, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene NADH:ubiquinone oxidoreductase subunit A6 Neighboring gene cytochrome P450, family 2, subfamily d, polypeptide 4 Neighboring gene uncharacterized LOC103692951 Neighboring gene cytochrome P450, family 2, subfamily d, polypeptide 1 Neighboring gene cytochrome P450, family 2, subfamily d, polypeptide 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Cytochrome P450CMF cDNA: nucleotide sequence of P450CMF1b. Ishida N, et al. Nucleic Acids Res, 1989 Aug 11. PMID 2771656, Free PMC Article
    2. Four species of cDNAs for cytochrome P450 isozymes immunorelated to P450C-M/F encode for members of P450IID subfamily, increasing the number of members within the subfamily. Ishida N, et al. Biochem Biophys Res Commun, 1988 Oct 31. PMID 3190674
    3. The CYP2D gene subfamily: analysis of the molecular basis of the debrisoquine 4-hydroxylase deficiency in DA rats. Matsunaga E, et al. Biochemistry, 1989 Sep 5. PMID 2819073
    4. The rat P450 IID subfamily: complete sequences of four closely linked genes and evidence that gene conversions maintained sequence homogeneity at the heme-binding region of the cytochrome P450 active site. Matsunaga E, et al. J Mol Evol, 1990 Feb. PMID 2107330
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC108540

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables heme binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monooxygenase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in arachidonate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in xenobiotic metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    cytochrome P450 2D10
    Names
    CYPIID10
    P450-CMF1B
    P450-DB5
    cytochrome P450, family 2, subfamily d, polypeptide 10
    cytochrome P450-CMF1B
    cytochrome P450-DB5
    cytochrome P450CMF1b
    debrisoquine 4-hydroxylase
    NP_775426.1
    XP_038934457.1
    XP_038934458.1
    XP_038934459.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_173304.2 → NP_775426.1  cytochrome P450 2D10

      See identical proteins and their annotated locations for NP_775426.1

      Status: PROVISIONAL

      Source sequence(s)
      J02869
      UniProtKB/Swiss-Prot
      P12939
      UniProtKB/TrEMBL
      F7FD56, Q5I0P9
      Related
      ENSRNOP00000040266.2, ENSRNOT00000046024.5
      Conserved Domains (1) summary
      pfam00067
      Location:37 → 496
      p450; Cytochrome P450

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      115779981..115784554 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039078529.2 → XP_038934457.1  cytochrome P450 2D10 isoform X1

      UniProtKB/TrEMBL
      A0A8I6GJ89, F7FD56, Q5I0P9
      Related
      ENSRNOP00000091804.1, ENSRNOT00000095995.2
      Conserved Domains (1) summary
      cl41757
      Location:68 → 444
      cytochrome_P450; cytochrome P450 (CYP) superfamily

    2. XM_039078530.2 → XP_038934458.1  cytochrome P450 2D10 isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZWE8
      Related
      ENSRNOP00000100990.1, ENSRNOT00000151808.1
      Conserved Domains (1) summary
      cl41757
      Location:68 → 385
      cytochrome_P450; cytochrome P450 (CYP) superfamily

    3. XM_039078531.2 → XP_038934459.1  cytochrome P450 2D10 isoform X3

      Conserved Domains (2) summary
      cl12078
      Location:9 → 97
      p450; Cytochrome P450
      cl41757
      Location:68 → 289
      cytochrome_P450; cytochrome P450 (CYP) superfamily
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P12939.1 GenPept UniProtKB/Swiss-Prot:P12939

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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