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    Tnrc6a trinucleotide repeat containing adaptor 6A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 308971, updated on 9-Dec-2024

    Summary

    Official Symbol
    Tnrc6aprovided by RGD
    Official Full Name
    trinucleotide repeat containing adaptor 6Aprovided by RGD
    Primary source
    RGD:1307268
    See related
    EnsemblRapid:ENSRNOG00000024737 AllianceGenome:RGD:1307268
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Tnrc6
    Summary
    Predicted to enable RNA binding activity. Predicted to be involved in P-body assembly; miRNA-mediated gene silencing by inhibition of translation; and positive regulation of nuclear-transcribed mRNA poly(A) tail shortening. Predicted to act upstream of or within cellular response to starvation and endoderm development. Predicted to be located in Golgi apparatus. Predicted to be part of RISC complex. Predicted to be active in P-body and nucleoplasm. Human ortholog(s) of this gene implicated in familial adult myoclonic epilepsy 6. Orthologous to human TNRC6A (trinucleotide repeat containing adaptor 6A). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 150.0), Lung (RPKM 137.5) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Tnrc6a in Genome Data Viewer
    Location:
    1q36
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (186992457..187146764)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (177561898..177715669)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (192991584..193146403)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134485175 Neighboring gene RB binding protein 6, ubiquitin ligase Neighboring gene uncharacterized LOC120099930 Neighboring gene RNA, U6 small nuclear 799 Neighboring gene uncharacterized LOC134483807 Neighboring gene solute carrier family 5 member 11

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA binding  
    Component Evidence Code Pubs
    located_in Golgi apparatus  
    located_in Golgi apparatus  
    is_active_in P-body  
    is_active_in P-body  
    located_in P-body  
    part_of RISC complex  
    located_in cytosol  
    located_in cytosol  
    located_in intracellular membrane-bounded organelle  
    located_in membrane  
    is_active_in nucleoplasm  
    located_in nucleoplasm  

    General protein information

    Preferred Names
    trinucleotide repeat-containing gene 6A protein
    Names
    trinucleotide repeat containing 6
    trinucleotide repeat containing 6a

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001395157.2NP_001382086.1  trinucleotide repeat-containing gene 6A protein

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A0A8I6GAR2, F1M9Y8
      Related
      ENSRNOP00000083407.1, ENSRNOT00000096111.2
      Conserved Domains (5) summary
      pfam10427
      Location:10781203
      Ago_hook; Argonaute hook
      pfam12938
      Location:12981483
      M_domain; M domain of GW182
      pfam16608
      Location:15081769
      TNRC6-PABC_bdg; TNRC6-PABC binding domain
      cd12711
      Location:17771868
      RRM_TNRC6A; RNA recognition motif (RRM) found in vertebrate GW182 autoantigen
      NF033849
      Location:604863
      ser_rich_anae_1; serine-rich protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      186992457..187146764
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008759747.4XP_008757969.1  trinucleotide repeat-containing gene 6A protein isoform X1

      UniProtKB/TrEMBL
      F1M9Y8
      Conserved Domains (4) summary
      cd12711
      Location:17911873
      RRM_TNRC6A; RNA recognition motif in vertebrate GW182 autoantigen
      pfam10427
      Location:10811212
      Ago_hook; Argonaute hook
      pfam12938
      Location:13071492
      M_domain; M domain of GW182
      pfam16608
      Location:15151790
      TNRC6-PABC_bdg; TNRC6-PABC binding domain
    2. XM_017589208.3XP_017444697.1  trinucleotide repeat-containing gene 6A protein isoform X3

      UniProtKB/TrEMBL
      F1M9Y8
    3. XM_017589209.3XP_017444698.1  trinucleotide repeat-containing gene 6A protein isoform X6

      UniProtKB/TrEMBL
      A0A8I6ASC0
      Related
      ENSRNOP00000107027.1, ENSRNOT00000145881.1
      Conserved Domains (4) summary
      cd12711
      Location:17421824
      RRM_TNRC6A; RNA recognition motif in vertebrate GW182 autoantigen
      pfam10427
      Location:10811212
      Ago_hook; Argonaute hook
      pfam12938
      Location:12921443
      M_domain; M domain of GW182
      pfam16608
      Location:14661741
      TNRC6-PABC_bdg; TNRC6-PABC binding domain
    4. XM_063263201.1XP_063119271.1  trinucleotide repeat-containing gene 6A protein isoform X9

      UniProtKB/TrEMBL
      A0A8I6ASC0
    5. XM_008759749.4XP_008757971.1  trinucleotide repeat-containing gene 6A protein isoform X2

      UniProtKB/TrEMBL
      F1M9Y8
      Conserved Domains (4) summary
      cd12711
      Location:17801862
      RRM_TNRC6A; RNA recognition motif in vertebrate GW182 autoantigen
      pfam10427
      Location:10811201
      Ago_hook; Argonaute hook
      pfam12938
      Location:12961481
      M_domain; M domain of GW182
      pfam16608
      Location:15041779
      TNRC6-PABC_bdg; TNRC6-PABC binding domain
    6. XM_039078265.2XP_038934193.1  trinucleotide repeat-containing gene 6A protein isoform X7

      UniProtKB/TrEMBL
      F1M9Y8
      Conserved Domains (5) summary
      pfam10427
      Location:10341159
      Ago_hook; Argonaute hook
      pfam12938
      Location:12541439
      M_domain; M domain of GW182
      pfam16608
      Location:14641725
      TNRC6-PABC_bdg; TNRC6-PABC binding domain
      cd12711
      Location:17331824
      RRM_TNRC6A; RNA recognition motif (RRM) found in vertebrate GW182 autoantigen
      NF033849
      Location:560819
      ser_rich_anae_1; serine-rich protein
    7. XM_063263199.1XP_063119269.1  trinucleotide repeat-containing gene 6A protein isoform X8

      UniProtKB/TrEMBL
      A0A8I6ASC0
    8. XM_063263213.1XP_063119283.1  trinucleotide repeat-containing gene 6A protein isoform X10

      UniProtKB/TrEMBL
      F1M9Y8
    9. XM_063263192.1XP_063119262.1  trinucleotide repeat-containing gene 6A protein isoform X4

      UniProtKB/TrEMBL
      F1M9Y8
    10. XM_063263204.1XP_063119274.1  trinucleotide repeat-containing gene 6A protein isoform X10

      UniProtKB/TrEMBL
      F1M9Y8
    11. XM_063263194.1XP_063119264.1  trinucleotide repeat-containing gene 6A protein isoform X5

      UniProtKB/TrEMBL
      A6I8Z0
    12. XM_063263221.1XP_063119291.1  trinucleotide repeat-containing gene 6A protein isoform X10

      UniProtKB/TrEMBL
      F1M9Y8

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