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    Dll1 delta like canonical Notch ligand 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 84010, updated on 9-Dec-2024

    Summary

    Official Symbol
    Dll1provided by RGD
    Official Full Name
    delta like canonical Notch ligand 1provided by RGD
    Primary source
    RGD:70949
    See related
    EnsemblRapid:ENSRNOG00000059984 AllianceGenome:RGD:70949
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables Notch binding activity. Involved in clathrin-dependent endocytosis and positive regulation of Notch signaling pathway. Predicted to be located in several cellular components, including adherens junction; apical plasma membrane; and membrane raft. Predicted to be active in plasma membrane. Orthologous to human DLL1 (delta like canonical Notch ligand 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 99.8), Lung (RPKM 56.3) and 8 other tissues See more
    Orthologs
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    Genomic context

    See Dll1 in Genome Data Viewer
    Location:
    1q12
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (64985161..64993274, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (56312062..56320177, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (57318621..57326732, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102550720 Neighboring gene uncharacterized LOC134485093 Neighboring gene ribosomal protein SA, pseudogene 16 Neighboring gene family with sequence similarity 120 member B Neighboring gene uncharacterized LOC102557016 Neighboring gene proteasome 20S subunit beta 1 Neighboring gene TATA box binding protein

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables Notch binding  
    enables Notch binding  
    enables Notch binding PubMed 
    enables Notch binding  
    enables Notch binding PubMed 
    enables Tat protein binding  
    enables Tat protein binding  
    enables calcium ion binding  
    enables protein binding PubMed 
    enables receptor ligand activity  
    enables receptor ligand activity  
    enables scaffold protein binding  
    enables scaffold protein binding  
    Items 1 - 25 of 166
    Process Evidence Code Pubs
    involved_in Notch signaling pathway  
    involved_in Notch signaling pathway  
    involved_in Notch signaling pathway  
    involved_in Notch signaling pathway  
    involved_in Notch signaling pathway PubMed 
    involved_in Notch signaling pathway involved in arterial endothelial cell fate commitment  
    involved_in Notch signaling pathway involved in arterial endothelial cell fate commitment  
    involved_in Notch signaling pathway involved in arterial endothelial cell fate commitment  
    involved_in astrocyte development  
    involved_in astrocyte development  
    involved_in astrocyte development  
    involved_in auditory receptor cell fate commitment PubMed 
    involved_in cell fate determination PubMed 
    acts_upstream_of_or_within cell-cell signaling  
    involved_in cerebellar Purkinje cell layer structural organization  
    involved_in cerebellar Purkinje cell layer structural organization  
    involved_in cerebellar Purkinje cell layer structural organization  
    involved_in cerebellar molecular layer formation  
    involved_in cerebellar molecular layer formation  
    involved_in cerebellar molecular layer formation  
    involved_in clathrin-dependent endocytosis PubMed 
    involved_in compartment pattern specification  
    acts_upstream_of_or_within compartment pattern specification  
    acts_upstream_of_or_within determination of left/right symmetry  
    involved_in developmental process  
    involved_in endothelial tip cell fate specification  
    involved_in endothelial tip cell fate specification  
    involved_in endothelial tip cell fate specification  
    involved_in energy homeostasis  
    involved_in energy homeostasis  
    involved_in energy homeostasis  
    involved_in heart looping  
    involved_in heart looping  
    involved_in inhibition of neuroepithelial cell differentiation  
    acts_upstream_of_or_within inhibition of neuroepithelial cell differentiation  
    involved_in inner ear auditory receptor cell differentiation  
    acts_upstream_of inner ear auditory receptor cell differentiation  
    acts_upstream_of_or_within inner ear development  
    involved_in lateral inhibition  
    involved_in lateral inhibition  
    involved_in lateral inhibition  
    involved_in left/right axis specification  
    involved_in left/right axis specification  
    involved_in loop of Henle development  
    involved_in loop of Henle development  
    involved_in marginal zone B cell differentiation  
    involved_in marginal zone B cell differentiation  
    involved_in marginal zone B cell differentiation  
    involved_in myeloid cell differentiation  
    acts_upstream_of myeloid cell differentiation  
    involved_in negative regulation of Notch signaling pathway  
    involved_in negative regulation of cardiac muscle cell differentiation  
    involved_in negative regulation of cardiac muscle cell differentiation  
    acts_upstream_of_or_within negative regulation of cell differentiation  
    involved_in negative regulation of cell differentiation  
    involved_in negative regulation of cell differentiation  
    involved_in negative regulation of cell population proliferation  
    involved_in negative regulation of cell population proliferation  
    involved_in negative regulation of cell population proliferation  
    involved_in negative regulation of epidermal cell differentiation  
    involved_in negative regulation of epidermal cell differentiation  
    involved_in negative regulation of epithelial cell differentiation  
    involved_in negative regulation of epithelial cell differentiation  
    involved_in negative regulation of glial cell apoptotic process  
    involved_in negative regulation of glial cell apoptotic process  
    involved_in negative regulation of glial cell apoptotic process  
    involved_in negative regulation of inner ear auditory receptor cell differentiation  
    acts_upstream_of_or_within negative regulation of inner ear auditory receptor cell differentiation  
    involved_in negative regulation of interleukin-10 production  
    involved_in negative regulation of interleukin-10 production  
    involved_in negative regulation of myeloid cell differentiation  
    acts_upstream_of_or_within negative regulation of myeloid cell differentiation  
    involved_in negative regulation of myoblast differentiation  
    involved_in negative regulation of myoblast differentiation  
    involved_in negative regulation of myoblast differentiation  
    acts_upstream_of_or_within negative regulation of neuron differentiation  
    involved_in negative regulation of neuron differentiation  
    involved_in negative regulation of neuron differentiation  
    involved_in nephron development  
    involved_in nephron development  
    involved_in nervous system development PubMed 
    involved_in neuroepithelial cell differentiation  
    acts_upstream_of neuroepithelial cell differentiation  
    acts_upstream_of neuron differentiation  
    involved_in neuron fate specification  
    involved_in neuron fate specification  
    involved_in neuron fate specification  
    involved_in neuronal stem cell population maintenance  
    involved_in neuronal stem cell population maintenance  
    involved_in neuronal stem cell population maintenance  
    involved_in organ growth  
    involved_in organ growth  
    involved_in organ growth  
    involved_in positive regulation of Notch signaling pathway PubMed 
    involved_in positive regulation of Notch signaling pathway  
    acts_upstream_of_or_within positive regulation of Notch signaling pathway  
    involved_in positive regulation of Notch signaling pathway  
    involved_in positive regulation of Notch signaling pathway  
    involved_in positive regulation of cell population proliferation  
    involved_in positive regulation of cell population proliferation  
    involved_in positive regulation of cell population proliferation  
    involved_in positive regulation of endocytosis  
    involved_in positive regulation of endocytosis  
    involved_in positive regulation of endocytosis  
    involved_in positive regulation of gene expression  
    acts_upstream_of positive regulation of gene expression  
    acts_upstream_of_or_within positive regulation of gene expression  
    involved_in positive regulation of skeletal muscle tissue growth  
    involved_in positive regulation of skeletal muscle tissue growth  
    involved_in positive regulation of skeletal muscle tissue growth  
    involved_in positive regulation of sprouting angiogenesis  
    involved_in positive regulation of sprouting angiogenesis  
    involved_in positive regulation of sprouting angiogenesis  
    involved_in positive regulation of transcription by RNA polymerase II  
    involved_in positive regulation of transcription by RNA polymerase II  
    involved_in proximal tubule development  
    involved_in proximal tubule development  
    involved_in proximal/distal pattern formation  
    involved_in proximal/distal pattern formation  
    involved_in proximal/distal pattern formation  
    involved_in regulation of blood pressure  
    involved_in regulation of blood pressure  
    involved_in regulation of blood pressure  
    involved_in regulation of cell adhesion  
    involved_in regulation of cell adhesion  
    involved_in regulation of cell division  
    involved_in regulation of cell division  
    involved_in regulation of cell division  
    involved_in regulation of growth  
    involved_in regulation of growth  
    involved_in regulation of neurogenesis  
    acts_upstream_of_or_within regulation of neurogenesis  
    involved_in regulation of neurogenesis  
    involved_in regulation of neurogenesis  
    involved_in regulation of skeletal muscle tissue growth  
    involved_in regulation of skeletal muscle tissue growth  
    involved_in regulation of somitogenesis  
    involved_in regulation of somitogenesis  
    involved_in regulation of somitogenesis  
    involved_in regulation of vascular endothelial growth factor receptor signaling pathway  
    involved_in regulation of vascular endothelial growth factor receptor signaling pathway  
    involved_in regulation of vascular endothelial growth factor signaling pathway  
    involved_in regulation of vascular endothelial growth factor signaling pathway  
    involved_in regulation of vascular endothelial growth factor signaling pathway  
    involved_in retina development in camera-type eye  
    involved_in retina development in camera-type eye  
    involved_in retina morphogenesis in camera-type eye  
    involved_in retina morphogenesis in camera-type eye  
    involved_in retina morphogenesis in camera-type eye  
    involved_in skeletal muscle tissue growth  
    involved_in skeletal muscle tissue growth  
    involved_in skeletal muscle tissue growth  
    involved_in skin epidermis development  
    involved_in skin epidermis development  
    involved_in skin epidermis development  
    involved_in somite specification  
    acts_upstream_of_or_within somite specification  
    acts_upstream_of_or_within somitogenesis  
    involved_in somitogenesis  
    involved_in somitogenesis  
    involved_in spinal cord development  
    involved_in spinal cord development  
    involved_in spinal cord development  
    involved_in type B pancreatic cell development  
    involved_in type B pancreatic cell development  
    involved_in type B pancreatic cell development  
    Items 1 - 25 of 166
    Component Evidence Code Pubs
    located_in adherens junction  
    located_in adherens junction  
    located_in adherens junction  
    located_in apical plasma membrane  
    located_in apical plasma membrane  
    located_in apical plasma membrane  
    located_in cytoplasmic vesicle  
    located_in cytoplasmic vesicle  
    located_in membrane  
    located_in membrane raft  
    located_in membrane raft  
    located_in membrane raft  
    is_active_in plasma membrane  
    located_in plasma membrane  
    located_in plasma membrane  

    General protein information

    Preferred Names
    delta-like protein 1
    Names
    delta1
    drosophila Delta homolog 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_032063.3NP_114452.2  delta-like protein 1 precursor

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/Swiss-Prot
      P97677
      UniProtKB/TrEMBL
      A6KB40, G3V7W6
      Related
      ENSRNOP00000073159.1, ENSRNOT00000080429.3
      Conserved Domains (4) summary
      smart00051
      Location:158220
      DSL; delta serrate ligand
      cd00054
      Location:442477
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      pfam00008
      Location:484514
      EGF; EGF-like domain
      pfam07657
      Location:2291
      MNNL; N-terminus of Notch ligand

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      64985161..64993274 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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