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    Lsm10 LSM10, U7 small nuclear RNA associated [ Rattus norvegicus (Norway rat) ]

    Gene ID: 366468, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Lsm10provided by RGD
    Official Full Name
    LSM10, U7 small nuclear RNA associatedprovided by RGD
    Primary source
    RGD:1584914
    See related
    EnsemblRapid:ENSRNOG00000026978 AllianceGenome:RGD:1584914
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable U7 snRNA binding activity and histone pre-mRNA DCP binding activity. Predicted to be involved in mRNA 3'-end processing by stem-loop binding activity and cleavage and positive regulation of G1/S transition of mitotic cell cycle. Predicted to be located in Cajal body. Predicted to be part of U7 snRNP and cytoplasmic U snRNP body. Predicted to be active in nuclear body. Orthologous to human LSM10 (LSM10, U7 small nuclear RNA associated). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 45.1), Adrenal (RPKM 35.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Lsm10 in Genome Data Viewer
    Location:
    5q36
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (143649817..143660391)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (138365983..138375856)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (144106339..144108703)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene mitochondrial ribosomal protein S15 Neighboring gene organic solute carrier partner 1 Neighboring gene ribosomal protein S14, pseudogene 7 Neighboring gene serine/threonine kinase 40 Neighboring gene uncharacterized LOC108351032

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. ZFP100, a component of the active U7 snRNP limiting for histone pre-mRNA processing, is required for entry into S phase. Wagner EJ, et al. Mol Cell Biol, 2006 Sep. PMID 16914750, Free PMC Article
    2. Purified U7 snRNPs lack the Sm proteins D1 and D2 but contain Lsm10, a new 14 kDa Sm D1-like protein. Pillai RS, et al. EMBO J, 2001 Oct 1. PMID 11574479, Free PMC Article
    3. Three proteins of the U7-specific Sm ring function as the molecular ruler to determine the site of 3'-end processing in mammalian histone pre-mRNA. Yang XC, et al. Mol Cell Biol, 2009 Aug. PMID 19470752, Free PMC Article
    4. Purification of human telomerase complexes identifies factors involved in telomerase biogenesis and telomere length regulation. Fu D, et al. Mol Cell, 2007 Dec 14. PMID 18082603, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables U7 snRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables U7 snRNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables histone pre-mRNA DCP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone pre-mRNA DCP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in mRNA 3'-end processing by stem-loop binding and cleavage IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of G1/S transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Cajal body ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of U7 snRNP ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of cytoplasmic U snRNP body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nuclear body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    U7 snRNA-associated Sm-like protein LSm10
    Names
    U7 snRNP-specific Sm-like protein LSM10

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108976.1 → NP_001102446.1  U7 snRNA-associated Sm-like protein LSm10

      See identical proteins and their annotated locations for NP_001102446.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473968
      UniProtKB/TrEMBL
      A6IS89, A6IS90, B2RYU1
      Related
      ENSRNOP00000106481.1, ENSRNOT00000162109.1
      Conserved Domains (1) summary
      cd01733
      Location:8 → 85
      LSm10; Like-Sm protein 10

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      143649817..143660391
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006238897.4 → XP_006238959.1  U7 snRNA-associated Sm-like protein LSm10 isoform X1

      See identical proteins and their annotated locations for XP_006238959.1

      UniProtKB/TrEMBL
      A6IS89, A6IS90, B2RYU1
      Conserved Domains (1) summary
      cd01733
      Location:8 → 85
      LSm10; Like-Sm protein 10

    2. XM_017593541.3 → XP_017449030.1  U7 snRNA-associated Sm-like protein LSm10 isoform X1

      UniProtKB/TrEMBL
      A6IS89, A6IS90, B2RYU1
      Conserved Domains (1) summary
      cd01733
      Location:8 → 85
      LSm10; Like-Sm protein 10

    3. XM_006238895.5 → XP_006238957.1  U7 snRNA-associated Sm-like protein LSm10 isoform X1

      See identical proteins and their annotated locations for XP_006238957.1

      UniProtKB/TrEMBL
      A6IS89, A6IS90, B2RYU1
      Conserved Domains (1) summary
      cd01733
      Location:8 → 85
      LSm10; Like-Sm protein 10

    4. XM_063288119.1 → XP_063144189.1  U7 snRNA-associated Sm-like protein LSm10 isoform X1

      UniProtKB/TrEMBL
      A6IS89, A6IS90, B2RYU1
    Nucleotide Protein Strain
    Heading Accession and Version

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