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    Nfatc2ip nuclear factor of activated T-cells 2 interacting protein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 308983, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Nfatc2ipprovided by RGD
    Official Full Name
    nuclear factor of activated T-cells 2 interacting proteinprovided by RGD
    Primary source
    RGD:1359096
    See related
    EnsemblRapid:ENSRNOG00000057384 AllianceGenome:RGD:1359096
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to be located in cytoplasm and nucleus. Orthologous to human NFATC2IP (nuclear factor of activated T cells 2 interacting protein). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 114.5), Thymus (RPKM 65.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Nfatc2ip in Genome Data Viewer
    Location:
    1q36
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (190385416..190403309, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (180954834..180971847, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (197785966..197800943, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene linker for activation of T cells Neighboring gene SPNS lysolipid transporter 1, lysophospholipid Neighboring gene ribosomal protein L36 like 3 Neighboring gene CD19 molecule

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. miR-31-5p suppresses myocardial hypertrophy by targeting Nfatc2ip. Zhao L, et al. J Cell Mol Med, 2024 Jun. PMID 38894694, Free PMC Article
    2. NF-AT-Driven interleukin-4 transcription potentiated by NIP45. Hodge MR, et al. Science, 1996 Dec 13. PMID 8943202
    3. Sequential involvement of NFAT and Egr transcription factors in FasL regulation. Rengarajan J, et al. Immunity, 2000 Mar. PMID 10755616
    4. Foxp3 interacts with nuclear factor of activated T cells and NF-kappa B to repress cytokine gene expression and effector functions of T helper cells. Bettelli E, et al. Proc Natl Acad Sci U S A, 2005 Apr 5. PMID 15790681, Free PMC Article
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. miR-31-5p suppresses myocardial hypertrophy by targeting Nfatc2ip.
      Title: miR-31-5p suppresses myocardial hypertrophy by targeting Nfatc2ip.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC93987

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    NFATC2-interacting protein
    Names
    nuclear factor of activated T-cells, cytoplasmic 2-interacting protein
    nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 interacting protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001007692.1 → NP_001007693.1  NFATC2-interacting protein

      See identical proteins and their annotated locations for NP_001007693.1

      Status: PROVISIONAL

      Source sequence(s)
      BC079050
      UniProtKB/Swiss-Prot
      Q6AYG7
      UniProtKB/TrEMBL
      A6I949
      Related
      ENSRNOP00000111459.1, ENSRNOT00000121352.1
      Conserved Domains (2) summary
      smart00213
      Location:260 → 329
      UBQ; Ubiquitin homologues
      cl00155
      Location:343 → 412
      UBQ; Ubiquitin-like proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      190385416..190403309 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039078300.2 → XP_038934228.1  NFATC2-interacting protein isoform X1

      Conserved Domains (2) summary
      cd17078
      Location:75 → 147
      Ubl_SLD1_NFATC2ip; SUMO-like domain 1 (SLD1), structurally similar to a beta-grasp ubiquitin-like fold, found in nuclear factor of activated T-cells 2 interacting protein (NFATC2ip) and similar proteins
      cd17079
      Location:158 → 230
      Ubl_SLD2_NFATC2ip; SUMO-like domain 2 (SLD2), structurally similar to a beta-grasp ubiquitin-like fold, found in nuclear factor of activated T-cells 2 interacting protein (NFATC2ip) and similar proteins

    2. XM_063263249.1 → XP_063119319.1  NFATC2-interacting protein isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6AYG7.1 GenPept UniProtKB/Swiss-Prot:Q6AYG7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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