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    Ccl6 C-C motif chemokine ligand 6 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 287910, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ccl6provided by RGD
    Official Full Name
    C-C motif chemokine ligand 6provided by RGD
    Primary source
    RGD:1303200
    See related
    EnsemblRapid:ENSRNOG00000030021 AllianceGenome:RGD:1303200
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Mrp-1; Scay6
    Summary
    Enables chemokine activity. Involved in cell chemotaxis. Predicted to be active in extracellular space. Orthologous to several human genes including CCL23 (C-C motif chemokine ligand 23). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 2027.6), Liver (RPKM 970.2) and 6 other tissues See more
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    Genomic context

    See Ccl6 in Genome Data Viewer
    Location:
    10q26
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (68877692..68883366, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (68380185..68385859, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (70798118..70802750, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103693406 Neighboring gene C-C motif chemokine ligand 9 Neighboring gene ribosomal protein L30, pseudogene 12 Neighboring gene C-C motif chemokine ligand 3 Neighboring gene C-C motif chemokine ligand 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables CCR chemokine receptor binding  
    enables chemokine activity  
    enables chemokine activity PubMed 
    enables chemokine activity  
    Process Evidence Code Pubs
    involved_in antimicrobial humoral immune response mediated by antimicrobial peptide  
    involved_in cell chemotaxis  
    involved_in cell chemotaxis PubMed 
    involved_in cell chemotaxis  
    involved_in chemokine-mediated signaling pathway  
    involved_in immune response  
    involved_in inflammatory response  
    involved_in osteoclast differentiation PubMed 
    involved_in positive regulation of cell migration  
    involved_in signal transduction  
    Component Evidence Code Pubs
    is_active_in extracellular space  
    located_in extracellular space  

    General protein information

    Preferred Names
    C-C motif chemokine 6
    Names
    chemokine (C-C motif) ligand 6
    chemokine ligand 6
    small-inducible cytokine A6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001004202.3NP_001004202.1  C-C motif chemokine 6 precursor

      See identical proteins and their annotated locations for NP_001004202.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/Swiss-Prot
      A1EC85, Q68FP3, Q6IVB4
      UniProtKB/TrEMBL
      A6HHI5
      Related
      ENSRNOP00000105793.1, ENSRNOT00000146149.1
      Conserved Domains (1) summary
      cd00272
      Location:49104
      Chemokine_CC; 1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteine residues; includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; some members (e.g. 2HCC) contain an ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      68877692..68883366 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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