U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Gkn2 gastrokine 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 297419, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Gkn2provided by RGD
    Official Full Name
    gastrokine 2provided by RGD
    Primary source
    RGD:1311934
    See related
    EnsemblRapid:ENSRNOG00000009256 AllianceGenome:RGD:1311934
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1311934
    Summary
    Predicted to be involved in regulation of cell population proliferation. Predicted to act upstream of or within response to bacterium. Predicted to be located in basal part of cell. Predicted to be active in extracellular space. Orthologous to human GKN2 (gastrokine 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 3.1), Brain (RPKM 1.9) and 9 other tissues See more
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Gkn2 in Genome Data Viewer
    Location:
    4q34
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (121335642..121381680)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (119778326..119824366)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (119131255..119177329)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene glutamine fructose-6-phosphate transaminase 1 Neighboring gene ANTXR cell adhesion molecule 1 Neighboring gene uncharacterized LOC120102329 Neighboring gene gastrokine 1 Neighboring gene gastrokine 3 Neighboring gene bone morphogenetic protein 10

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Identification of blottin: a novel gastric trefoil factor family-2 binding protein. Otto WR, et al. Proteomics, 2006 Aug. PMID 16888721
    2. Gastrokine-2 is transiently expressed in the endodermal and endothelial cells of the maturing mouse yolk sac. Antas VI, et al. Gene Expr Patterns, 2014 Nov. PMID 25290738
    3. Impact of lactobacilli on orally acquired listeriosis. Archambaud C, et al. Proc Natl Acad Sci U S A, 2012 Oct 9. PMID 23012479, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in regulation of cell population proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within response to bacterium ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in basal part of cell ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    gastrokine-2
    Names
    blottin

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039686.2 → NP_001034775.1  gastrokine-2 precursor

      See identical proteins and their annotated locations for NP_001034775.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/Swiss-Prot
      Q29TV8
      UniProtKB/TrEMBL
      A6IB04
      Related
      ENSRNOP00000063736.1, ENSRNOT00000067651.4
      Conserved Domains (1) summary
      smart01039
      Location:54 → 149
      BRICHOS; The BRICHOS domain is found in a variety of proteins implicated in dementia, respiratory distress and cancer

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      121335642..121381680
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039107366.1 → XP_038963294.1  gastrokine-2 isoform X2

      UniProtKB/Swiss-Prot
      Q29TV8
      UniProtKB/TrEMBL
      A6IB04
      Conserved Domains (1) summary
      smart01039
      Location:54 → 149
      BRICHOS; The BRICHOS domain is found in a variety of proteins implicated in dementia, respiratory distress and cancer

    2. XM_039107365.2 → XP_038963293.1  gastrokine-2 isoform X1

      Conserved Domains (1) summary
      smart01039
      Location:63 → 158
      BRICHOS; The BRICHOS domain is found in a variety of proteins implicated in dementia, respiratory distress and cancer
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q29TV8.1 GenPept UniProtKB/Swiss-Prot:Q29TV8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools