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    Gpc3 glypican 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25236, updated on 9-Dec-2024

    Summary

    Official Symbol
    Gpc3provided by RGD
    Official Full Name
    glypican 3provided by RGD
    Primary source
    RGD:2725
    See related
    EnsemblRapid:ENSRNOG00000060179 AllianceGenome:RGD:2725
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    OCI-5
    Summary
    Predicted to enable peptidyl-dipeptidase inhibitor activity. Acts upstream of or within negative regulation of canonical Wnt signaling pathway and positive regulation of Wnt signaling pathway, planar cell polarity pathway. Located in plasma membrane. Used to study hepatocellular carcinoma. Human ortholog(s) of this gene implicated in Simpson-Golabi-Behmel syndrome type 1 and nephroblastoma. Orthologous to human GPC3 (glypican 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 1010.0), Kidney (RPKM 338.9) and 5 other tissues See more
    Orthologs
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    Genomic context

    See Gpc3 in Genome Data Viewer
    Location:
    Xq36
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (136789770..137157598, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (131868986..132236824, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (139579268..139947093, complement)

    Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein L7, pseudogene 10 Neighboring gene high mobility group protein B4-like Neighboring gene uncharacterized LOC134484170 Neighboring gene uncharacterized LOC120099376 Neighboring gene U6 spliceosomal RNA Neighboring gene microRNA 92a-2 Neighboring gene microRNA 363

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    General gene information

    Clone Names

    • MGC93606

    Gene Ontology Provided by RGD

    Items 1 - 25 of 76
    Process Evidence Code Pubs
    involved_in Wnt signaling pathway, planar cell polarity pathway  
    acts_upstream_of Wnt signaling pathway, planar cell polarity pathway  
    acts_upstream_of_or_within animal organ morphogenesis  
    involved_in anterior/posterior axis specification  
    acts_upstream_of_or_within anterior/posterior axis specification  
    involved_in biological_process  
    involved_in body morphogenesis  
    acts_upstream_of_or_within body morphogenesis  
    involved_in bone mineralization  
    acts_upstream_of_or_within bone mineralization  
    involved_in branching involved in ureteric bud morphogenesis  
    acts_upstream_of_or_within branching involved in ureteric bud morphogenesis  
    involved_in canonical Wnt signaling pathway  
    acts_upstream_of canonical Wnt signaling pathway  
    involved_in cell migration  
    involved_in cell migration involved in gastrulation  
    acts_upstream_of_or_within cell proliferation involved in kidney development  
    involved_in cell proliferation involved in kidney development  
    involved_in cell proliferation involved in metanephros development  
    acts_upstream_of_or_within cell proliferation involved in metanephros development  
    involved_in coronary vasculature development  
    acts_upstream_of_or_within coronary vasculature development  
    involved_in coronary vasculature development  
    involved_in embryonic hindlimb morphogenesis  
    acts_upstream_of_or_within embryonic hindlimb morphogenesis  
    involved_in epithelial cell proliferation  
    acts_upstream_of epithelial cell proliferation  
    acts_upstream_of_or_within epithelial cell proliferation  
    acts_upstream_of_or_within kidney development  
    involved_in lung development  
    acts_upstream_of_or_within lung development  
    involved_in mesenchymal cell proliferation involved in ureteric bud development  
    involved_in mesenchymal cell proliferation involved in ureteric bud development  
    involved_in mesonephric duct morphogenesis  
    acts_upstream_of_or_within mesonephric duct morphogenesis  
    involved_in mesonephric duct morphogenesis  
    acts_upstream_of_or_within negative regulation of canonical Wnt signaling pathway PubMed 
    involved_in negative regulation of canonical Wnt signaling pathway  
    acts_upstream_of_or_within negative regulation of canonical Wnt signaling pathway  
    acts_upstream_of_or_within negative regulation of cell population proliferation  
    involved_in negative regulation of epithelial cell proliferation  
    acts_upstream_of_or_within negative regulation of epithelial cell proliferation  
    involved_in negative regulation of growth  
    acts_upstream_of_or_within negative regulation of growth  
    involved_in negative regulation of smoothened signaling pathway  
    acts_upstream_of_or_within negative regulation of smoothened signaling pathway  
    involved_in negative regulation of smoothened signaling pathway  
    involved_in osteoclast differentiation  
    acts_upstream_of_or_within osteoclast differentiation  
    involved_in positive regulation of BMP signaling pathway  
    acts_upstream_of_or_within positive regulation of BMP signaling pathway  
    involved_in positive regulation of D-glucose import  
    acts_upstream_of_or_within positive regulation of D-glucose import  
    acts_upstream_of_or_within positive regulation of Wnt signaling pathway, planar cell polarity pathway PubMed 
    involved_in positive regulation of Wnt signaling pathway, planar cell polarity pathway  
    acts_upstream_of_or_within positive regulation of Wnt signaling pathway, planar cell polarity pathway PubMed 
    acts_upstream_of_or_within positive regulation of Wnt signaling pathway, planar cell polarity pathway  
    involved_in positive regulation of canonical Wnt signaling pathway  
    involved_in positive regulation of canonical Wnt signaling pathway  
    involved_in positive regulation of canonical Wnt signaling pathway  
    involved_in positive regulation of endocytosis  
    acts_upstream_of_or_within positive regulation of endocytosis  
    involved_in positive regulation of endocytosis  
    involved_in positive regulation of protein catabolic process  
    acts_upstream_of_or_within positive regulation of protein catabolic process  
    involved_in positive regulation of protein catabolic process  
    involved_in positive regulation of smoothened signaling pathway  
    acts_upstream_of_or_within positive regulation of smoothened signaling pathway  
    involved_in regulation of canonical Wnt signaling pathway  
    acts_upstream_of_or_within regulation of growth  
    involved_in regulation of non-canonical Wnt signaling pathway  
    involved_in regulation of protein localization to membrane  
    involved_in response to bacterium  
    acts_upstream_of_or_within response to bacterium  
    involved_in smoothened signaling pathway  
    acts_upstream_of smoothened signaling pathway  
    Items 1 - 25 of 76
    Component Evidence Code Pubs
    is_active_in cell surface  
    located_in collagen-containing extracellular matrix  
    located_in lysosome  
    located_in lysosome  
    is_active_in plasma membrane  
    located_in plasma membrane PubMed 
    located_in plasma membrane  
    located_in plasma membrane  
    located_in side of membrane  

    General protein information

    Preferred Names
    glypican-3
    Names
    defective in Simpson-Golabi-Behmel overgrowth syndrome
    intestinal protein OCI-5
    proteoglycan GPC3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012774.2NP_036906.2  glypican-3 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021
      UniProtKB/Swiss-Prot
      P13265, Q5U326
      UniProtKB/TrEMBL
      A0A0G2KBA2, A6JMU0
      Related
      ENSRNOP00000075712.2, ENSRNOT00000090442.3
      Conserved Domains (1) summary
      pfam01153
      Location:14576
      Glypican

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086039.1 Reference GRCr8

      Range
      136789770..137157598 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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